Education and testing strategy for large-scale cystic fibrosis carrier screening

Population-based screening for cystic fibrosis carrier mutations presents a number of challenges for genetic counselors, owing primarily to the inability of current DNA testing technology to identify all possible mutations and the difficulty involved in conveying the concept of residual risk to those patients who test negative. To address these issues, we are conducting a pilot study, as part of a consortium established by the National Center for Human Genome Research, to explore the efficacy, acceptance, and psychosocial impact of various approaches to carrier screening in an ethnically diverse Southern California population. This article reports the patient instructional and screening strategies we developed in the initial phase of the project in order to optimize our chances of answering these questions and delivering this service on a large scale.     

Infants' fast saccades in the gap paradigm and development of visual attention

The saccadic reaction times (SRTs) in the overlap, no-overlap, and gap conditions of 2.5- to 12-month-old infants and adults were measured. In the overlap condition, the SRTs of younger infants were over 600 ms longer than those of older infants, whereas the SRTs in the gap condition of the younger infants were 300–350 ms, much faster than reported hitherto, and were shortened only by about 100 ms. The results indicate that the oculo-motor system and attention process for disengagement in the gap condition mature earlier than the attention process for disengagement in the overlap condition.     

The local organization of behavior: dissociations between a pigeon's behavior and self-reports of that behavior

The purpose of the experiment was to study the relation between what an organism does in a setting that demands temporal patterning of behavior and what it reports it has done. More specifically, a pigeon produced two classes, shorter and longer, of temporal patterns of key pecks (interresponse times) on a center key. Occasionally, a symbolic matching-to-sample probe arranged on side keys asked the pigeon whether its most recent pattern was a shorter or longer one. The longer reinforced pattern was always three times as long as the shorter one and the two patterns were reinforced equally often. Absolute duration of reinforced patterns was varied. In some conditions, interresponse-time distributions on the center key were bimodal, indicating a clear behavioral adaptation to the contingency, yet a bird did not report very well by appropriate side-key responding what its most recent interresponse time had been. In other conditions, the interresponse-time distributions were less clearly bimodal, yet a bird reported more accurately its previous interresponse time as shorter or longer. Thus, there was a dissociation between how well behavior on the center key conformed to the schedule requirement and how well a bird reported what it was doing on the center key. In addition, as absolute duration of the reinforced patterns was increased, a bird categorized its most recent pattern less well even as its preference for the shorter pattern increased dramatically. These results were interpreted as an example of the phenomenon of dissociation between tacit knowledge and knowledge.     

Combinations of Tense and Modality for Predicate Logic

In recent years combinations of tense and modality have moved into the focus of logical research. From a philosophical point of view, logical systems combining tense and modality are of interest because these logics have a wide field of application in original philosophical issues, for example in the theory of causation, of action, etc. But until now only methods yielding completeness results for propositional languages have been developed. In view of philosophical applications, analogous results with respect to languages of predicate logic are desirable, and in this paper I present two such results. The main developments in this area can be split into two directions, differing in the question whether the ordering of time is world-independent or not. Semantically, this difference appears in the discussion whether T×W-frames or Kamp-frames (resp. Ockham-frames) provide a suitable semantics for combinations of tense and modality. Here, two calculi are presented, the first adequate with respect to Kamp-semantics, the second to T×W-semantics. (Both calculi contain an appropriate version of Gabbay's irreflexivity rule.) Furthermore, the proposed constructions of canonical frames simplify some of those which have hitherto been discussed.     

Most family physicians report communicating the risks of adverse drug reactions in words (vs. numbers)

Family physicians can communicate to patients the risk of adverse drug reactions using words or numbers, and this format has important implications for patients' ability to make informed decisions. The present study (a) assessed which formats family physicians preferred to communicate the risk of a given side effect, (b) tested whether the severity of this adverse drug reaction affected this preference, and (c) investigated the type of quantifiers physicians preferred to use in general (e.g., ratios, percentages). In a format selection task, a sample of 131 family physicians reported that they mostly use words to communicate to patients the risk of mild and severe adverse drug reactions, but the verbal preference was weaker for severe adverse drug reactions. The quantifier selection task showed that the most common quantifiers were verbal frequencies and verbal probabilities. Family physicians and patients should be aware of the implications of this preference.     

Fringe consciousness in sequence learning: the influence of individual differences

We first describe how the concept of “fringe consciousness” ([Mangan, 1993a], [Mangan, 1993b], [Mangan, 2001] and [Mangan, 2003]) can characterise gradations of consciousness between the extremes of implicit and explicit learning. We then show that the NEO-PI-R personality measure of openness to feelings, chosen to reflect the ability to introspect on fringe feelings, influences both learning and awareness in the serial reaction time (SRT) task under conditions that have previously been associated with implicit learning ([Destrebecqz and Cleeremans, 2001] and [Destrebecqz and Cleeremans, 2003]). This provides empirical evidence for the proposed phenomenology and functional role of fringe consciousness in so-called implicit learning paradigms (Mangan, 1993b). Introducing an individual difference variable also helped to identify possible limitations of the exclusion task as a measure of conscious sequence knowledge. Further exploration of individual differences in fringe awareness may help to avoid polarity in the implicit learning debate, and to resolve apparent inconsistencies between previous SRT studies.     

The influence of complexes on implicit learning

A century ago, Jung looked into the unconscious through complexes by using word association tests. Jung wrote, 'modern psychology with its investigation of complexes has opened up a psychic taboo area riddled with hopes and fears', and complexes remain an unexplored taboo area of research. In the present study, we have investigated the influence of complexes on unconscious cognitive processing, in particular on implicit learning. We have found that complexes shown to disturb conscious cognitive processing in fact enhanced the attention of the subjects and their performance on an implicit learning task. These results suggest that complexes are not just abstractions, but have various actual influences on both conscious and unconscious processing.     

The vocal dialogue in 9/11 pregnant widows and their infants: Specificities of co-regulation

Mothers who were pregnant and widowed on September 11, 2001, and their 4–6-month infants (in utero on 9/11) were filmed during face-to-face interaction and their vocal dialogues were examined via microanalysis. Mothers were White, well-educated, mean age 34.3 years, and far from the World Trade Center site on 9/11; infants were 4–6 months, half female. We examined the bi-directional, moment-by-moment co-regulation of the timing of vocal dialogue, and particularly turn taking, in mother-infant and stranger-infant interactions, with time-series models. We analyzed the contingent coordination of durations of (1) vocalizations of the turn-holder, and (2) switching-pauses at the moment of the turn exchange. The switching pause is an aspect of the rhythm of the turn-holder who, after taking a turn, yields the floor to the partner through the switching pause. Turn taking is the lynchpin of dialogue, and the bi-directional contingent coordination of the switching-pause regulates the turn exchange. Both partners showed signs of risk and resilience. The 9/11 mothers did not coordinate the timing of turn taking with their infants, a highly unusual finding. In contrast, the 9/11 infants did coordinate the timing of turn taking with their mothers, and with the “stranger,” forms of resilience. We propose that the 9/11 mother’s difficulty coordinating with the infant’s turn taking rhythm is a mode of transmission of her trauma to the infant. This work expands our knowledge of the specificities of co-regulation in the context of the 9/11 trauma.     

Response to Donald Kalsched

I have attempted to focus this discussion by looking at three interrelated matters. There is the issue of Sue's final dream – the enigma with which Don Kalsched leaves us. I first have a go at that, from my own, as well as some other, perspectives. Then, there is the question central to this presentation of the archetypal defense itself. What, in fact, arethese defenses, and how is the author using the concept of the ‘archetypal’? Finally, I wouldn't be me if I didn't rise to the bait of Sue's shame, more prevalently peppered throughout the first draft than the present one.     

Mental rotation and temporal contingencies.

A task that requires subjects to determine whether two forms of the same shape, but in different orientations, are mirror images or identical except for orientation is called a handedness recognition task. Subjects' reaction times (RT) on this task are consistently related to the angular disparity (termed alpha) between the two presented forms. This pattern of data has been interpreted to indicate that subjects solve the task by imagining that one of the forms rotates into the orientation of the other (termed mental rotation). The speed with which one imagines one of the forms rotating has been widely considered a fixed capability of the individual, and thus immune to the effect of contingencies. We present an experiment that assesses the effects of temporal contingencies in a handedness recognition task on the slope of the function RT = f(alpha). The data indicate that the slope of this function can come under the control of temporal contingencies.