干预胆碱M受体对药物成瘾的影响及其与多巴胺的关系

药物成瘾是一类精神及行为障碍, 涉及到中枢神经系统的病变。毒蕈碱受体(Muscarinic receptor, M受体)属于胆碱能受体, 分5种亚型。行为学研究表明, 干预M受体能有效影响药物成瘾行为, 但其神经机制还亟待探索。阿片类药物与精神活性药物均能激活中枢多巴胺系统, 而M受体与多巴胺系统在多个脑区产生了交互作用。其中激动M2及M4受体抑制了多巴胺系统功能, 而激动M5受体增强了多巴胺系统功能, 与干预M2、M4、M5受体对药物成瘾行为的影响相对应。以上证据提示, 干预M受体可能通过影响多巴胺系统对药物成瘾起作用。     

大连地区企业医院产权制度改革的实践与思考

企业医院社会化是区域卫生规划与卫生工作实行全行业管理的前提条件,也是国企改革和社会改革的需要,医企分离势在必行.在企业医院剥离过程中,医院产权制度改革已经成为医院改革的主要矛盾和深化医院改革的首要问题.通过大连地区企业医院产权制度改革的实践经验,对企业医院剥离模式进行探讨,阐述了对医院产权制度改革的认识,并提出合理化建议.     

胸腺功能的发现及其对免疫学发展的影响

19世纪60年代初,免疫系统的发现使免疫学的发展方向发生了革命性转变。在这场转变的过程中,胸腺功能的发现起到了重要的作用。详述了胸腺功能的发现过程,并进一步深入到免疫学思想史,讨论了这个发现如何影响了免疫学的历史进程。     

Experience-grounded semantics: a theory for intelligent systems

An experience-grounded semantics is introduced for an intelligent reasoning system, which is adaptive, and works with insufficient knowledge and resources. According to this semantics, truth and meaning are defined with respect to the experience of the system – the truth value of a statement indicates the amount of available evidence, and the meaning of a term indicates its experienced relations with other terms. The major difference between experience-grounded semantics and model-theoretic semantics is that the former does not assume the sufficiency of knowledge and resources. This approach provides new ideas to the solution of some important problems in cognitive science.     

Why do residents accept a demanding rule?: Fairness and social benefit as determinants of approval of a recycling system1,2

Abstract: This study examined why people accepted a demanding rule in a recycling system that was newly introduced in Nagoya City. We focused on two social psychological topics: social dilemmas and fairness. While the new system succeeded in reducing waste, it imposed a burden on citizens without providing incentives and sanctions. In a research survey, 1442 responses from a sample of 3000 (48% response rate) were obtained using a stratified sampling method. The results showed that the new recycling system was approved despite the demands placed on citizens, with a preference for more strict rules such as penalties and surveillance for noncompliance. The main determinants of approval of the new recycling system were social benefit and procedural fairness, whereas the main determinant of preference for strict rules was outcome fairness. We argue that (a) social benefit should be emphasized to facilitate cooperative behavior in a social dilemma situation and (b) the government should ensure sufficient discussion with citizens and acknowledgment of their opinions.     

仿生医学--一个新的医学理论体系的创立

医学发展呼唤原始性创新.大自然是人类创新的不竭源泉,国际上仿生学研究如火如荼.为了强化将仿生方法、仿生技术贯穿到科研创新的全过程,引导医学科技人员巧妙寻找源头创新,率先提出创立仿生医学体系,并初步建立起仿生医学的学科框架,以便更好地把握学科前沿和判断发展趋势,为我国在仿生医学学科领域的领先作用奠定重要基础.     

Social Dominance Theory: Its Agenda and Method

The theory has been misconstrued in four primary ways, which are often expressed as the claims of psychological reductionism, conceptual redundancy, biological reductionism, and hierarchy justification. This paper addresses these claims and suggests how social dominance theory builds on and moves beyond social identity theory and system justification theory.     

从医生和医院角度透视医患关系

医患关系一直以来都是临床医学实践的核心问题和基础,受多因素影响,包括患者、医生(医院)和社会.在医患关系不和谐的今天,如何以系统论方法,从医生和医院角度分析制约医患关系健康发展症结,是每个医生和医院管理者需认真思考和对待的问题.而发扬人文主义精神,坚持"以病人为中心"理念,是医生和医院缓解日益加剧的医患矛盾,从根本上改善医患关系的前提.     

我国传染病防治面临的形势与对策

长期以来由于种种原因对新发传染病和再发传染病防控方面存在许多问题,比如认识上不足、缺乏投入、设施陈旧、专业人员短缺、农村是薄弱环节等,在SARS暴发过程中表现更为严重,迫切地要求建立一完整套的、科学的、符合中国国情的应对各种新发或再发传染病的公共卫生应急系统.