冠心病调脂治疗过程中的哲学思考

他汀广泛用于冠心病的一级预防和二级预防,普遍源于循证医学的证据。首先,他汀治疗冠心病是从疾病的本质出发,采取有效方法稳定斑块、缓解缺血。调脂治疗中,以降低低密度脂蛋白胆固醇为主要目标,体现了抓主要矛盾和矛盾的主要方面的思路。调脂强调联合治疗,个体化治疗,同时一分为二看待药物的作用,适时减量或停药。     

中青年冠心病患者冠脉介入治疗后精神心理改变及影响因素调查分析

应用焦虑、抑郁自评量袁对84例行冠脉介入治疗的中青年冠心病患者分别进行术前、术后3个月的问卷调查,分析其变化的影响因素后进行综合评价。发现此类人群大多有焦虑、抑郁倾向,其发病率与性别有关而与年龄无关;其影响因素与对疾病的认识、医疗保险、家庭结构有一定相关性。     

2010年我国急性ST段抬高型心肌梗死诊断与治疗指南解读评析

近年来我国急性心肌梗死的发病率一直呈明显上升趋势,已接近国际平均水平。对于STEMI版早期诊断并及时开通梗死相关动脉、增加心肌再灌注、防止心肌进一步坏死,可显著降低心血管事件的发生。本文从STEMI的诊断、早期医疗、再灌注治疗、辅助治疗及二级预防等几个方面对2010年我国急性ST段抬高型心肌梗死的诊断与治疗指南进行了详细解读分析。     

从指南看冠心病降脂治疗的现状及分析

层出不穷的试验研究和不断更新的指南使人们对冠心病防治的认识不断加深,但指南的实施和普及却不理想,大多数冠心病患者并未真正受益于降脂治疗。现就NCEP-ATP指南的更新和目前冠心病患者降脂治疗的现状、主要影响因素(患者的依从性、医务工作者的医疗质量、药物有效性以及效价比与经济条件)及可能的改善措施做一综述。     

冠心病诊治中的过度医疗

近年来,过度医疗问题引起了医学伦理学界的普遍关注。过度医疗是一个经济现象,同时也是一个伦理问题．确切的说是一个医学一社会问题。结合冠心病过度医疗的特点,从医学伦理学角度剖析冠心病过度医疗的原因,并提出了医者、患者、医疗机构和社会针对冠心病过度医疗应采取的措施。     

医学对急性呼吸窘迫综合征（ARDS）的认识

ARDS是一个临床综合征,其特征是炎症性肺水肿,严重的低氧血症,僵硬肺和弥漫性内皮和上皮损伤。既往50年中,特别是SARS在全球暴发以来,对ARDS病因、生理学、组织学和管理上有了重大的进展。然而,尽管围绕ARDS的研究显著增加,依然有许多重要问题亟待解决。     

Religious beliefs,patient–doctor interaction and resilience as predictors for treatment decisions and health outcomes of heart patients

Treatment decision-making in chronic illness poses long-lasting effects on the health status of patients. In Western individualistic cultures, they are independently taken by the individual in collaboration with doctors contrary to the collectivistic Indian context, where it’s decided by families with little or no involvement of patients. Religious beliefs, patient–doctor interaction, and resilience measures of 100 CAD patients were used to assess their religious beliefs, patient–doctor interaction, and resilience (predictors). Hierarchical Regression Analysis was conducted to test for the significance of the proposed model. Religious beliefs, patient–doctor interaction, and resilience collectively predicted the significant change in decision-making styles, somatic symptoms, anxiety, social dysfunctions, depression, and general health total of the participants. While the treatment decision-making is heavily contingent upon the social factors namely – religious beliefs, patient–doctor interaction, and resilience, there may yet be some underlying psychological factors that have not been explored in the present study.     

系统论视角下重型急性胰腺炎的治疗

重症急性胰腺炎(severe acute pancreatitis,SAP)是临床上常见的急腹症之一,本文试从系统生物学角度出发,探讨其在SAP营养支持治疗、抗生素的选用以及外科手术治疗中的应用。强调应用整体的、综合的、发展的观点去研究SAP的治疗,从而找到最佳治疗方案。     

Neuropsychological Functioning Associated with High-Altitude Exposure

This article focuses on neuropsychological functioning at moderate, high, and extreme altitude. This article summarizes the available literature on respiratory, circulatory, and brain determinants on adaptation to hypoxia that are hypothesized to be responsible for neuropsychological impairment due to altitude. Effects on sleep are also described. At central level, periventricular focal damages (leuko-araiosis) and cortical atrophy have been observed. Frontal lobe and middle temporal lobe alterations are also presumed. A review is provided regarding the effects on psychomotor performance, perception, learning, memory, language, cognitive flexibility, and metamemory. Increase of reaction time and latency of P300 are observed. Reduced thresholds of tact, smell, pain, and taste, together with somesthetic illusions and visual hallucinations have been reported. Impairment in codification and short-term memory are especially noticeable above 6,000 m. Alterations in accuracy and motor speed are identified at lower altitudes. Deficits in verbal fluency, language production, cognitive fluency, and metamemory are also detected. The moderating effects of personality variables over the above-mentioned processes are discussed. Finally, methodological flaws found in the literature are detailed and some applied proposals are suggested.     

Negative emotions and coronary heart disease: Causally related or merely coexistent? A review

Negative emotions have been claimed to be a cause of coronary heart disease (CHD) as well as a consequence of cardiovascular disorders. Early case studies of cardiac disorders of soldiers in battle drew attention to the possibility that strong negative emotional states could cause CHD. Subsequent reports of reactions to natural disasters supported the notion that intense negative emotions could precipitate somatic disorders such as CHD. Since then, numerous studies have investigated relations between negative emotions and CHD. Over the years, retrospective studies have found, for example, that negative emotions are often present before the occurrence of CHD. Cross-sectional studies have indicated that symptoms of depression and anxiety are often present in CHD patients. Prospective studies have shown that the likelihood of CHD tends to be higher for people with negative emotions than for those without them. The main symptoms of negative emotional states that seem to be most closely associated with CHD are nervousness, getting easily upset, feeling fatigue, being indecisive, having sleep disturbances, being usually worried about something, and feeling that others would be better off if oneself were dead. Although the findings appear to support the notion of causal connections between negative emotions and CHD, they fail to provide conclusive proof of such relations. An alternative explanation that could also account for the findings is simply that negative emotions and CHD often coexist.