肺保护策略机械通气的再评价

通常认为急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)患者应用肺保护策略机械通气可降低病死率,主要由于潮气量的降低。对已发表的随机对照研究再次分析,发现平台压与患者病死率明显相关。平台压低于30cmH2O时,潮气量可以在一定范围内增加,不影响患者预后。但选择小潮气量可能对病人有害。随机对照研究在试验设计、统计学分析、病人同质性等方面依然存在很多问题。从现有资料看,潮气量和平台压都很重要。     

应激心向对女性急性应激条件下工作记忆的影响

为了探讨急性应激对工作记忆的影响,本研究引入应激心向的概念。实验1验证了社会性评价冷压测试的可靠性以及应激对工作记忆的影响,并探讨了急性应激条件下一般性应激心向与工作记忆的关系,结果发现,在急性应激条件下,女性的一般性应激心向不影响工作记忆的表现。实验2通过视频诱发被试的情境性应激心向,发现应激有利心向组比应激有害心向组在工作记忆任务中的表现更好,且应激心向得分与任务的准确率成正相关。研究表明女性在应激条件下的工作记忆表现会受具体应激心向的影响。     

Inhibition of endogenous carbon monoxide production induces transient retention losses in the day-old chick when trained using a single trial passive avoidance learning task

Carbon monoxide (CO) is most often thought of as an exogenous toxin rather than as a possible endogenous nootrope. However, a limited number of studies have suggested that CO is necessary in memory processing for at least some tasks. While nitric oxide (NO) and CO are known activators of guanylyl cyclase (GC), only the effect of NO on GC has been extensively investigated as a mechanism underlying memory processing. The aim of the present study was to determine if inhibition of CO production would have an effect on memory processing. Using chicks trained on a single trial passive avoidance task, inhibition of CO production using zinc (II) deuteroporphyrin IX 2,4-bis ethylene glycol (ZnBG; 5 microM) resulted in two transient retention losses occurring at around 40 and 130 min post-training. The timing of these transient retention losses was similar to those observed following inhibition of GC, using the same species and task in a previous study. This supports the notion that CO is necessary in memory processing for this task and may act through a GC-dependent mechanism. As ZnBG also directly inhibits GC or nitric oxide synthase (NOS) at high concentrations, a second experiment was carried-out to confirm the specificity of ZnBG for heme oxygenase (HO) at the concentration used. The action of ZnBG was challenged with the HO agonist hemin (100 microM) and the transient deficits were abolished. This confirmed that the action of ZnBG on memory was through a CO-related mechanism rather than directly on GC or NOS. In this way the specificity of ZnBG (5 microM) for HO could be confirmed. The results support a role for endogenous CO in memory processing, possibly through activation of GC. In addition, the transient retention losses observed following administration of ZnBG suggest that CO may be necessary for memory retrieval and not formation as previously thought.     

急性前壁心肌梗死患者直接PCI后阿托伐他汀不同用药剂量疗效比较

为探讨直接经皮冠状动脉介入治疗（PCI）首次急性前壁心肌梗死患者,在不同剂量他汀药物治疗后住院期间疗效比较,纳入首次诊断为急性前壁心肌梗死并接受直接PCI治疗的患者140例,随机分为强化治疗组和对照组。强化治疗组入院时顿服阿托伐他汀80mg,术后40mg／晚,直至出院;对照组口服阿托伐他汀20mg／晚。术前及术后、出院前测定心肌标记物,术前及出院前测定血浆氨基末端B型利钠肽前体（NT—proBNP）,采用彩色多普勒超声检测左室射血分数（LVEF）的变化,同时记录住院期间主要心脏不良事件（MACEs）的发生。结果出院时LVEF值差异无统计学意义（P=0．249）,NT—proBNP出院前较术前升高,对照组升高显著（P=0．000）。组间比较NT—proBNP,对照组显著高于强化组（P=0．020）。住院期间两组患者无MACEs发生。首次急性前壁心肌梗死患者直接PCI后,强化阿托伐他汀治疗短期内可改善左心功能。     

急腹症2例误诊分析

急腹症是外科常见病和多发病,它是一种以急性腹痛为主要表现的临床急症,临床上常有误诊发生,最终造成严重后果。因而在诊疗过程中,必须对急性腹痛尽快作出定位、定性及病因诊断,以防误诊误治。现将我科收治的子宫穿孔误诊为消化道穿孔和输卵管卵巢脓肿误诊为阑尾周围脓肿的2例以急腹症表现为首发症状的患者在我科室的诊治过程及经验进行总结并进行分析,为临床能够提高急腹症的诊率断,降低误诊率提供借鉴,提高临床医生的鉴别能力,保证患者的身心健康。     

围手术期负荷剂量他汀对急性ST段抬高型心肌梗死患者预后的影响

为了探讨围手术期给予阿托伐他汀负荷剂量对急性ST段抬高型心肌梗死（STEMI）患者急诊经皮冠状动脉介入治疗（PCI）后对心血管事件的影响。选取因STEMI行急诊PCI术患者160例,其中80例于PCI术前给予阿托伐他汀负荷剂量40mg,80例术前未给予阿托伐他汀负荷剂量进行研究。分析两组患者住院期间肌酸激酶同工酶与超敏C反应蛋白值,PCI术后与术后1个月心功能情况。结果显示围手术期阿托伐他汀负荷剂量组主要心血管事件发生率优于非阿托伐他汀组（P〈0．05）。因此,围手术期给予负荷剂量的阿托伐他汀可以降低住院期间不良心血管事件的发生率,改善患者预后。     

我国酒精性肝病的医学困惑与应对策略

酒精性肝病是导致我国肝脏损害的第二大原因,已成为最严重的健康问题之一。我国已经迎来了酒精性肝病的高峰时期,并将会持续增长,卫生系统将面临巨大的压力。然而,对于酒精性肝病本身,还存在着诊断、治疗、预防等众多医学困惑;饮酒的危害不仅仅局限在肝脏,还可引起全身多器官的损害;酒害也早已超越了医疗界,是一个严重的社会问题。对于酒精性肝病的防治需要全社会共同参与,并且将是一条极其漫长而艰难的路程。     

Constant vigilance: Heritage values and defensive pessimism in coping with severe acute respiratory syndrome in Singapore

The present study investigates the congruency of defensive pessimism in the Asian context and its role in coping with the severe acute respiratory syndrome (SARS) crisis in Singapore. Data collected from 174 Singaporeans supported the hypothesized relationships among Chinese values, defensive pessimism, SARS-related fears, compliance to preventive health-related behaviors and negative outcomes. Path analysis revealed that individuals' endorsement of Chinese value clusters − prudence, industry, and civic harmony − positively predicted their levels of defensive pessimism. The results also indicated that defensive pessimism had a direct positive effect on SARS-related fears and, SARS-related fears, in turn, were directly related to direct preventive health-related behaviors but not related to indirect preventive behaviors. In addition to the indirect effect of Chinese values on direct preventive health-related behaviors, Chinese values had a direct positive effect on both direct and indirect preventive health-related behaviors. Consistent with our contention that defensive pessimism has the potential for leading to particular negative outcomes, defensive pessimism was found to influence negative outcomes but this relationship was partially mediated by SARS-related fears.     

Biases in the perceived prevalence and motives of severe acute respiratory syndrome prevention behaviors among Chinese high school students in Hong Kong

In two studies conducted in Hong Kong during and immediately after the outbreak of severe acute respiratory syndrome (SARS), participants displayed several social cognitive biases when they estimated the prevalence of and inferred the motives underlying SARS preventive behaviors. First, participants who practiced preventive behaviors (practicers) consistently estimated that more people practiced such behaviors than did non-practicers (false consensus bias). Second, for some preventive behaviors, participants believed that their own behaviors were more motivated by prosocial concerns (relative to self-interest) than were other practicers (pluralistic ignorance). Finally, non-practicers underestimated the importance of prosocial concerns underlying some preventive behaviors (actor-observer bias). We discussed the relevance of these social cognitive biases to health education and to Hong Kong people's psychological reactions to SARS.