干细胞移植治疗冠心病的现状与未来

冠心病仍然是全球的主要死亡原因。其所造成的心肌梗死及慢性心力衰竭对生活质量的影响和由此造成的高额医疗费用促使我们不断寻求新的医疗措施。近几年有关干细胞用于心肌梗死后心肌再生、心肌内新生血管形成,可能还会改善梗死后的心功能的研究成为心脏病学研究的最热门领域。尽管干细胞治疗有可能使心力衰竭的治疗得到彻底的革命,但仍有部分问题需要澄清。已发表的各个研究结果设计不尽相同,致使对该项治疗的效果较难得出一致的结论。但这些研究都强调干细胞治疗在未来心血管疾病的治疗中可能会发挥较大的作用。干细胞治疗与药学、外科及介入治疗的结合会显著改善冠心病患者的预后。     

流式细胞术在骨髓增生异常综合征及再生障碍性贫血诊断中的应用

为探讨骨髓增生异常综合征患者与再生障碍性贫血患者骨髓髓系细胞的免疫表型变化,用流式细胞术检测骨髓增生异常综合征、再生障碍性贫血及正常对照髓系细胞的表面抗原。结果显示骨髓增生异常综合征组髓系细胞较正常对照组及再生障碍性贫血组表面抗原表达明显不同。因此,流式细胞术有助于二者的诊断及鉴别诊断。     

急性应激影响工作记忆的生理心理机制

急性应激是机体面对外界环境变化所产生的一系列生理和心理反应, 对认知加工, 尤其是核心的工作记忆能力产生深远影响, 然而以往的研究存在大量不一致的结果。从应激诱发方式、工作记忆加工子成分、个体差异等三个方面系统阐释应激影响工作记忆的生理心理机制, 并结合认知神经机制的框架, 可以更好地理解以往的结果。未来研究应综合考虑应激诱发、认知任务和响应个体等方面的差异对应激带来的影响, 并关注急性应激负面影响的干预与调控。     

State gratitude for one’s life and health after an acute coronary syndrome: Prospective associations with physical activity,medical adherence and re-hospitalizations

Abstract

Gratitude may be associated with beneficial health outcomes, but studies of this association have been mixed, and in these studies gratitude has often been conceptualized as a stable, unidimensional trait. We used four specific items to examine the prospective association of state- and domain-specific gratitude with medical outcomes among 152 patients with a recent acute coronary syndrome. State gratitude for one’s health 2 weeks post-event was associated with increased physical activity (measured via accelerometer) 6 months later, controlling for relevant demographic, social, medical and psychological factors (β = 340.9; 95% confidence interval = 53.4–628.4; p = .020). Gratitude for one’s life was associated with increased self-reported medical adherence at 6 months on the maximally adjusted model (β = .60; 95% confidence interval = .16–1.04; p = .008); no gratitude items were associated with rehospitalizations. In contrast, dispositional gratitude, measured by the Gratitude Questionnaire-6, was less dynamic and responsive to change over the 6-month period and was not associated with physical activity.     

Perceptions of Submissiveness: Implications for Victimization

Some researchers have suggested that a precondition of affective submissiveness may increase the likelihood of female victimization in sexual assault, whereas others have suggested that criminal offenders use perceptions of vulnerability when selecting a victim. In this study, based on American college students, men (decoders) rated videotaped women (encoders) dominant versus submissive using a semantic differential instrument. Cue evaluators analyzed the body language and appearance of the videotaped women using a Likert instrument. The results suggest that (a) men form differentiated perceptions of dominant versus submissive women, (b) such perceptions substantially rely on nonverbal cues, (c) dominant and submissive women display visually different behaviors and appearances, and (d) men tend to select submissive females for exploitation.     

Extending fields of work

The aim of this paper is to describe some acute responses to the suicide of a parent, through the account of the analytic psychotherapy of a latency child who found the body of his dead father. The acute traumatic responses of the child show that the perceptual apparatus, time and space are subverted, while the functioning of the contact barrier is deeply damaged. The importance of the environment in facilitating the first stages of the mourning process is stressed as well as the pre-traumatic personality structure. Both the Bionian model of preconception and the post-Jungian notion of archetype, revisited in terms of an unsaturated predisposition, are considered from a theoretical point of view. Preconceptions and archetypal dispositions to survive traumatic events are very important to the therapeutic outcome, along with the opportunity to start the treatment as early as possible after the traumatic event. This is particularly relevant in relation to the latency period, in terms of the capacity to contemplate the effects of the drives. The importance of allowing the child to work through all the stages of mourning is also considered, particularly rage, protest and hostile fantasies towards the lost object. The clinical material is structured as a narrative in an attempt to evoke the emotional climate experienced during the sessions as well as the state of mind of the child. The narrative is a secondary elaborated account with condensation and displacement at its core, like in dream work. Events, filtered through the analyst's state of self, are reported by lending the first person to the child in the narrative reconstruction.     

3例误诊为急性冠脉综合征实施介入诊治死亡病例的启示

探讨3例被误诊为急性冠脉综合征（ACs）而急诊实施介入诊治死亡病例的,搭床特点及误诊原因,提高对ACS的诊断意识。收集我院比较典型的3例误诊死亡病例进行回顾性分析。3例死亡病例中1例为肺栓塞、1例为主动脉夹层动脉瘤（AD）、1例为流行性出血热,3例均实施了冠状动脉造影,1例于前降支植入了1枚支架。ACS患者临床表现复杂,误诊原因多为首诊医师思路狭窄,应充分利用现代影像技术,仔细分析临床症状和体征,可减少误诊死亡的发生。     

单纯糖耐量受损的冠心病患者临床及冠脉造影特点分析

入选空腹血糖正常并通过冠脉造影（CAG）确诊为冠心病（CAD）的患者104例行糖耐量试验（OGTT ）,将糖耐量正常（NGT ）者、单纯负荷后2h 血糖受损者（I-IGT ）与同期合并糖尿病（DM ）并通过 CAG 确诊为 CAD 的患者38例对照。结果,（1）DM 组甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（LDL-C）、载脂蛋白（Apo）、高敏-C 反应蛋白（hs-CRP）、尿微量白蛋白、尿酸（UA）高于 NGT 组（P＜0．05或 P＜0．01）,且 I-IGT 组体质量指数（BMI）最大,与 NGT组及 DM 组比较有统计学意义（P＜0．01）;（2）I-IGT 、DM 组冠状动脉病变支数、重度狭窄、闭塞、弥漫性病变、病变总积分、右冠状动脉病变比例均高于 NGT 组（P＜0．05或 P＜0．01）;（3）DM 组三支病变、弥漫性病变、冠状动脉病变总积分均高于 I-IGT 组（P＜0．05）。因此,空腹血糖正常的 CAD 患者均应行 OGTT 检查,以降低糖耐量异常的漏诊率;I-IGT 患者发生心血管疾病的危险性增加,且随着糖代谢异常的加重而加剧,应及早干预。     

冠心病介入治疗指南与医生的理解、掌握与运用的冲突和平衡

介入治疗是冠心病治疗的重要手段,介入治疗时机、方式、介入手术和外科手术以及内科治疗的选择,是关系到患者生命的首要问题。现从循证医学及冠心病治疗指南与医生的理解、掌握与运用的角度,探讨有利于患者的医疗行为。在临床工作中寻求医生对指南的理解、运用的一致和平衡。     

高尿酸血症与冠心病之间的关系

高尿酸血症是一种嘌呤代谢障碍性疾病,早期人们主要关注高尿酸血症对关节及肾脏的影响,但随着尿酸水平的升高,患心血管疾病的风险也相应的增加,近年来越来越多的研究用于证明高尿酸血症与心血管疾病之间的相互作用,人们才逐渐关注高尿酸血症对心血管疾病的影响,并且一直是学者关注的焦点之一,高尿酸血症是否为冠心病的独立危险因素？高尿酸血症是否直接和冠心痛的预后相关？两者之间的关系一直存在争议,本文就高尿酸血症与冠心病关系、高尿酸血症对冠心痛影响的可能机制作一综述.