Sleep quality in healthy and mood-disordered persons predicts daily life emotional reactivity

Disordered sleep has been linked to impaired emotional functioning in healthy and depressed individuals. Little is known, however, about how chronic sleep problems influence emotional reactivity in everyday life. Participants with major or minor unipolar depressive disorder (n?=?60) and healthy controls (n?=?35) reported on sleep and emotional responses to daily life events using a computerised Experience Sampling Method. We examined whether impaired sleep quality influenced emotional reactivity to daily events, and if this relationship was altered by unipolar mood disorders. Among healthy individuals, sleep difficulties were associated with enhanced negative affect (NA) to unpleasant events and a dulled response to neutral events. However, among mood-disordered persons, sleep difficulties were associated with higher NA across all types of everyday life events. Impaired sleep quality differentially affects daily life emotional reactions as a function of depression.     

Comparing different kinds of words and word-word relations to test an habituation model of priming

Huber and O'Reilly (2003) proposed that neural habituation exists to solve a temporal parsing problem, minimizing blending between one word and the next when words are visually presented in rapid succession. They developed a neural dynamics habituation model, explaining the finding that short duration primes produce positive priming whereas long duration primes produce negative repetition priming. The model contains three layers of processing, including a visual input layer, an orthographic layer, and a lexical-semantic layer. The predicted effect of prime duration depends both on this assumed representational hierarchy and the assumption that synaptic depression underlies habituation. The current study tested these assumptions by comparing different kinds of words (e.g., words versus non-words) and different kinds of word-word relations (e.g., associative versus repetition). For each experiment, the predictions of the original model were compared to an alternative model with different representational assumptions. Experiment 1 confirmed the prediction that non-words and inverted words require longer prime durations to eliminate positive repetition priming (i.e., a slower transition from positive to negative priming). Experiment 2 confirmed the prediction that associative priming increases and then decreases with increasing prime duration, but remains positive even with long duration primes. Experiment 3 replicated the effects of repetition and associative priming using a within-subjects design and combined these effects by examining target words that were expected to repeat (e.g., viewing the target word ‘BACK' after the prime phrase ‘back to'). These results support the originally assumed representational hierarchy and more generally the role of habituation in temporal parsing and priming.     

Frontal EEG alpha band asymmetry as a predictor of reasoning deficiency in depressed people

Cognitive deficits in depression are mostly apparent in executive functions, especially when integration of information and reasoning is required. In parallel, there are also numerous studies pointing to the frontal alpha band asymmetry as a psychophysiological marker of depression. In this study, we explored the role of frontal alpha asymmetry as a potential factor explaining the cognitive problems accompanying depression. Twenty-six depressed and 26 control participants completed a reasoning task and underwent 5 minutes of electroencephalography recording. In line with the previous studies, depressed people showed difficulties with reasoning but we did not observe the relationship between frontal asymmetry in the alpha band and depression. However, we found that in the depressed group the frontal alpha asymmetry index was characterised by larger variance than in the control group, and it was also a strong predictor of cognitive functioning exclusively in the depressed group. Our results point to the disruption of a psychophysiological balance, reflected in changed frontal alpha asymmetry (into more left-sided frontal asymmetry in the alpha band, reflecting more right-sided cortical activity) as a possible brain correlate of cognitive disturbances present in depressive disorders.     

DRD2基因TaqIA多态性与同伴侵害对青少年早期抑郁的交互作用

本研究运用问卷法与DNA分型技术,对1063名青少年(初次测评年龄为12.32±0.47岁,50.3%女生)进行间隔2年的追踪调查,考察DRD2基因TaqIA多态性与同伴身体侵害和关系侵害对青少年早期抑郁的交互作用及其性别差异。结果发现,TaqIA多态性与身体侵害、关系侵害均对男青少年抑郁存在显著的交互作用。在携带A2A2基因型的男生中,身体侵害和关系侵害可以显著正向预测其抑郁水平,而在携带A1等位基因的男生中,同伴侵害对抑郁无预测作用。此外,TaqIA多态性与身体侵害、关系侵害对女生抑郁均无显著交互作用。研究结果提示,同伴侵害是一种重要的候选环境指标,与TaqIA多态性交互影响青少年早期抑郁,并且性别在这一基因×环境交互作用中起到重要的调节效应。     

儿童期受虐经历与抑郁的元分析

本研究采用元分析技术探讨儿童期虐待亚类型与抑郁的关系。通过文献搜索与检查获得了31项研究和92个独立效应量,共包含24283名被试。元分析表明儿童期虐待亚类型(心理虐待与忽视、性虐待、身体虐待与忽视)对抑郁障碍存在不同程度的影响,其中心理虐待与忽视影响程度最高;另外,被试的年龄、性别可以调节儿童期虐待与抑郁的关系。这些结果表明了在预防和治疗儿童期不良经历对抑郁影响时,尤其要关注心理虐待与忽视的消极影响,且应给予青少年群体、女性更多的关注和保护。     

基于技术接受模型的青少年网络游戏成瘾机制研究

本研究以技术接受模型(TAM)为理论框架, 通过对380名中学生的问卷调查考察了青少年网络游戏成瘾的影响因素及其机制。结果发现:(1)有用感、易用感、品质感知、游戏体验和态度与网络游戏成瘾显著正相关;(2)品质感知和游戏体验通过态度的部分中介作用对网络游戏成瘾产生间接影响, 同时对网络游戏成瘾有直接效应;有用感和易用感通过态度的完全中介作用对网络游戏成瘾产生间接影响, 对网络游戏成瘾没有直接效应。本研究结果表明, 品质感知、有用感、易用感和游戏体验对青少年网络游戏成瘾具有重要影响, 态度是其中的重要中介变量。     

MAOA基因rs6323多态性与同伴关系对男青少年早期抑郁的影响

以683名男青少年为被试(初次测评时M = 13.35岁; SD = 0.51), 综合运用传统回归分析和新兴显著性区域检验, 考察了MAOA基因rs6323多态性与同伴关系对青少年早期抑郁的交互作用及其表现形式。结果表明：当同伴接纳水平较低时, G等位基因携带者的抑郁水平表现出高于T等位基因携带者的趋势, 当同伴接纳水平较高时, G型基因携带者的抑郁水平显著低于T等位基因携带者; 同伴接纳可以显著预测G等位基因携带者的抑郁, 但对T等位基因携带者的抑郁无显著预测作用; rs6323多态性与同伴拒绝的交互作用亦不显著。研究结果提示, 同伴关系对MAOA基因与男青少年早期抑郁的关联起调节作用, 且其作用形式部分支持不同易感性模型观点。     

青少年科学创造力的理论研究与实践探索

系统梳理了20年来青少年科学创造力的理论研究与实践探索,包括概念与结构、测量与发展、影响因素和机制、培养思路与模式等,分析了科学创造力研究的趋势,提出了若干重要的研究方向。在未来的研究中,要加强几个方面的研究工作,即科学创造力的认知神经机制研究,科学创造力的基因组学研究,基于情境和内容的科学创造力研究,教学活动或项目促进科学创造力发展的神经可塑性机制研究,以及基于聚合科技的科学创造力培养。     

经颅直流电刺激在抑郁症治疗中的应用

已有的神经影像学研究成果揭示, 抑郁症发作的重要原因之一是大脑前额叶皮层结构和功能受损。经颅直流电刺激(tDCS)作为一种无创脑刺激, 选取前额叶皮层作为刺激区域, 通过调节皮层兴奋性来治疗抑郁症, 能够有效缓解抑郁症状和改善受损的认知功能, 疗效明显且持久稳定。针对tDCS在抑郁症治疗研究中的问题, 未来可从有效性、个体差异以及预防干预等六个方面进一步研究, 以期tDCS作为一种具有潜力的治疗手段, 在临床上有更为广泛地应用。     

亚健康中抑郁程度人群分布特点的对应分析

为了分析亚健康人群抑郁的不同表现程度与不同人口学资料的关系,采用"亚健康状态的测量及诊断标准研究"课题组调查的中国人亚健康资料,利用对应分析对抑郁表现因子总分的不同等级与不同的年龄、婚姻、职业和学历的关系进行分析。结果显示,20岁～30岁、未婚、学生和大专及以上学历主要表现为中重度抑郁倾向,31岁～40岁、已婚、专业人士和高中专学历主要表现为中度抑郁倾向,41岁～60岁、工人、农民和初中以下学历的抑郁倾向较轻,结论为亚健康人群的心理不适,特别是抑郁倾向,主要集中在年龄较轻、学历较高的专业人士和白领人群当中,还包括大学生群体,我们应该针对这些群体采取相应的措施减轻他们的心身不适。