人类干细胞之伦理原则与监管政策（上）

本文分两大部分。第一部分从干细胞的功能、来源与社会争议性3种角度划分了人类干细胞的种类,并讨论与人类干细胞研究及临床应用相关的9条伦理原则,特别强调了西方国家对胚胎捐赠在知情同意方面的伦理耍求。第二部分讨论了制定监管人类干细胞研究的3个原则,并简单地介绍了在英美各国监管的情况,其中较详细地评论了英国的种种立法过程、设立的法定机构和执行的种种政策与机制,作为在我国讨论类似政策参考之用。     

生殖性复制与医疗性复制之伦理区分

目前,各国政府和学术界对生殖性复制持否定态度是一致的,但对医疗性复制却存在激烈的争论。争论主要涉及人类胚胎的来源、胚胎的地位,以及胚胎干细胞成果应用的可接受性。     

Paths to Late Midlife Well-Being for Women and Men: The Importance of Identity Development and Social Role Quality

Theories of adult development suggest that personality development and social role involvements are sources of adult well-being for both men and women. However, previous research on this topic has focused mainly on (a) women, and (b) early stages of adulthood. We tested an alternative model for predicting late-midlife adults’ well-being, with role quality, number of roles, and healthy adaptation to late midlife (reflected in lower concern about aging) as mediators of the relationship between young adult identity development and well-being in late midlife. Results indicated that the model fit women’s experience very well, and men’s experience somewhat. Follow-up analyses indicated that the model fit men’s experience with respect to family role quality, but that young adult identity played a lesser role in men’s well-being in later midlife, and that problems in the late-midlife work role were reflected in concerns about aging for men, but not for women.     

Generalized Anxiety Disorder in Hispanics: Symptom Characteristics and Prediction of Severity

Literature suggests that an increasing number of Hispanic people suffer with GAD, and possible associated problems include high costs for treatment and elevated risk of severe impairment. The current study examined components of anxiety, as measured by currently available assessment instruments in both English and Spanish languages, among bilingual Hispanic individuals with GAD. Participants completed all instruments in both languages. Relations between these self-report measures and clinician-rated GAD severity were also studied. In factor analyses, the Spanish measures yielded two factors, the first of which included all instruments assessing physiological components of anxiety and one content specific measure of worry. The second factor included one worry scale and one trait anxiety scale. The English measures yielded a single factor solution. Regression analyses revealed that for the English measures, the BAI and PSWQ were statistically significant predictors of GAD severity. For the Spanish measures, the BAI was the only statistically significant predictor.     

父母成人依恋、怜悯与亲子关系质量:主客体互倚分析

本研究考察了父母的成人依恋对亲子关系的影响以及怜悯的中介作用。采用方便取样法调查广东省某市小学2~5年级学生的父母。534对父母自我报告了各自的成人依恋、怜悯和亲子关系质量。主客体互倚模型分析发现：（1）父母各自的依恋焦虑和依恋回避显著负向预测自己与孩子的关系质量（主体效应）,但无法显著预测伴侣与孩子的关系质量（客体效应）;（2）父母各自的怜悯在上述主体效应中起到中介作用;（3）母亲的怜悯在自身依恋回避对父子关系的客体效应中起到“遮掩效应”;（4）母亲的怜悯在自身依恋焦虑对父子关系的客体效应中起到中介作用。研究结果有利于从成对关系视角理解父母成人依恋如何影响亲子关系,实际干预中可以通过提高父母的怜悯能力来改善亲子关系。     

Conception of Adulthood Among Iranian Emerging Adults

Using a questionnaire adapted from Arnett and Padilla‐Walker (2015), the authors examined the concept of adulthood among 366 Iranian emerging adults ages 17 to 29. Results suggested that the concept and criteria of adulthood are influenced by the cultural context. Implications for practice and recommendations for future research are discussed.     

Mothers' representations of caregiving and their adult children's representations of attachment: intergenerational concordance and relations to beliefs about mothering

Mothers (N= 35) and their adult children completed questionnaires and were interviewed in order to examine relationships between mothers' caregiving representations and their adult children's attachment representations, and relationships between attachment/caregiving representations and beliefs about mothering. Mothers' and their children's accounts of and present thinking about their past relationship were highly similar, indicating that the two parts develop concordant states of mind regarding their relationship. In contrast, there was no relationship between mothers' and their adult children's beliefs about mothering, suggesting that such beliefs are not simply passed on from generation to generation within families. Attachment/caregiving classification interacted with generation in influencing a belief that biological facts determine maternal behavior, young adults with preoccupied attachment being particularly prone to reject this idea. Attachment/caregiving classification also had a significant effect on participants' tendency to adhere to an idealized conception of mothering, this tendency being associated with a dismissive attachment/caregiving representation.     

骨髓造血干细胞移植治疗自身免疫性疾病的进展

自身免疫疾病发病机制复杂,目前尚缺少有效的治疗方法。近年来发现造血干细胞移植可以通过免疫重建显著缓解甚至治愈自身免疫病。笔者对近年来造血干细胞移植治疗自身免疫病进行了介绍和综述,就其在1型糖尿病这一领域的研究进展进行了述评,探讨造血干细胞移植用于治疗自身免疫病的前景和待解决的问题。     

子宫内膜干细胞与子宫内膜异位症的治疗

子宫内膜异位症（EMs）是妇科最常见的疾病之一,引起痛经、月经不调、不孕等,严重危害妇女的身心健康,影响患者生活质量。其发病率逐年升高,发病机制不清,疗效差,一直是困扰妇科医生的难题之一。最近提出的子宫内膜干细胞（SC）学说认为EMs起源于SC,EMs病灶的维持和发展是子宫内膜SC不断更新和分化的结果。因此,治疗的关键应是针对子宫内膜SC,通过靶向子宫内膜SC及其异常调节的信号转导通路来治疗EMs。这对传统的治疗方式提出了巨大的挑战,也为有效的根治EMs开辟了新的思路。     

辩证看待干细胞移植的热化问题

现代科学技术的发展已经并正在给人类展现一个相互矛盾的事实：一方面是科学技术推动人类社会的巨大进步,促进社会生活的极大提高。如核能的利用、转基因作物、转基因治疗、动物克隆、干细胞的开发与应用等等,无不让人类充分地享受到现代科技带来的种种利益和好处。另外一方面人类的生存危机前所未有的加深,环境的恶化、水资源的污染、新的疾病和变异的菌种诞生等等。怎样运用哲学的理性的思维和方法来评判现代科技对人类的影响,摆脱其发展对社会所造成的两难困境,是一个必须解决的难题。以干细胞移植研究为例,如何辩证看待干细胞移植热化问题,如何运用哲学思维来看待干细胞移植的有利性和危害性,探究科学技术的可持续发展道路。