Mapping people's positions regarding the acceptability of somatic gene therapy

IntroductionAs gene therapy entails potential drawbacks, studies are needed in order to know people's opinions regarding its use.ObjectivesThe present study examined French people's positions regarding somatic gene therapy.MethodA sample of 224 adults living in various areas in France was presented with 32 realistic scenarios that were created by orthogonally combining the levels of four factors: the type of illness (e.g., hemophilia), the probability of transmission of the pathogenic gene, the technique used (e.g., transfer of a functional gene just after birth), and le probability of success of the therapy.ResultsThrough cluster analysis, six qualitatively different positions were found: Never very acceptable (8% of the sample, mostly males and more educated people), Legalist (17%, mostly people who have been informed of the legal and technical aspects of the therapy), Depends on the chances of success (18%), Fully acceptable after birth (5%), Fully acceptable before birth (8%), and Quite always acceptable (33%, mostly older people with children).ConclusionAlthough it has some few detractors, the recourse to gene therapy seems to be well accepted by a majority of the participants, and this high level of acceptation hold whether the pathology considered is hemophilia, immunodeficiency, propensity to develop cancer, or cardiovascular pathology.     

Bridging ears and eyes when learning spoken words: On the effects of bilingual experience at 30 months

From the very first moments of their lives, infants selectively attend to the visible orofacial movements of their social partners and apply their exquisite speech perception skills to the service of lexical learning. Here we explore how early bilingual experience modulates children's ability to use visible speech as they form new lexical representations. Using a cross‐modal word‐learning task, bilingual children aged 30 months were tested on their ability to learn new lexical mappings in either the auditory or the visual modality. Lexical recognition was assessed either in the same modality as the one used at learning (‘same modality’ condition: auditory test after auditory learning, visual test after visual learning) or in the other modality (‘cross‐modality’ condition: visual test after auditory learning, auditory test after visual learning). The results revealed that like their monolingual peers, bilingual children successfully learn new words in either the auditory or the visual modality and show cross‐modal recognition of words following auditory learning. Interestingly, as opposed to monolinguals, they also demonstrate cross‐modal recognition of words upon visual learning. Collectively, these findings indicate a bilingual edge in visual word learning, expressed in the capacity to form a recoverable cross‐modal representation of visually learned words.     

Evaluating the effectiveness of Didi ride-hailing security measures: An integration model

Security is one of the most critical factors influencing individuals’ mobility. Ensuring security along ride-hailing trips is also a fundamental challenge to service providers. After two cases of rape and homicide, Didi has rectified measures again to meet passengers’ need for security. However, there are few scientific findings concerning the impact of Didi rectified measures on personal perception of security. This study aims to explore critical latent factors that affect individuals’ intentions to use or reuse ride-hailing after the rectification of security measures. This paper examines individuals’ usage intentions by integrating and expanding both the Technology Acceptance Model (TAM) and the Theory of Planned Behavior (TPB). Research results suggest that perceived security, security risk, and government credibility are correlated with the intentions to use or reuse ride-hailing. Importantly, perceived security and security risk both have a direct impact on behavioral intentions from a different perspective. In contrast, government credibility has an indirect effect. Hence, a mediating effect test is conducted. Government credibility could indirectly influence behavioral intention by affecting trust. Finally, this study verifies that the effectiveness of security measures could be evaluated and improved by studying the influence of latent factors on the intentions to use or reuse ride-hailing.     

Safety of micro-mobility: Riders’ psychological factors and risky behaviors of cargo TTWs in China

Cargo two- or three-wheeled vehicles (TTWs), as a new form of micro-mobility, have become a popular mode of urban cargo transportation in China. Cargo TTW riders’ psychological factors and risky behaviors lead to a number of accidents. A questionnaire is designed by comprehensively considering these factors and behaviors of cargo TTW riders that includes eleven risk factors to quantitatively analyze the risky behaviors based on structural equation modeling (SEM). One thousand three hundred nineteen participants reported using cargo TTWs on a questionnaire distributed across the country. The characteristics of riding behavior data are analyzed to verify the three-layer risk theoretical framework of “Psychological factors (Personality traits/specific factors) - Psychological acceptability of risks (confidence/perception/attitude) - Risky behaviors”. The results show that anger has a strong direct effect on riding violations, while normlessness and altruism have a direct effect on riding errors. Workload has a weak but direct effect on risky behaviors, and riding feedback has a weak and mixed effect. In addition, high-risk groups are identified by analysis of variance (ANOVA) with rider population attributes. These quantitative analyses can help guide safety countermeasures to mitigate accidents involving cargo TTWs.     

An adaptive network model covering metacognition to control adaptation for multiple mental models

Learning processes can be described by adaptive mental (or neural) network models. If metacognition is used to regulate learning, the adaptation of the mental network becomes itself adaptive as well: second-order adaptation. In this paper, a second-order adaptive mental network model is introduced for metacognitive regulation of learning processes. The focus is on the role of multiple internal mental models, in particular, the case of visualisation to support learning of numerical or symbolic skills. The second-order adaptive network model is illustrated by a case scenario for the role of visualisation to support learning multiplication at the primary school.     

De l’estime de soi et du sentiment d’auto-efficacité à la motivation au travail : le rôle médiateur du sens du travail chez les alternants en France

The purpose of this study was to test the links between self-esteem, the feeling of self-efficacy and the different forms of motivation. It also aimed to understand the mediating effect of the meaning of work between the variables. French work-integrated learning students (n = 471) completed a self-administered online questionnaire. The results showed significant links between self-esteem, perceived self-efficacy, work meaning, and different dimensions of motivation (extrinsic, intrinsic, and amotivation). In addition, the meaning of work played a mediating role in the relationship between self-esteem, perceived self-efficacy, and dimensions of motivation. This study showed the central mechanism of work meaning in work motivation.     

树大招风：社交焦虑者的正性评价恐惧

正性评价恐惧是社交焦虑能够有效鉴别于抑郁症的核心特征。正性评价恐惧是指对他人给予的积极评价感到恐惧, 并因此而担忧的一种情绪反应。正性评价恐惧不仅会使社交焦虑者表现出否认积极认知、回避关注及情绪消极化等特点, 还会通过去正性化思维和解释偏向进一步加剧其认知偏差并抑制其正性情绪, 从而维持和加剧个体的社交焦虑症状。未来研究应关注正性评价恐惧在教育和咨询中的应用, 以及本土倡导谦虚文化背景下正性评价恐惧特点的研究。     

辩证行为疗法：理论背景、治疗效果及作用机制

辨证行为疗法（Dialectical Behavior Therapy, DBT）于20世纪90年代初由美国治疗师Linehan创立。作为第三代行为治疗之一,该疗法以行为主义理论、辩证哲学、生物社会理论及禅宗为哲学基础,通过增加患者的技能使用,提高其情绪调节能力,以达到治疗目的。临床研究已证明其在边缘人格障碍,自杀及自伤行为中具有良好的治疗效果,除此之外也广泛适用于其他心理障碍及群体。DBT的临床效果、改变机制及拓展应用都需进一步研究。     

正式反馈的发展与临床应用

摘要:正式反馈通过系统收集当事人的效果反馈来追踪其治疗进展,进而识别缺乏治疗进展的个案,并通过促进治疗策略的调整来阻止治疗失败。正式反馈是近20年来发展出的一种循证治疗手段,其目的为进一步提高当事人的咨询效果。正式反馈的发展大致经历了临床有效性检验和实用性发展两个阶段。正式反馈可用于促进个体、夫妻和团体咨询的效果,也可用于评估临床督导效果、确定督导个案和指导临床督导。未来研究可探讨咨询师对待正式反馈的态度,拓展正式反馈的使用价值,建立正式反馈系统的本土化常模。