Effects of rodent prefrontal lesions on object-based, visual scene memory

It has been suggested that certain prefrontal areas contribute to a neural circuit that mediates visual object memory. Using a successive go/no-go visual scene discrimination task, object-based long-term memory was assessed in two rodent prefrontal regions. Rewarded trials consisted of a standard scene of four toy objects placed over baited food wells. The objects and their locations composing the standard scene remained constant for the duration of the study. Trials in which one of the standard scene objects was replaced with a novel object were not rewarded. Following the establishment of a significant difference between latency to approach the rewarded standard scene compared to latency to approach non-rewarded scenes, quinolinic acid or control vehicle was infused into either the prelimbic and infralimbic cortices or the anterior cingulate cortex. Following a 1 week recovery period, subjects were retested. Animals with prelimbic/infralimbic cortex lesions displayed a profound and sustained deficit, whereas, animals with anterior cingulate cortex lesions showed a slight initial impairment but eventually recovered. Both lesion groups acquired a simple single object discrimination task as quickly as controls indicating that the deficits on the original scene discrimination task were not due to motivational, response inhibition, or perceptual problems.     

Attention and the multiple stages of multisensory integration: A review of audiovisual studies

Multisensory integration and crossmodal attention have a large impact on how we perceive the world. Therefore, it is important to know under what circumstances these processes take place and how they affect our performance. So far, no consensus has been reached on whether multisensory integration and crossmodal attention operate independently and whether they represent truly automatic processes. This review describes the constraints under which multisensory integration and crossmodal attention occur and in what brain areas these processes take place. Some studies suggest that multisensory integration and crossmodal attention take place in higher heteromodal brain areas, while others show the involvement of early sensory specific areas. Additionally, the current literature suggests that multisensory integration and attention interact depending on what processing level integration takes place. To shed light on this issue, different frameworks regarding the level at which multisensory interactions takes place are discussed. Finally, this review focuses on the question whether audiovisual interactions and crossmodal attention in particular are automatic processes. Recent studies suggest that this is not always the case. Overall, this review provides evidence for a parallel processing framework suggesting that both multisensory integration and attentional processes take place and can interact at multiple stages in the brain.     

Impulse processing: a dynamical systems model of incremental eye movements in the visual world paradigm

The Visual World Paradigm (VWP) presents listeners with a challenging problem: They must integrate two disparate signals, the spoken language and the visual context, in support of action (e.g., complex movements of the eyes across a scene). We present Impulse Processing, a dynamical systems approach to incremental eye movements in the visual world that suggests a framework for integrating language, vision, and action generally. Our approach assumes that impulses driven by the language and the visual context impinge minutely on a dynamical landscape of attractors corresponding to the potential eye-movement behaviors of the system. We test three unique predictions of our approach in an empirical study in the VWP, and describe an implementation in an artificial neural network. We discuss the Impulse Processing framework in relation to other models of the VWP.     

An anxiety-induced bias in the perception of a bistable point-light walker

Human sensitivity for social cues is exquisite, as illustrated by the ease with which simplified point-light movements invoke social and emotional responses. Compared to faces, these biological motion stimuli only recently started to be used to explore questions regarding social cognition and anxiety. We presented human point-light walkers that could be perceived as facing towards or facing away from the observer, and tested whether participants with high social anxiety would perceive these bistable stimuli differently, because this type of stimuli has particular relevance for them. The results showed that observers with high social anxiety tended to see walkers as facing away more frequently than those with low social anxiety. This may mean that high socially anxious observers are biased towards the more positive perceptual alternative because they are motivated to protect themselves against threatening social experiences, but we also explore alternative explanations. The findings are in line with the evidence for a positivity bias in perception, also called wishful seeing, but in contrast with the attentional negativity bias often found in social anxiety. We discuss reasons for this divergence and possible limitations of the current study.     

The role of the human extrastriate visual cortex in mirror symmetry discrimination: a TMS-adaptation study

The human visual system is able to efficiently extract symmetry information from the visual environment. Prior neuroimaging evidence has revealed symmetry-preferring neuronal representations in the dorsolateral extrastriate visual cortex; the objective of the present study was to investigate the necessity of these representations in symmetry discrimination. This was accomplished by the use of state-dependent transcranial magnetic stimulation, which combines the fine resolution of adaptation paradigms with the assessment of causality. Subjects were presented with adapters and targets consisting of dot configurations that could be symmetric along either the vertical or horizontal axis (or they could be non-symmetric), and they were asked to perform a symmetry discrimination task on the targets while fixating the center of the screen. TMS was applied during the delay between the adapter and the test stimulus over one of four different sites: Left or Right V1/V2, or left or right dorsolateral extrastriate cortex (DLO). TMS over both Left and Right DLO reduced the adaptation effect in detecting vertical and horizontal symmetry, although the Left DLO effect on horizontal symmetry and the Right DLO effect on both vertical and horizontal symmetry were present only when considering subjects who showed a behavioral adaptation effect in the baseline No-TMS condition. Application of TMS over the Left or Right V1/V2 did not modulate the adaptation effect. Overall, these data suggest that both the Left and Right DLO contain neuronal representations tuned to mirror symmetry which play a causal role in symmetry discrimination.     

Does degree of asymmetry relate to performance? A reply to Boles and Barth

In a recent critique Boles and Barth (2011) argue that their prior study investigating asymmetry/performance relationships (Boles, Barth, & Merrill, 2008) uncovered the “true” association (i.e., negative correlation) between lateralization of visual lexical processes and word recognition performance. They contend that our study reporting positive correlations of lexical asymmetry and reading performance (Chiarello et al., 2009) was flawed and hence inconclusive. In this response we address the two major objections raised by Boles and Barth (2011) regarding our selection of tasks and asymmetry measures. We conclude that the Boles and Barth principle of task purity is not relevant to the stated aims of our investigation, and that our linear regression method of measuring asymmetry is valid given the high level of accuracy for the tasks we reported. Because the aims of each investigation differed, we argue that it is unwise to attempt to fit each study into the framework favored by Boles and Barth (2011).     

A laboratory analogue of mirrored-self misidentification delusion: The role of hypnosis,suggestion, and demand characteristics

Mirrored-self misidentification is the delusional belief that one’s own reflection in the mirror is a stranger. In two experiments, we tested the ability of hypnotic suggestion to model this condition. In Experiment 1, we compared two suggestions based on either the delusion’s surface features (seeing a stranger in the mirror) or underlying processes (impaired face processing). Fifty-two high hypnotisable participants received one of these suggestions either with hypnosis or without in a wake control. In Experiment 2, we examined the extent to which social cues and role-playing could account for participants’ behaviour by comparing the responses of 14 hypnotised participants to the suggestion for impaired face processing (reals) with those of 14 nonhypnotised participants instructed to fake their responses (simulators). Overall, results from both experiments confirm that we can use hypnotic suggestion to produce a compelling analogue of mirrored-self misidentification that cannot simply be attributed to social cues or role-playing.     

The use of visual context during the production of referring expressions

Most theories of reference assume that a referent's saliency in the linguistic context determines the choice of referring expression. However, it is less clear whether cognitive factors relating to the nonlinguistic context also have an effect. We investigated whether visual context influences the choice of a pronoun over a repeated noun phrase when speakers refer back to a referent in a preceding sentence. In Experiment 1, linguistic mention as well as visual presence of a competitor with the same gender as the referent resulted in fewer pronouns for the referent, suggesting that both linguistic and visual context determined the choice of referring expression. Experiment 2 showed that even when the competitor had a different gender from the referent, its visual presence reduced pronoun use, indicating that visual context plays a role even if the use of a pronoun is unambiguous. Thus, both linguistic and nonlinguistic information affect the choice of referring expression.     

Increased Stroop interference with better second-language reading skill

Skilled readers demonstrate remarkable efficiency in processing written words, unlike beginning readers for whom reading occurs more serially and places higher demands on visual attention. In the present study, we used the Stroop paradigm to investigate the relationship between reading skill and automaticity, in individuals learning a second language with a different orthographic system. Prior studies using this paradigm have presented a mixed picture, finding a positive, a negative, or no relationship between the size of Stroop interference and reading skills. Our results show that Stroop interference in the second language was positively related to reading skill (when controlled for interference in the first language). Furthermore, interference was positively related to objective but not subjective indices of the amount of exposure to the second language. We suggest that the lack of consistency in the results of earlier studies may be due, at least in part, to these studies looking at Stroop interference in isolation, rather than comparing interference between languages.     

Questioning implicit motor learning as instantiated by the pursuit-tracking task

The effect of concurrent visual feedback on the implicit learning of repeated segments in a task of pursuit tracking has been tested. Although this feedback makes it possible to regulate the positional error during the movement, it could also induce negative guidance effects. To test this hypothesis, a first set of participants (N?=?42) were assigned to two groups, which performed either the standard pursuit-tracking task based on the experimental paradigm of Pew (1974 Pew, R. W. 1974. Levels of analysis in motor control. Brain Research, 71: 393–400. [Crossref], [PubMed], [Web of Science ®] , [Google Scholar]; group F-ST), or a task called “movement reproduction” in which the feedback was suppressed (group noF-ST). A second set of participants (N?=?26) performed in the same feedback condition groups but in a dual-task situation (F-DT and noF-DT; Experiment 2). The results appear to confirm our predictions since the participants in groups without feedback, contrary to those in groups with feedback, succeeded with practice in differentiating their performances as a function of the nature of the segments (repeated or nonrepeated) both in simple (Experiment 1) and in dual-task (Experiment 2) situations. These experiments indicate that the feedback in the pursuit-tracking task induces a guidance function potentially resulting in an easiness tracking that prevents the participants from learning the repetition.