Competing interests: The need to control conflict of interests in biomedical research

Individual and institutional conflict of interests in biomedical research have becomes matters of increasing concern in recent years. In the United States, the growth in relationships — sponsored research agreements, consultancies, memberships on boards, licensing agreements, and equity ownership — between for-profit corporations and research universities and their scientists has made the problem of conflicts, particularly financial conflicts, more acute. Conflicts can interfere with or compromise important principles and obligations of researchers and their institutions, e.g., adherence to accepted research norms, duty of care to patients, and open exchange of information. Disclosure is a key component of a successful conflict policy. Commitments which conflict with a faculty member's primary obligations to teaching, research, administrative responsibilities, or patient care also need attention. Institutional conflict of interests present different problems, some of which are discussed in an analysis of an actual problem posed by two proposed clinical trials. This paper is adapted from a lecture presented to a Symposium on Scientific Integrity, Warsaw, Poland, 23 November 1995. Daniel Steiner was Vice-President and General Counsel of Harvard University (1972–92) and in that capacity became familiar with conflict of interest issues. He is currently Counsel to the Boston law firm. Ropes and Gray, and is Adjunct Lecturer in Public Policy at the John F. Kennedy School of Government. Harvard University.     

A new measure for determining children's subjective organization of speech

A new technique for determining children's subjective organization of speech is described. The technique consists of teaching a child a sentence and then repeatedly (1) reading the sentence up to a selected point, (2) sounding a tone, and (3) having the child supply the next word. The time from the tone to the onset of the child's voice is the dependent variable. In the first study 6- and 8-year-old children memorized the following sentence: “John likes to feed the little puppies in the barn.” Their response times suggested that the dominant segmentation pattern consisted of four phrases: a subject phrase, a verb phrase, an object phrase and a modifier phrase. Within each phrase differences between reaction times were on the order of 30 msec. Across phrases they were on the order of 120 msec. The same trend emerged for subsamples of the children with various short-term memory sizes, and for adults. It also appeared for subsamples of the total scores (e.g., first six trials and last six trials). In order to provide further evidence of the technique's validity, different sentences of the same general type were presented to children with short-term memory spans of either 3, 4, or 5. As predicted, it was found that when children's spans corresponded to the number of hypothesized chunks (i.e., 4), they could repeat the sentences verbatim on the first exposure. They could not do so, however, when their spans were lower than that value or when the number of phrases was increased. It was concluded that the new technique is a promising one for assessing young children's patterns of speech segmentation.     

Effects of neutral and positive stimuli on stuttering: “Calling attention to stuttering” revisited

This study investigated the effects of presumably positive and neutral response-contingent stimuli on the occurence of stuttering. Eight adult stutterers spoke spontaneously during a 60-min experimental session, which was divided into three 20-min periods. During Condition I no stimuli were delivered. During Condition II a digital counter and a pair of yellow lights were activated each time the subject stuttered. During Condition III these same response-contingent stimuli were delivered, but with the additional factor that the subject would earn 5¢ each time the counter moved forward and the lights were illuminated. Conditions II and III were counterbalanced across subjects. The experimenter was unaware of which of the two contingencies were operative during Conditions II and III. Results showed no significant changes in occurence of stuttering due to either response-contingent stimulus. A discussion of theoretical and experimental implications is given.     

The use of averaged electroencephalic response techniques in the study of auditory processing related to speech and language

This paper reviews a number of studies done by the authors and others, who have utilized various averaged electroencephalic response (AER) techniques to study speech and language processing. Pertinent studies are described in detail. A relatively new AER technique, auditory brainstem responses (ABR), is described and its usefulness in studying auditory processing activity related to speech and language is outlined. In addition, a series of ABR studies, that have demonstrated significant male—female differences in ABR auditory processing abilities, is presented and the relevance of these data to already established differences in male—female language, hearing, and cognitive abilities is discussed.     

Are there constraints on childhood disfluency?

Analysis of the spontaneous speech of eight stuttering and eight normally fluent children reveals that (a) the location of both stuttering and normal disfluent moments is constrained by sentential constituent structure, and (b) stuttering children experience fluency breakdown with a particular type of constituent (verb phrase) not usually disfluently produced by normals. A view of early stuttering as a sentence planning and integration disorder is present.     

Stuttering and fluency: Exclusive events or points on a continuum?

In recent years, several studies have been conducted in which the fluency of stutterers was compared with that of normal speakers. These investigations have been of two basic types, some involving objective measures of physiologic, aerodynamic, or acoustic features of the subjects' fluent speech signal, and others involving experiments performed in which listeners attempted to distinguish the fluency produced by stutterers from that generated by normal speakers. The body of literature pertaining to each of these two types of investigations is reviewed and interpreted. The interpretations offered are then developed in an effort to shed further light on both fluency and stuttering. Implications for further research, as well as for the evaluation, treatment, and post-therapy assessment of stutterers are drawn.     

Concurrent validity of the WISC-R factor scores

This study investigated the efficacy of predicting academic achievement as measured by the Wide Range Achievement Test using the factor scores of the Wechsler Intelligence Scale for Children-Revised as potential predictors. Both instruments were administered to 200 school children referred for psychological evaluations. Factor scores for the WISC-R were computed according to equations provided by Gutkin (1978). These factor scores then were regressed in a stepwise manner on the Reading, Spelling, and Arithmetic standard scores from the Wide Range Achievement Test. Stepwise regressions also were performed using the traditional Verbal and Performance IQs as the potential predictors. A comparison was made between the results obtained by use of the factors or the more common scores. The results indicated that the Freedom From Distractibility factor score significantly aided in the prediction of Reading and Spelling achievement and was of primary importance in predicting Arithmetic achievement. When the stepwise results using the different scores were contrasted, the factor scores accounted for appreaciably more variance in Arithmetic than did the traditional Verbal and Performance IQs. Derived regression equations are reported along with a discussion of the interpretability of the Freedom From Distractibility factor.     

Beliefs about beliefs: representation and constraining function of wrong beliefs in young children's understanding of deception

Understanding of another person's wrong belief requires explicit representation of the wrongness of this person's belief in relation to one's own knowledge. Three to nine year old children's understanding of two sketches was tested. In each sketch subjects observed how a protagonist put an object into a location x and then witnessed that in the absence of the protagonist the object was transferred from x to location y. Since this transfer came as a surprise they had to assume that the protagonist still believed that the object was in x. Subjects had to indicate where the protagonist will look for the object at his return. None of the 3–4-year old, 57% of 4–6-year old, and 86% of 6–9-year old children pointed correctly to location x in both sketches. Of the many cases where 4–6-year olds made an error they failed in only about 20% to remember the initial location correctly. As a test of the stability of children's representation of the protagonist's wrong belief the sketches continued with a statement about the protagonist's intention to either deceive an antagonist or truthfully inform a friend about the object's location. Independent of age, of those children who correctly thought that the protagonist would search in x, 85% of the time they also correctly thought that he would direct his antagonist to location y and his friend to location x. This shows that once children can represent a person's beliefs they can constrain their interpretation of this person's stated intentions to the person's beliefs. In a more story-like situation another group of children had to infer a deceptive plan from the depiction of a goal conflict between two story characters and one character's expedient utterance. At the age of 4–5 years children correctly judged this utterance as a lie only 28% of the time while 5–6-year olds did so 94% of the time. These results suggest that around the ages of 4 to 6 years the ability to represent the relationship between two or more person's epistemic states emerges and becomes firmly established.     

A procedural theory of eye movements in doing arithmetic

A procedural theory of eye movement that accounts for main features of the stochastic behavior of eye-fixation durations and direction of movement of saccades in the process of solving arithmetic exercises of addition and subtraction is presented. The best-fitting distribution of fixation durations with a relatively simple theoretical justification consists of a mixture of an exponential distribution and the convolution of two exponential distributions. The eye movements themselves were found to approximate a random walk that fits rather closely in both adult and juvenile subjects the motion postulated by the normative algorithm ordinarily taught in schools. Certain structural features of addition and subtraction exercises, such as the number of columns, the presence or absence of a carry or a borrow, are well known to affect their difficulty. In this study, regressions on such structural variables were found to account for only a relatively small part of the variation in eye-fixation durations.