帕金森病诊断标记物系统回顾与展望

本篇综述总结了帕金森病的诊断、鉴别诊断和病程监测的各领域的生物学标记物的研究进展。其中重点介绍了神经影像学和生物化学领域的生物学标记物,也是当前研究较为成熟的两大领域。神经影像学标记物以多巴胺能影像及非多巴胺能影像为代表,生物化学标记物为包括a一突触核蛋白在内的多种蛋白和激素,两者的结合能够有效提高疾病诊断的特异性和灵敏性。同时文章还介绍了当前研究的热点——帕金森病的前驱诊断手段,即在疾病典型的运动症状和非运动症状出现前便可预测帕金森病的诊断手段。     

19世纪帕金森病的研究历史

1817年Parkinson首先描述了震颤麻痹,此后的45年中陆续出现了一些相关报道,但并未增加有价值的临床信息。1861年以后,Charcot对此病进行了深入的研究,认识到动作缓慢是本病的核心症状之一,并将其与肌强直鉴别开。他细致地描述了面具脸等症状,认为震颤并非诊断的必要因素,在命名上建议用帕金森病来取代震颤麻痹。     

How Sensation Seeking provides a common basis for functional and dysfunctional outcomes

This research determines if Mastery Goal Orientation mediates Sensation Seeking in the prediction of functional performance and if Sensation Seeking directly predicts dysfunctional behavior. Using two different measures of Sensation Seeking, a sample of fulltime Australian workers was used to test the proposed learning mechanism in the prediction of supervisor rated work outcomes, self-reported work outcomes, and self-reported dysfunctional behavior. As predicted, mediation and suppression analyses provided strong support for the proposed model but with just one of the measures of Sensation Seeking. It is concluded that this mechanism of learning has much to offer our understanding of functional and dysfunctional outcomes.     

Modeling and estimating recall processing capacity: Sensitivity and diagnostic utility in application to mild cognitive impairment

We investigate the potential for using latency-based measures of retrieval processing capacity to assess changes in performance specific to individuals with mild cognitive impairment (MCI), a reliable precursor state to Alzheimer’s Disease. Use of these capacity measures is motivated in part by exploration of the effects of atrophy on a computational model of a basic hippocampal circuit. We use this model to suggest that capacity may be a more sensitive indicator of the underlying atrophy than speed of processing, and test this hypothesis by adapting a standard behavioral measure of memory (the free and cued selective reminding test, FCSRT) to allow for the collection of cued recall latencies. Participants were drawn from five groups: college-aged, middle-aged, healthy elderly, those with a diagnosis of MCI, and a sample of MCI control participants. The measure of capacity is shown to offer increased classificatory sensitivity relative to the standard behavioral measures, and is also shown to be the behavioral measure that correlated most strongly with hippocampal volume.     

百年郑玄易学研究的回顾与反思

1905至2010年间的郑玄易学研究经历了三个阶段,其中既有对传统经学研究路数的坚守,又有引入西学思想与方法的新实践,而现代学术制度、思想与方法最终成为郑易研究的主导,呈现出新旧学术交替的丰富性与复杂性,是中国传统学术现代化的缩影。西方学术的引入,客观上丰富了郑易研究的视角与途径,揭示、提升了郑易研究的多方面内容,其百年历程及特点也都显示出这一研究的新气象、新变化。然而,脱离传统经学理路的郑易研究,也存在着古今学术的"博通"与"精专"之争、古典与现代的学术理路的差异、经世面向的缺失等问题,无论是指导思想、学术方法与研究旨趣方面,还是在传统四部之学与现代学科理论实践的融合上均有值得反思之处,应予以深切关注和彻底省察。     

State mood,task performance,and behavior at work: A within-persons approach

We examine the intra-individual relationships between state mood and the primary components of the individual-level criterion space (task performance, organizational citizenship behavior, and work withdrawal) as they vary within the stream of work. Using experience-sampling methods, 67 individuals in a call center responded to surveys on palmtop computers at random intervals 4–5 times each day for 3 weeks (total N = 2329). These data were matched to objective task performance obtained from organizational call records (total N = 1191). Within-persons, periods of positive mood were associated with periods of improved task performance (as evidenced by shorter call time) and engaging in work withdrawal. Trait meta-mood moderated these relationships. Specifically, individuals who attended to their moods had a stronger relationship between mood and speed of task performance (call time) and individuals able to repair their mood cognitively evidenced a weaker relationship between mood and withdrawal. Implications and the use of within-persons designs are discussed.     

Advocacy,Political Participation,and Citizenship: Lutheran Contributions to Public Theology1

Abstract : Martin Luther never developed a political theory, but his theology does inform the way Christians live in society, making it both public and political. Luther's “two kingdom theory” often has been misinterpreted to justify passivity and obedience toward civil authorities. Under closer examination, however, his theology applies to the everyday practices of politics, economics, and religious affairs. In the context of nation‐building, a Lutheran theology fosters citizenship not only as individual rights and responsibilities, but as active participation in civil society.     

A memory-based model of Hick's law

We propose and evaluate a memory-based model of Hick’s law, the approximately linear increase in choice reaction time with the logarithm of set size (the number of stimulus–response alternatives). According to the model, Hick’s law reflects a combination of associative interference during retrieval from declarative memory and occasional savings for stimulus–response repetitions due to non-retrieval. Fits to existing data sets show that the model accounts for the basic set-size effect, changes in the set-size effect with practice, and stimulus–response-repetition effects that challenge the information-theoretic view of Hick’s law. We derive the model’s prediction of an interaction between set size, stimulus fan (the number of responses associated with a particular stimulus), and stimulus–response transition, which is subsequently tested and confirmed in two experiments. Collectively, the results support the core structure of the model and its explanation of Hick’s law in terms of basic memory effects.     

Memories defining the self in Alzheimer’s disease

ABSTRACT

There is a debate over the extent to which personal identity or the self is preserved in patients with Alzheimer’s disease (AD). Autobiographical memory deficits at early stages of AD could contribute to altering patients’ self. However, the nature of the relationship between autobiographical memory deficits and the self in AD has not been much investigated experimentally. In the present study, we aimed to investigate the integrative meaning of self-defining memories (SDMs) in early stages of AD and to analyse its relationship with the self-concept. The results showed that, when compared to the control group, AD patients less frequently extracted meaning from their SDMs and the meaning was less frequently tied to the self. Patients exhibited some altered aspects of the self-concept (i.e., complexity and strength), though some other components still persisted (i.e., valence and certainty). Correlation analyses showed that the impaired integrative meaning in the AD group was correlated with some changes in self-concept. We suggest that integrative meaning may act as a bridge between autobiographical memories and the self-concept, with reduced integration abilities appearing as a potential mechanism for the deterioration of the self-concept in AD.     

The orientation and temperature dependences of dislocation velocity in Ni 3 Al single crystals

The average velocities of screw dislocations in Ni 3 Al single crystals have been directly measured as a function of resolved shear stress (RSS) and orientation in the temperature domain of the flow stress anomaly using the etch-pit technique. The velocity was found to be extremely sensitive to the RSS in all cases. In contrast with ordinary metals, the screw dislocation velocities in Ni 3 Al show anomalous behaviour; under a constant RSS, the velocities decrease dramatically with increasing temperature. Furthermore, the velocities and the tension-compression asymmetry of the velocities depend on the orientation of applied stress.