高血压治疗:百年历程、日益细化

人类对高血压的治疗是百年以来医学的重要成就.越来越多的证据表明,有效控制高血压是降低相关疾病发病、死亡、致残的重要手段.医学对高血压治疗药物、手段、方案的探索尚未止步,许多正在进展中.     

Cognitive Behaviour Therapy and Recovery from Acute Psychosis: Case Studies of Two Contrasting Styles

In the North Wales randomised controlled trial of cognitive behaviour therapy (CBT) for acute schizophrenia spectrum disorders, patients who received CBT as an adjunct to treatment-as-usual (TAU) had significantly better outcomes at 12 months than patients who received only TAU. However, patients who were offered CBT but dropped out of treatment early had outcomes that were no worse than patients who stayed in. The explanation for this curious finding might be that the drop-outs and the stay-ins had different but equally valid recovery styles. Two case studies from the trial are presented to illustrate these recovery styles: sealing-over and integrating. Discussion focuses on the idea that, rather than try to alter patients' recovery styles, a more appropriate aim might be to match treatment to the patients' styles.     

两种水化疗法对预防对比剂肾病的效果研究

比较两种水化疗法对对比剂肾病(contrast-induced nephropathy,CIN)的预防效果。将150例患者随机分为氯化钠水化组(50例)、碳酸氢钠水化组(50例)和常规治疗组(50例),检测患者造影前3天内及造影后第3天、7天的血肌酐、尿素氮和尿β2微球蛋白。分析三组患者CIN的发病率。结果两水化组CIN的发病率均显著低于常规治疗组(P0.05),两水化组间CIN的发病率无明显差异(P0.05)。结果提示两种水化疗法对CIN的预防效果相仿。     

左主干或多支冠脉病变的选择:PCI或CABG?

近年来,PCI技术越来越多地实践于左主干和多支冠脉病变,但与CABG相比,其疗效一直受到质疑。本文对近年来PCI和CABG的疗效比较做一总结,发现对于左主干和冠脉多支病变,CABG仍优于PCI。但随着生产力水平的发展和社会需求越来越高的双重作用下,两项技术都必然会有新的发展,两者疗效的比较还会继续,我们将拭目以待。     

我国酒精性肝病的医学困惑与应对策略

酒精性肝病是导致我国肝脏损害的第二大原因,已成为最严重的健康问题之一。我国已经迎来了酒精性肝病的高峰时期,并将会持续增长,卫生系统将面临巨大的压力。然而,对于酒精性肝病本身,还存在着诊断、治疗、预防等众多医学困惑;饮酒的危害不仅仅局限在肝脏,还可引起全身多器官的损害;酒害也早已超越了医疗界,是一个严重的社会问题。对于酒精性肝病的防治需要全社会共同参与,并且将是一条极其漫长而艰难的路程。     

Cultural conceptions of a bereavement-related illness in a South African indigenous community

This study explored cultural conceptions of a bereavement-related illness among elderly (aged 34–85yrs) Northern Sotho-speaking people in Limpopo province. The participants (n = 14, females = 50%, mean age = 59 years, SD: 13.7 years) were purposively selected and interviewed using in-depth interviews. Data were analysed using Hycner’s adapted phenomenological method. Three themes emerged from the analysis: debilitating and life-threatening symptoms of the illness; aetiology explained by ritual taboo violations; and management of the illness through ritual cleansing. The cleansing process incorporates the administration of traditional herbs. The findings suggest bereavement-related illness in an African cultural community to be explained by their cultural concept of distress understandings.     

Utilization Behavior: Clinical Manifestations and Neurological Mechanisms

This paper describes a variety of motor release phenomena, including manual grasping and groping, imitation behavior, utilization behavior, and alien hand sign, their clinical manifestations, and proposed neural mechanisms. One of these specific neurobehavioral disorders, initially described by Lhermitte (Brain [1983] 106: 237–255), and termed utilization behavior, is addressed in more detail. Patients with this disorder are described as reaching out and using objects in the environment in an automatic manner. The current paper provides a comprehensive review of studies that have documented utilization behavior in individuals with a variety of pathologies, all having a specific predilection for the frontal lobes and frontal-striatal systems. Goldberg's (Behavioral and Brain Sciences [1985] 8: 567–616) theoretical framework for understanding motor release phenomena, which conceptualizes these behaviors as resulting from an imbalance between proposed medial (voluntary, goal directed, and future directed) and lateral (automatic, stimulus bound, and visually based) motor systems, is also discussed. Utilization behavior may prove to be a common underlying cause of high levels of excessive and intrusive motor behaviors within various clinical populations. A more comprehensive understanding of the neural systems underlying utilization behavior may prove highly useful for the differential diagnosis of conditions involving the mesial frontal cortex and fronto-striatal connections. Recent studies have started to investigate utilization behavior in clinical populations with known or suspected frontal system dysfunction, including adult patients with a variety of psychiatric conditions and children with ADHD.     

心理咨询热线在突发性公共卫生事件中的应用分析

2003年SARS在中国一些地区的流行给社会公众在心理上带来了一定程度的影响,在SARS流行期间期间及时开通了面向公众的心理咨询热线,成为了广大公众寻求心理支持的有效途径,为缓解社会压力、促进社会正常秩序恢复起到了积极作用。该文结合中国科学院心理研究所“非典心理咨询热线”的统计数据,进一步探讨了心理咨询热线在应对突发性公共卫生事件中的作用和工作特点。     

Acute effects of alcohol on cardiovascular reactivity to stress in college-age Type A (coronary prone) individuals

Healthy college-age males and females classified as Type A or Type B were randomly assigned to an alcohol (N=24) or a no-alcohol condition (N=24). Subjects were exposed to a verbal stress quiz while blood pressure, heart rate, peripheral vascular response (PVR), and self-reported anxiety indices were monitored. Results indicated that alcohol effected a reduction in resting levels of systolic blood pressure and a tonic reduction in the peripheral vascular response. Alcohol attenuated the systolic blood pressure, heart rate, and PVR to stress and efffected a decrease in anxiety following the Stressor. When analyzed relative to the participants' drinking experience, data indicated that the strongest stress-modulating effect of alcohol was evidenced by Type A subjects who have been identified as long-term drinkers. During recovery from stress Type A subjects identified as short-term drinkers maintained high levels of PVR. Types A and B subjects who did not ingest alcohol evidenced high PVR levels during stress. The findings are discussed in terms of the protective action of moderate chronic alcohol use on cardiovascular disease risk reduction in persons evidencing the coronary-prone behavior pattern.     

Constant vigilance: Heritage values and defensive pessimism in coping with severe acute respiratory syndrome in Singapore

The present study investigates the congruency of defensive pessimism in the Asian context and its role in coping with the severe acute respiratory syndrome (SARS) crisis in Singapore. Data collected from 174 Singaporeans supported the hypothesized relationships among Chinese values, defensive pessimism, SARS-related fears, compliance to preventive health-related behaviors and negative outcomes. Path analysis revealed that individuals' endorsement of Chinese value clusters − prudence, industry, and civic harmony − positively predicted their levels of defensive pessimism. The results also indicated that defensive pessimism had a direct positive effect on SARS-related fears and, SARS-related fears, in turn, were directly related to direct preventive health-related behaviors but not related to indirect preventive behaviors. In addition to the indirect effect of Chinese values on direct preventive health-related behaviors, Chinese values had a direct positive effect on both direct and indirect preventive health-related behaviors. Consistent with our contention that defensive pessimism has the potential for leading to particular negative outcomes, defensive pessimism was found to influence negative outcomes but this relationship was partially mediated by SARS-related fears.