The extent of working memory deficits associated with Williams syndrome: exploration of verbal and spatial domains and executively controlled processes

The present study investigated verbal and spatial working memory (WM) functioning in individuals with the neuro-developmental disorder Williams syndrome (WS) using WM component tasks. While there is strong evidence of WM impairments in WS, previous research has focused on short-term memory and has neglected assessment of executive components of WM. There is a particular lack of consensus concerning the profile of verbal WM functioning in WS. Here, WS participants were compared to typically developing participants matched for (1) verbal ability and (2) spatial ability (N = 14 in each of the 3 groups). Individuals with WS were impaired on verbal WM tasks, both those involving short-term maintenance of information and executive manipulation, in comparison to verbal-matched controls. Surprisingly, individuals with WS were not impaired on a spatial task assessing short-term maintenance of information in memory (remembering spatial locations) compared to spatial-matched controls. They were, however, impaired on a spatial executive WM task requiring the manipulation of spatial information in memory. The present study suggests that individuals with WS show WM impairments that extend to both verbal and spatial domains, although spatial deficits are selective to executive aspects of WM function.     

前瞻记忆的神经机制：来自临床研究的证据

前瞻记忆是指对预定事件或行为的记忆。本文总结了前瞻记忆脑机制相关的文献,介绍了前额皮层、丘脑,内侧颞叶等脑区域在前瞻记忆中的作用,并通过分析注意缺陷多动障碍儿童、老年痴呆症患者、酒精依赖症和内侧颞叶癫痫患者前瞻记忆的表现,从临床角度深入探讨了前瞻记忆神经机制的问题。证据表明,前额皮层参与前瞻记忆的编码、提取和监控过程,与意向保持也有密切的关系;丘脑与意向的执行有关,并且与前额叶互动在前瞻记忆监控中起着重要的作用;内侧颞叶与编码来源的提取和意向的激活都有密切的关系。研究认为前额皮层在前瞻记忆加工过程中起着核心的作用,同时与丘脑、内侧颞叶等区域相互作用,共同成为前瞻记忆编码、保持、提取、执行的神经基础。     

Perceptual grouping and distance estimates in typical and atypical development: comparing performance across perception, drawing and construction tasks

Perceptual grouping is a pre-attentive process which serves to group local elements into global wholes, based on shared properties. One effect of perceptual grouping is to distort the ability to estimate the distance between two elements. In this study, biases in distance estimates, caused by four types of perceptual grouping, were measured across three tasks, a perception, a drawing and a construction task in both typical development (TD: Experiment 1) and in individuals with Williams syndrome (WS: Experiment 2). In Experiment 1, perceptual grouping distorted distance estimates across all three tasks. Interestingly, the effect of grouping by luminance was in the opposite direction to the effects of the remaining grouping types. We relate this to differences in the ability to inhibit perceptual grouping effects on distance estimates. Additive distorting influences were also observed in the drawing and the construction task, which are explained in terms of the points of reference employed in each task. Experiment 2 demonstrated that the above distortion effects are also observed in WS. Given the known deficit in the ability to use perceptual grouping in WS, this suggests a dissociation between the pre-attentive influence of and the attentive deployment of perceptual grouping in WS. The typical distortion in relation to drawing and construction points towards the presence of some typical location coding strategies in WS. The performance of the WS group differed from the TD participants on two counts. First, the pattern of overall distance estimates (averaged across interior and exterior distances) across the four perceptual grouping types, differed between groups. Second, the distorting influence of perceptual grouping was strongest for grouping by shape similarity in WS, which contrasts to a strength in grouping by proximity observed in the TD participants.     

Immortality and boredom: a response to Wisnewski

This article contributes to the ongoing debate initiated by Bernard Williams’ claim that, due to the non-contingent finitude of the categorical desires that give meaning to our lives, an immortal life would necessarily become intolerably boring. Jeremy Wisnewski has argued that even if immortality involves periods in which our categorical desires have been exhausted, this need not divest life of meaning since some categorical desires are revivable. I argue that careful reflection upon the thought-experiments adduced by Wisnewski reveals that they do not substantiate his proposal, and hence that a plausible reason for rejecting Williams’ position has not been provided.     

Why neuroscience matters to cognitive neuropsychology

The broad issue in this paper is the relationship between cognitive psychology and neuroscience. That issue arises particularly sharply for cognitive neurospsychology, some of whose practitioners claim a methodological autonomy for their discipline. They hold that behavioural data from neuropsychological impairments are sufficient to justify assumptions about the underlying modular structure of human cognitive architecture, as well as to make inferences about its various components. But this claim to methodological autonomy can be challenged on both philosophical and empirical grounds. A priori considerations about (cognitive) multiple realisability challenge the thesis on philosophical grounds, and neuroscientific findings from developmental disorders substantiate that challenge empirically. The conclusion is that behavioural evidence alone is inadequate for scientific progress since appearances of modularity can be thoroughly deceptive, obscuring both the dynamic processes of neural development and the endstate network architecture of real cognitive systems.     

Creativity, “Twinning,” and Self-Destruction in the Life and Work of Tennessee Williams

Applying an eclectic psychoanalytic framework, this paper provides a thematic link between the core experiences of Williams' early life and his creative work. Both preoedipal and Oedipal themes are elucidated. The central issue that dominated Williams' mental life was his struggle between a sense of suffocation and confinement, on the one hand, and having artistic and sexual freedom, on the other. The experience of suffocation extended to his dread of becoming mad. This dread derived from his intense twinning or twinship merger with his schizophrenic sister who was confined in an asylum. The study focuses attention on a number of Williams' one-act and full-length plays, written during each of the decades of his public career, as representative of his overall dramatic opus. These works are indicative of his special relationship with his sister as well as of his obsession about self-indulgence and fear of confinement. The later plays suggest that he was subject to identity confusion.     

TV cameras,public self-consciousness,and mock juror performance

In Chandler v. Florida (1981), the U.S. Supreme Court ruled that the presence of television cameras in the courtroom does not violate a defendant's constitutional right to a fair trial. Since then, several states have expanded their TV coverage rights, and the controversy has intensified. The present study tested opponents' argument that TV cameras distract jurors, thereby reducing their reliance on evidence in the decision-making process. Fifty-one community adults watched a 95-min videotape of a civil trial in the presence or absence of a camera. No effects were obtained on verdicts, awards, or a series of self-report measures. The camera did impair subjects' recall of the evidence, but this effect was dually limited—(a) consistent with an adaptation hypothesis, an initially strong distractive effect gradually diminished, resulting in a net post-trial loss of information that was not statistically significant, and (b) consistent with an individual differences hypothesis, the camera impaired the recall of subjects who were low but not high in dispositional public self-consciousness. These findings were discussed in terms of their practical implications for courtroom management and their contribution to the self-awareness literature.     

Evidence for a developmental shift in the basis for memory organization

Using a false recognition procedure, either with or without instructions to facilitate Synonym or Antonym encoding, 128 second- and sixth-grade boys and girls were tested. The results indicated that there were no grade or sex differences in generalization errors to synonyms or antonyms under neurtral learning instructions, but that facilitative instructions interacted with grade level. Under instructions to facilitate synonym encoding, second graders showed a marked increase in synonym errors. On the other hand, under instructions to facilitate antonym encoding, sixth graders showed an increase in antonym errors. In addition, association strength was directly related to the magnitude of the generalization errors in both grades. The results are discussed in terms of age-related shifts in the basis underlying the organization of verbal memories.     

The perception of consistency in attitudes

A study was conducted to test the hypothesis that when people change their attitudes they reduce the dissonance associated with the inconsistency of their new and previous positions by distorting their recall of their initial stand to make it consistent with their new attitude. Small groups of high school students discussed bussing, one of 30 pretested issues. An experimental confederate participated in each session with the task of effecting attitude change. After the discussion, the subjects' new attitudes were assessed and they were asked to duplicate their pretest scores. The results confirmed the hypothesis. Subjects distorted their recall of their initial stand on bussing so as to make it consistent with their new attitude. Such distortion allows persons to feel that their new position is the one they have always held. The subjects made such recall errors only on the bussing issue. Control subjects did not distort their original bussing attitudes.     

Children's understanding of sentences with contingent relations: Why are temporal and conditional connectives so difficult?

Children aged 5-, 7-, and 9 were tested on two different tasks to assess their understanding of sentences containing the connectives “when,” “as soon as,” “before,” “after,” “if,” “if-not,” “unless,” and “unless-not.” The results revealed significant improvement between the ages of 5 and 7. This improvement was attributed, in part, to an increased ability to retain information expressed in subordinate clauses. At all age levels, however, the connectives “unless” and “unless-not” were consistently misinterpreted; “unless” was treated as its polar opposite “if,” and “unless-not” was treated as its polar opposite “if-not.”