帕金森病诊断标记物系统回顾与展望

本篇综述总结了帕金森病的诊断、鉴别诊断和病程监测的各领域的生物学标记物的研究进展。其中重点介绍了神经影像学和生物化学领域的生物学标记物,也是当前研究较为成熟的两大领域。神经影像学标记物以多巴胺能影像及非多巴胺能影像为代表,生物化学标记物为包括a一突触核蛋白在内的多种蛋白和激素,两者的结合能够有效提高疾病诊断的特异性和灵敏性。同时文章还介绍了当前研究的热点——帕金森病的前驱诊断手段,即在疾病典型的运动症状和非运动症状出现前便可预测帕金森病的诊断手段。     

炎症性肠病的药物治疗现状及进展

炎症性肠病（IBD）病程迁延反复,影响患者生活质量,耗费卫生资源。虽然传统药物如5-氨基水杨酸、糖皮质激素、免疫抑制剂等仍是目前治疗主流,但是大量有关发病机制的研究以及循证医学的发展对IBD的治疗产生了积极的推进作用。IBD的治疗正步入免疫调节的生物学时代,多种新型生物制剂的出现为IBD的治疗提供了新的策略和选择。现就目前IBD药物治疗现状以及最新进展进行综述,以期对临床IBD治疗提供参考。     

Zuckerkandl结节在甲状腺手术中对上甲状旁腺的定位与保护

探讨Zuckerkandl结节（ZT）在甲状腺手术中对上甲状旁腺的定位与保护作用.对我院2011年10月至2013年1月在我院行甲状腺手术患者351例进行回顾分析,结果显示,ZT在左侧叶甲状腺的发生率为89.0％（268/301）,右侧叶中的发生率为87.3％（254/291）,共计5例患者出现术后甲状旁腺功能一过性下降,未有永久性甲状旁腺功能损失患者出现.ZT为甲状腺手术中探查上甲状旁腺提供了新的途径与解剖标志,值得引起甲状腺外科医生的关注.     

阿尔茨海默病的诊治新进展

流行病学数据的更新表明阿尔茨海默病（A D ）已成为全球健康问题。早期应用生物标志物的AD新诊断标准广泛应用和临床试验不断失败的鲜明反差提示AD治疗的艰巨性。AD和其他慢性疾病的共病研究不断深入。生活方式干预作为非药物治疗备受重视。     

隆乳术的演变与进步

隆乳术不仅可以重塑女性的形体美,而且可以增强女性的自信心,在当前具有广阔的市场。纵观隆乳术的发展演变史,从最初的注射隆乳术到自体组织隆乳术,再到当前的假体隆乳术和自体脂肪移植隆乳术,经历了“实践、认识、再实践、再认识”的多次反复。各种隆乳方式各具特色,其间既有成功的经验,又有失败的教训。针对隆乳术安全性的改进推动了隆乳术的不断向前发展。寻找一种安全有效的隆乳方式和理想的隆乳材料成为当前隆乳术发展的关键和整形外科医师关注的重点。     

Client as expert: A Delphi poll of clients’ subjective experience of therapeutic alliance formation variables

This study extends prior research that identified client-derived variables believed to contribute to therapeutic alliance development. Forty-two clients participated in a three-round-modified Delphi poll in which the subjective importance of 74 client-derived, common alliance formation variables was rated using a six-point scale. Participants consensually identified 23 variables as highly important, five as moderately important and three as low in importance to the formation of a strong alliance. Variables related to validation and asking about parts of the client’s life other than the presenting concern were considered as most important by at least one-third of the sample. Limitations of the study are presented and implications for theory, measurement, practice and future research are briefly discussed.     

On the logical structure of de Finetti's notion of event

This paper sheds new light on the subtle relation between probability and logic by (i) providing a logical development of Bruno de Finetti's conception of events and (ii) suggesting that the subjective nature of de Finetti's interpretation of probability emerges in a clearer form against such a logical background. By making explicit the epistemic structure which underlies what we call Choice-based probability we show that whilst all rational degrees of belief must be probabilities, the converse doesn't hold: some probability values don't represent decision-relevant quantifications of uncertainty.     

母亲抑郁情绪对幼儿内化问题的影响：有调节的中介模型

采用问卷法对298名6个月婴儿的母亲进行为期8个月的追踪,通过交叉滞后回归以及多层回归分析探究母亲抑郁情绪与母亲教养压力的准因果关系,母亲抑郁情绪与幼儿内化问题间的有调节的中介效应。结果表明：（1）母亲抑郁情绪与母亲教养压力存在准因果关系,母亲抑郁情绪可显著正向预测母亲的教养压力。（2）母亲感受到的教养压力对母亲抑郁情绪与幼儿内化问题的关系具有部分中介效应。母亲抑郁情绪不仅对幼儿内化问题产生直接影响,也可通过母亲的教养压力对幼儿内化问题产生间接影响。不过这一中介模型受母亲受教育程度的调节。只有在母亲受教育程度低时,教养压力对母亲抑郁情绪与幼儿内化问题的中介作用才成立,母亲较高的受教育程度可以明显减弱由于母亲抑郁情绪对幼儿内化问题的影响。这在一定程度上揭示了母亲抑郁情绪对幼儿内化问题的影响机制,对缓解母亲抑郁水平高的幼儿的内化问题提供理论和参考价值。     

Parents' depressive symptoms and children's adjustment over time are mediated by parenting,but differentially for fathers and mothers

Parenting has been found to act as a mediator of the relation between parents' depressive symptoms and children's adjustment. The present study replicated this result, and also found specific effects of gender for both parents and children. A total of 319 parents provided reports of their depressive symptoms (BDI) and two parenting styles (APQ; inconsistent discipline and positive parenting) as well as of their elementary schoolchildren's adjustment (VBV-EL; oppositional-defiant behaviour, hyperactivity, internalizing, social-emotional competence). The first and second measurement occasions were six months apart. Bivariate correlations showed the expected pattern of positive associations between parental depression, child maladjustment and problematic parenting. However, the results differed for mothers and fathers, and the mediation was moderated by the children's gender. Inconsistent discipline was a mediator for both fathers and mothers. The path from fathers' depression was additionally negatively mediated by positive parenting. Boys were more vulnerable than girls.     

Travailler dans un réseau de santé : effets sur la santé psychique au travail

The new needs as regards care taking charge of patients have contributed to the creation of health networks. As they are growing fast, they are an integral part of the French sanitation system. The impact, on the health professionals, of networking is, today, the object of contrasted research and results, but has little been studied as far as Social Psychology, Work and Organizations are concerned. This article follows a research project which had the objective, on the one hand, to describe the effects of the participation to a health network mental health at work and, on the other hand, to examine the variables and process accounting for the variability of these effects. This research privileges an approach to the health network as a place of socialization and personalization (Malrieu, 1979). The research on the ground is carried out in collaboration with the health network town-hospital Prevention and Taking charge of Pediatric Obesity Network (RéPPOP) Midi-Pyrénées. We have carried out semi-guided interviews with 20 private professionals (8 doctors, 8 dieticians, 3 psychologists, 1 physiotherapist) members of the RePPOP Midi-Pyrénées network. The main results show that the perception of positive and/or negative effects of networking on mental health varies according to the age of membership of the network and the processes of transfer of experience (from professional practice within the network to professional practice off-network and vice versa). Proposals are deduced in terms of continuing education within the network.