进展期非小细胞肺癌维持治疗进展

化疗在进展期非小细胞肺癌的地位已经确立,现有的方案已经达到“化疗疗效平台”。延长化疗无潜在益处,有什么办法可以保持现有的疗效。为此,提出了维持治疗的概念,维持治疗是指患者在完成标准的几个周期化疗且疾病得到控制后再接受的化疗,架起一二线治疗间的桥梁。带来进一步的临床获益。     

Great apes’ performance in discriminating weight and achromatic color

Much work has been done on visual discrimination in primates over the past decade. In contrast, very little is known about the relevance of non-visual information in discrimination learning. We investigated weight and achromatic color (color, henceforth) discrimination in bonobos, gorillas and orangutans, using the exchange paradigm in which subjects have to give objects to the experimenter in order to receive a reward. Unlike previous studies, subjects were not trained to lift objects because lifting the objects was an integral part of the exchange procedure. This methodology also allowed us a direct comparison between visual and weight discrimination. We presented 12 subjects (5 bonobos, 2 gorillas and 5 orangutans) with two sets of objects corresponding to two conditions. The objects in the color condition (white/black) differed only in color and those in the weight condition (light/heavy) differed only in weight. Five apes learned to discriminate weight and six to discriminate color. Subjects learned color discrimination faster than weight discrimination. Our results suggest that bonobos and orangutans are sensitive to differences in weight and able to learn discriminating objects that differ in this property.     

行为经济学中的损失规避

损失规避是指,人们总是强烈倾向于规避损失：一定数额的损失所引起的心理感受,其强烈程度约相当于两倍数额的获益感受。这种强烈的心理与行为倾向广泛存在于风险与非风险领域,在该两个领域中损失规避的研究范式也不同。损失规避常见于经济和消费等领域,可用于解释行为决策中有悖于规范化理论的诸多现象,如禀赋效应、现状偏差、股权溢价之迷和赢者的诅咒等。然而,损失规避的机制研究还存在许多尚未解决的问题,如损失规避的本质以及适用条件。今后的研究不仅要注重认知角度和情感依恋,还要结合认知过程来研究损失规避的性质和内在机制,以期帮助人们认识、预测及干预由损失规避造成的经济损失和非理性决策。     

Employability during unemployment: Adaptability, career identity and human and social capital

Recently, Fugate et al. [Fugate, M., Kinicki, A. J., & Ashforth, B. E. (2004). Employability: A psycho-social construct, its dimensions, and applications. Journal of Vocational Behavior, 65(1), 14] defined employability as a psycho-social construct comprised of three dimensions: (i) adaptability; (ii) career identity; and (iii) human and social capital. The aim of the current paper was to empirically test Fugate et al.’s model in a sample of 416 unemployed Australians (n = 126 for longitudinal sample). Specifically, this research explored employability in relation to three aspects of unemployment: (1) self-esteem during unemployment; (2) job search during unemployment; and (3) re-employment (at a 6-month follow-up). Overall, the results of this longitudinal study provide broad support for the psycho-social construct of employability and demonstrate its applicability to the unemployment context.     

Working through the end of civilization

This is an account of how a civilization works through the problems it faces when it is threatened with destruction. It focuses on the example of the Crow Nation, an Indian tribe of the northwest plains of North America, and their last great chief Plenty Coups. Psychoanalytic ideas play a crucial role in explaining how a creative response was possible. In particular, their collective use of dream-visions and dream-interpretation made possible the creation of a new ego ideal for the tribe. This allowed for the transformation of traditional allocations of shame and humiliation. It also allowed for the possibility of transformation of psychological structure. And it opened up new possibilities for what might count as flourishing as a Crow. Conversely, the threat of civilizational collapse allows us to see new possibilities for the conceptual development of psychoanalysis. In particular, psychoanalysis needs to recognize that destruction can occur at the level of the culture while the individuals are not physically harmed. The psychological states of these individuals can be various and complex and cannot be neatly summed up under the category of trauma. A culture can be devastated, while there is no one-to-one relation to the psychological states of the individuals who participate in that culture. It is also true that a collapse of a way of life makes a variety of psychological states impossible. Coming to understand these phenomena is essential to understanding how a culture works through threats to its very existence.     

The return of the erased: Memory and forgetfulness in Eternal sunshine of the spotless mind (2004)

Eternal sunshine of the spotless mind is a film about remembering and forgetting loss. This essay reads the film as an examination of mourning and melancholia, which are distinct ways of remembering and forgetting both a love object and its loss. Freud distinguished mourning from its pathological counterpart, melancholia, claiming that there is a normal way to grieve, mourning, and its degeneration into an abnormal pattern, melancholia. The author aims to make two points: firstly, that both processes are characterized by ambivalence and identification and therefore have some commonalities; secondly, that there is a difference between the two processes that is less apparent than the ones discussed by Freud. This is the difference between remembering a good and a bad object. Following Klein the author argues that this is a crucial qualitative difference between mourning and melancholia. She concludes that a central issue in grieving is not forgetting but remembering well.     

Composition of brain oscillations and their functions in the maintenance of auditory,visual and audio–visual speech percepts: an exploratory study

In the present exploratory study based on 7 subjects, we examined the composition of magnetoencephalographic (MEG) brain oscillations induced by the presentation of an auditory, visual, and audio-visual stimulus (a talking face) using an oddball paradigm. The composition of brain oscillations were assessed here by analyzing the probability-classification of short-term MEG spectral patterns. The probability index for particular brain oscillations being elicited was dependent on the type and the modality of the sensory percept. The maintenance of the integrated audio-visual percept was accompanied by the unique composition of distributed brain oscillations typical of auditory and visual modality, and the contribution of brain oscillations characteristic for visual modality was dominant. Oscillations around 20 Hz were characteristic for the maintenance of integrated audio-visual percept. Identifying the actual composition of brain oscillations allowed us (1) to distinguish two subjectively/consciously identical mental percepts, and (2) to characterize the types of brain functions involved in the maintenance of the multi-sensory percept.     

The phenomenology of agency and intention in the face of paralysis and insentience

Studies of perception have focussed on sensation, though more recently the perception of action has, once more, become the subject of investigation. These studies have looked at acute experimental situations. The present paper discusses the subjective experience of those with either clinical syndromes of loss of movement or sensation (spinal cord injury, sensory neuronopathy syndrome or motor stroke), or with experimental paralysis or sensory loss. The differing phenomenology of these is explored and their effects on intention and agency discussed. It is shown that sensory loss can have effects on the focussing of motor command and that for some a sense of agency can return despite paralysis.

Investigation of ethnic differences in body image between Hispanic/biethnic-Hispanic and non-Hispanic White preadolescent girls

The extent to which the construct of body image is measurement invariant across ethnic groups is an important consideration for studies examining ethnic differences and characteristics that influence body image disturbances. However, the literature examining the body image construct as a function of ethnic group membership is limited. The primary aim of this study was to investigate whether Hispanic/biethnic-Hispanic and non-Hispanic White preadolescent girls (aged 8 through 12 years old; N = 141) had fundamentally different conceptualizations of body image in a low to low/middle socioeconomic status school-based sample. Our findings suggest that the measurement construct of body image was similar and relatively stable for Hispanic/biethnic-Hispanic and non-Hispanic White preadolescent girls. In addition, the body image construct was predictably related to disordered eating symptoms in both groups, with different dimensions of body image differentially predictive by ethnic group. Overall, body image appears to be a meaningful construct with similar measurement meanings across Hispanic/biethnic-Hispanic and non-Hispanic White ethnic groups.     

影响说谎行为的情境因素——基于自我概念维持理论的视角

情境因素会影响人们的说谎行为。本文基于自我概念维持理论的视角,从个体内部状态（自我控制资源、宗教表征/道德观念启动）和外部因素（金钱奖励、人际因素）两方面介绍情境因素对说谎行为的影响,并指出未来研究应关注自我觉察水平这一情境因素以及情境因素影响说谎行为的心理机制和神经机制。