液体潴留量与重症急性胰腺炎早期并发ARDS相关性临床分析

探讨48h液体潴留量〉4000ml与重症急性胰腺炎（SAP）早期并发急性呼吸窘迫综合征（ARDS）的临床相关性,为进一步指导11盏床SAP患者早期液体复苏治疗并预防急性肺损伤提供科学依据。回顾性分析我院2012年1月至2014年1月收治的43例SAP患者临床资料,并进行统计学处理。分析结果表明48h液体潴留量〉4000m1与sAP早期并发ARDS呈现出明显的正相关,48h液体潴留量〉4000ml的sAP患者早期并发ARDs的危险性是48h液体潴留量〈4000ml的SAP患者的14．4倍,48h液体潴留量〉4000ml是重症急性胰腺炎早期并发ARDS的高危险因素。对于SAP患者在早期临床治疗过程中应密切注意液体潴留量,通过合理补液可降低sAP并发ARDS的发生率和病死率。     

急性冠脉综合征患者血液Rho激酶活性分析

探讨 Rho 激酶（ROCK）活性与急性冠脉综合征（ACS）患者冠状动脉狭窄程度及预后的关系。选取2012年6月至2013年3月住院的129例患者,其中急性心肌梗死（AMI）组68例、不稳定型心绞痛（UA）组30例、对照（CON ）组31例。Western Blot 检测血液白细胞中 ROCK 、ROCK1、ROCK2活性,同时根据冠状动脉的狭窄程度及是否发生心血管意外分组再次比较。 AMI 组和 UA 组 ROCK 、ROCK1、ROCK2活性均增高;且 AMI 组高于 UA 组;三支、双支、单支病变组活性依次减低,Gensini 评分≥20分组及发生心血管意外组均高于 Gensini 评分＜20分组及未发生心血管意外组,差异均有统计学意义（P＜0．05）。 ROCK 活性可能对 ACS 患者预后观察、评估有重要意义。     

A dynamic view of cultural influence: A review

Static models of culture's influence have given way to a dynamic view, which identifies not only differences across cultures in people's judgments and decisions, but also the situations and conditions in which these differences do or do not appear. Theory and evidence developed from a cognitive psychological perspective underlie this dynamic approach, including research emerging from the “dynamic constructivist” and “situated cognition” models. In the present review, we focus on findings that confirm the utility of this cognitively oriented approach, and briefly discuss the advantages and complementary nature of the “social collective” and neuroscience approaches to understanding culture.     

DS14 is more likely to measure depression rather than a personality disposition in patients with acute coronary syndrome

It has been suggested that Type D Personality is a risk factor for acute coronary syndrome (ACS) and the DS14 has been developed for its assessment. However, some of the items on the DS14 seem to evaluate depressive symptoms rather than personality features. Therefore, the present study aims to verify whether an overlap exists between the constructs of Type D Personality and depression. Three‐hundred‐and‐four consecutive patients who were both presenting their first ACS and had no history of major depression completed the Hospital Anxiety and Depression Scale (HADS) and the DS14 to assess Type D personality at baseline and have been re‐evaluated at 1, 2, 4, 6, 9 and 12‐month follow‐ups. Out of 304 subjects (80.6% males), 40 were diagnosed as depressed. An exploratory factor analysis of HADS and the DS14 in the second month revealed that four out of seven items on the depressive subscale of HADS (HADS‐D) and six out of seven items on the Negative Affectivity (NA) subscale of the DS14 segregated on the same factor. Results were verified by a Partial Confirmatory Factor Analysis performed at the twelfth month when most of the patients achieved complete remission from the depressive episode. Temporal stability was poor for NA and Type D Personality and these construct co‐vary with HADS‐D over time. Our data suggests that NA and depression are overlapping constructs, supporting the idea that the DS14 measures depressed features, rather than a personality disposition.     

Patient preferences for medicine administration for acute agitation: results from an internet-based survey of patients diagnosed with bipolar disorder or schizophrenia in two Nordic countries

The objective was to elicit patient preferences for medicine administration method in the management of acute agitation episodes among patients diagnosed with bipolar disorder or schizophrenia. The patients’ experiences of acute agitation episodes and their management of episodes were also explored. Data were collected via an anonymous, internet-based survey of residents in Denmark or Sweden with schizophrenia or bipolar disorder (October 2014 to December 2014). Inclusion criteria were having a diagnosis of schizophrenia or bipolar disorder, and being above 18 years of age. The questionnaire included questions about preferences for medication attributes, experiences with pharmacological treatment for agitation and involvement in treatment plans. A total of 237 diagnosed patients (61 with schizophrenia; 176 with bipolar disorder) completed the questionnaire. Agitation episodes were experienced by 90% of the respondents. In total, 83% of the respondents reported having received treatment with tablets. When patients were presented with the attributes of an inhalation method, respondents stated that the fast onset of action, low risk of adverse reactions and least invasive form of drug delivery were positive attributes of treatment with inhalation. Inhalation is a new delivery route for treatment of acute agitation in patients diagnosed with bipolar disorder or schizophrenia. Inhalation is the preferred treatment method for acute agitation among Danish and Swedish patients with bipolar disorder or schizophrenia.     

急性一氧化碳中毒高压氧治疗的中美指南比较

急性一氧化碳（carbonmonoxide,CO）中毒是中美最常见的意外中毒原因之一。高压氧能促进碳氧血红蛋白解离,加速体内CO排出,明显缩短CO半清除时间,是治疗急性CO中毒的一种重要治疗方法。比较中美现有急性CO中毒治疗指南及推荐意见。发现其中在高压氧治疗应用的适应证、具体方案、治疗费用等方面有很大差异。我们对此差异进行比较分析,为临床治疗及科研提供参考,也对通过进一步研究以充分证实高压氧治疗急性CO中毒的有效性,制订高压氧治疗最佳方案提出展望。     

Perseverative thoughts and subjective health complaints in adolescence: Mediating effects of perceived stress and negative affects

Stable tendency to perseverative thoughts such as trait rumination and worry can influence somatic health. The purpose of the study was to investigate the relationship between perseverative thoughts and somatic complaints, and the possible mediating effects of perceived stress, negative and positive affectivity in adolescence. Having an acute or a chronic condition was also assessed to be controlled for and to reveal their effects on symptom reporting. Three hundred and six adolescents from 7th to 12th grade with mean age of 16.33 (SD = 1.29) participated in the study. Mediation analysis suggested that impact of trait-like perseverative thoughts on complaints were mediated by perceived stress and negative affectivity. Having an acute condition had also an effect on symptom reporting through increased negative affectivity. Our results highlight that ruminations or worry as stable intrapersonal characteristics are relevant processes in health and can be potential targets in prevention programmes in adolescence.     

The psychosocial predictors of long-term distress in partners of patients with acute coronary syndrome

Objective: Partners of acute coronary syndrome (ACS) patients are at risk of experiencing long-term distress and the purpose of this study was to identify its predictors.

Design: Using an observational design, 80 partners of ACS patients completed validated questionnaires at three time points. The predictor variables, marital satisfaction and optimism were assessed three weeks after patient hospital discharge (T1). The outcomes, depressive symptoms and physical health status (from a quality of life scale) were measured 6 (T2) and 12 (T3) months post-discharge, and scores were combined to indicate the long-term response.

Main outcome measures: Depressive symptoms and physical health status.

Results: Partner depressive symptoms increased and physical health status deteriorated over the months following the patients’ ACS. After controlling for demographics, clinical severity of ACS and T1 levels of the outcome variable, partners’ long-term depressive symptoms were predicted by poor marital satisfaction and low optimism at T1, and poor physical health status was predicted by low T1 optimism.

Conclusion: Psychosocial factors are predictors of long-term distress for ACS partners. Partners in an unhappy marriage or with low optimism after ACS are at an increased risk of depression and low physical health status, and should be the target of additional support.     

Type a behaviour,social contact and coronary death

Abstract

The risk of coronary death associated with Type A behaviour (Framingham definition) and social contact was examined using a retrospective case-control design. Logistic regression analysis of 134 male cases and 339 controls showed that increased risk was associated with Type B behaviour, and independently with limited social contact. Discussion focuses on issues surrounding the use of retrospective, proxy data; and on the speculation that Type A behaviour may increase risk of non-fatal coronary events, but protect against coronary death.     

Cognitive predictors of posttraumatic stress symptoms six months following acute coronary syndrome

This study examined patients’ illness representations assessed shortly after an acute coronary syndrome (ACS) as predictors of posttraumatic stress symptoms six months later. Illness representations were assessed in ACS patients using standard measures at a home visit three weeks after discharge from hospital. Posttraumatic stress symptoms were assessed at the same time, and again six months later. Patients were aged 61 years on average, the majority being men (89.8%) of white European decent (89%). Greater posttraumatic symptoms at six months were associated with beliefs that the illness would last a long time (timeline), that it had an unpredictable time course (timeline – cyclical), greater consequences, less personal and treatment control, poorer illness coherence and stronger negative emotional representations (emotional upset relating to the illness; p?<?0.05). In multiple regression analyses, controlling for demographic, clinical and psychological factors (age, gender, ethnicity, social deprivation, ACS severity, negative affectivity and cardiac symptom recurrence), more intense emotional representations (β?=?0.146, p?=?0.041) and reduced illness coherence (β?=??0.133, p?=?0.029), emerged as independent predictors of posttraumatic symptom severity at six months. There was a near significant effect for personal control (β?=??0.113, p?=?0.058). These results demonstrate the importance of illness representations of ACS in predicting longer-term posttraumatic stress symptoms.