Sluggish cognitive tempo in children and adolescents with higher functioning autism spectrum disorders: Social impairments and internalizing symptoms

Sluggish cognitive tempo (SCT) was introduced in 1980s in the field of attention deficit hyperactivity disorder (ADHD). Studies indicate that symptoms of SCT are separate from symptoms of ADHD and independently associated with multiple domains of functioning in clinical groups and in typical development. We assessed whether similar pattern would apply to higher functioning autism spectrum disorders (ASD). Children with higher functioning ASD (N = 55; 5?15 years) were divided into the ASD+High SCT (n = 17), the ASD+Medium SCT (n = 18) and the ASD+Low SCT (n = 20) groups based on parent‐rated daydreaming and slowness on the Five to Fifteen questionnaire (FTF). The groups were compared on SCT‐related impairments found in previous studies: social skills, academic functioning, psychiatric symptoms, and processing speed. Assessment methods were the FTF, the Development and Well‐Being Assessment, and the Coding subtest of the WISC‐III. The ADHD symptoms were statistically controlled due to the overlap between SCT and ADHD. The ASD+High SCT and ASD+Medium SCT groups were significantly more likely to have the most pronounced social impairments, and the ASD+High SCT group had significantly higher rate of internalizing disorders compared to the ASD+Low SCT group. Our results suggest that children with higher functioning ASD and high or medium levels of SCT symptoms could be at higher risk for psychosocial impairments than children with higher functioning ASD with low levels of SCT symptoms. Co‐occurring ADHD symptoms do not explain the finding. Recognizing SCT symptoms in higher functioning ASD would be important to targeting preventive support.     

心肾贫血综合征的系统思维

心肾贫血综合征在慢性肾脏疾病患者和慢性心衰患者中大有人在,并日益受到医生重视,对其的正确认识及治疗直接影响患者的疾病预后.因此我们深入认识心肾贫血综合征及研究新的临床防治策略时,有必要着眼于心肾贫血综合征的内在特征并运用系统学方法原理分析其特点,为临床防治提供科学指导。     

The effects of variable-time delivery of food items and praise on problem behavior reinforced by escape

Prior research indicates that reinforcement of an appropriate response (e.g., compliance) can produce concomitant reductions in problem behavior reinforced by escape when problem behavior continues to produce negative reinforcement (e.g., Lalli et al., 1999). These effects may be due to a preference for positive over negative reinforcement or to positive reinforcement acting as an abolishing operation, rendering demands less aversive and escape from demands less effective as negative reinforcement. In the current investigation, we delivered a preferred food item and praise on a variable-time 15-s schedule while providing escape for problem behavior on a fixed-ratio 1 schedule in a demand condition for 3 participants with problem behavior maintained by negative reinforcement. Results for all 3 participants showed that variable-time delivery of preferred edible items reduced problem behavior even though escape continued to be available for these responses. These findings are discussed in the context of motivating operations.     

女性不同时期高血压的临床特征与治疗原则

女性因在不同时期内分泌的变化使其血压变化规律与男性有异,本文阐述了女性不同时期血压的临床特征和治疗原则;妊娠前及妊娠期慢性高血压的治疗及降压药物的选择;妊娠高血压综合征的处理原则及授乳期安全哺乳方法。     

血液净化防治多器官功能障碍综合征的思考

血液净化防治多器官功能障碍综合征已在临床医疗中广泛应用。简要介绍血液净化及多器官功能障碍综合征的相关知识。重点运用科学思维分别从系统论方法、控制论方法、信息方法三方面阐述两者间的内在联系,为临床工作提供新的指导。     

利益相关者分析方法在卫生政策改革中的应用

利益相关者分析作为一种新的方法,已经广泛应用于西方国家的企业管理与卫生政策改革研究和实践中,并取得初步成效,但在我国尚未得到应有的重视.在介绍该方法的基础上,结合我国卫生改革的实际,对利益相关者分析方法在我国卫生政策改革中的应用问题进行了初步的探讨,力图为正处于转型时期的我国卫生改革政策的制定与实施提供新的视角.     

WISC-R Subtest But No Overall VIQ–PIQ Difference in Dutch Children with PDD-NOS

VIQ–PIQ differences have been studied in children with autism and Asperger syndrome but have not been studied in a separate group of children with PDD-NO, although, PDD-NOS has a much higher prevalence rate than autism and deficits in communication and social interaction are severe. The Wechsler Intelligence Scale for Children-Revised (WISC-R) was administered to 100 children, aged 6–12 years, with PDD-NOS (n = 76), autism (n = 13), and Asperger syndrome (n = 11). PDD-NOS was diagnosed using explicit research criteria. No overall differences between VIQ and PIQ were found in PDD-NOS and autism. Peaks in the subtest scores on Information, Similarities, Picture Arrangement, and Mazes, and troughs in the subtest scores on Comprehension, Digit Span, and Coding were demonstrated in children with PDD-NOS. Their score on the Freedom from Distractibility factor was lower than the scores on the Verbal Comprehension factor and the Perceptual Organization factor. Children with PDD-NOS seemed to have a similar VIQ–PIQ profile as children with autism, and on the subtest level children with PDD-NOS showed some similarities to children with Asperger syndrome or autism. It was not possible to distinguish PDD-NOS from autism or Asperger syndrome by using IQ scores.     

Room for a view: on the metaphysical subject of personal identity

Sydney Shoemaker leads today’s “neo-Lockean” liberation of persons from the conservative animalist charge of “neo-Aristotelians” such as Eric Olson, according to whom persons are biological entities and who challenge all neo-Lockean views on grounds that abstracting from strictly physical, or bodily, criteria plays fast and loose with our identities. There is a fundamental mistake on both sides: a false dichotomy between bodily continuity versus psychological continuity theories of personal identity. Neo-Lockeans, like everyone else today who relies on Locke’s analysis of personal identity, including Derek Parfit, have either completely distorted or not understood Locke’s actual view. Shoemaker’s defense, which uses a “package deal” definition that relies on internal relations of synchronic and diachronic unity and employs the Ramsey–Lewis account to define personal identity, leaves far less room for psychological continuity views than for my own view, which, independently of its radical implications, is that (a) consciousness makes personal identity, and (b) in consciousness alone personal identity consists—which happens to be also Locke’s actual view. Moreover, the ubiquitous Fregean conception of borders and the so-called “ambiguity of is” collapse in the light of what Hintikka has called the “Frege trichotomy.” The Ramsey–Lewis account, due to the problematic way Shoemaker tries to bind the variables, makes it impossible for the neo-Lockean ala Shoemaker to fulfill the uniqueness clause required by all such Lewis style definitions; such attempts avoid circularity only at the expense of mistaking isomorphism with identity. Contrary to what virtually all philosophers writing on the topic assume, fission does not destroy personal identity. A proper analysis of public versus perspectival identification, derived using actual case studies from neuropsychiatry, provides the scientific, mathematical and logical frameworks for a new theory of self-reference, wherein “consciousness,” “self-consciousness,” and the “I,” can be precisely defined in terms of the subject and the subject-in-itself.     

Autism Spectrum Symptomatology in Children: The Impact of Family and Peer Relationships

This study examines the potential impact of family conflict and cohesion, and peer support/bullying on children with autism spectrum disorder (ASD). While such impacts have been established for a range of non-ASD childhood disorders, these findings may not generalize to children with ASD because of unique problems in perspective-taking, understanding others’ emotion, cognitive rigidity, and social reasoning. A structural model-building approach was used to test the extent to which family and peer variables directly or indirectly affected ASD via child anxiety/depression. The sample (N = 322) consisted of parents of children with ASD referred to two specialist clinics. The sample contained parents of children with Autistic Disorder (n = 76), Asperger Disorder (n = 188), Pervasive Disorder Not Otherwise Specified (n = 21), and children with a non-ASD or no diagnosis (n = 37). Parents completed questionnaires on-line via a secure website. The key findings were that anxiety/depression and ASD symptomatology were significantly related, and family conflict was more predictive of ASD symptomatology than positive family/peer influences. The results point to the utility of expanding interventions to include conflict management for couples, even when conflict and family distress is low. Further research is needed on the potentially different meanings of family cohesion and conflict for children with ASD relative to children without ASD.     

直立位机械通气可行性的探讨

机械通气是治疗急性肺损伤／急性呼吸窘迫综合征（ALI／ARDS）的重要措施之一,本文从理论上探讨直立位机械通气的可行性,推测其可能的机制,与肺保护通气策略的关系,尚需要解决的问题,以期证明优于传统机械通气方式。