Connecting action control and agency: Does action-effect binding affect temporal binding?

The sense of agency, i.e., the notion that we, as agents, are in control of our own actions and can affect our environment by acting, is an integral part of human volition. Recent work has attempted to ground agency in basic mechanisms of human action control. Along these lines, action-effect binding has been shown to affect explicit judgments of agency. Here, we investigate if such action-effect bindings are also related to temporal binding which is often used as an implicit measure of agency. In two experiments, we found evidence for the establishment of short-term action-effect bindings as well as temporal binding effects. However, the two phenomena were not associated with each other. This finding suggests that the relation of action control and agency is not a simple one, and it adds to the evidence in favor of a dissociation between subjective agency and perceptual biases such as temporal binding.     

Temporal processing dysfunction in schizophrenia

Schizophrenia may be associated with a fundamental disturbance in the temporal coordination of information processing in the brain, leading to classic symptoms of schizophrenia such as thought disorder and disorganized and contextually inappropriate behavior. Despite the growing interest and centrality of time-dependent conceptualizations of the pathophysiology of schizophrenia, there remains a paucity of research directly examining overt timing performance in the disorder. Accordingly, the present study investigated timing in schizophrenia using a well-established task of time perception. Twenty-three individuals with schizophrenia and 22 non-psychiatric control participants completed a temporal bisection task, which required participants to make temporal judgments about auditory and visually presented durations ranging from 300 to 600 ms. Both schizophrenia and control groups displayed greater visual compared to auditory timing variability, with no difference between groups in the visual modality. However, individuals with schizophrenia exhibited less temporal precision than controls in the perception of auditory durations. These findings correlated with parameter estimates obtained from a quantitative model of time estimation, and provide evidence of a fundamental deficit in temporal auditory precision in schizophrenia.     

Levels of Criticism: Handling Popperian Problems in a Popperian Way

Popper emphasised both the problem-solving nature of human knowledge, and the need to criticise a scientific theory as strongly as possible. These aims seem to contradict each other, in that the former stresses the problems that motivate scientific theories while the one ignores the character of the problems that led to the formation of the theories against which the criticism is directed. A resolution is proposed in which problems as such are taken as prime in the search for knowledge, and subject to discussion. This approach is then applied to the problem of induction. Popper set great stake to his solution of it, but others doubted its legitimacy, in ways that are clarified by changing the form of the induction problem itself. That change draws upon logic, which is the subject of another application: namely, in contrast to Popper’s adhesion to classical logic as the only welcome form (because of the maximal strength of criticism that it dispenses), can other logics be used without abandoning his philosophy of criticism?     

Basal ganglia, dopamine and temporal processing: performance on three timing tasks on and off medication in Parkinson's disease

A pervasive hypothesis in the timing literature is that temporal processing in the milliseconds and seconds range engages the basal ganglia and is modulated by dopamine. This hypothesis was investigated by testing 12 patients with Parkinson's disease (PD), both 'on' and 'off' dopaminergic medication, and 20 healthy controls on three timing tasks. In a seconds range (30-120 s) time production task, patients tested 'on' medication showed a significantly different accuracy profile compared to controls and when tested 'off' medication. However, no group or on vs off medication differences in accuracy were found on a time reproduction task and a warned reaction time task requiring temporal processing within the 250-2000 ms range. Variability was measured using the coefficient of variation, with the performance of the patient group on the time reproduction task violating the scalar property, suggesting atypical temporal processing mechanisms. The data suggest that the integrity of the basal ganglia is necessary for 'typical' time production in the seconds range as well as for time reproduction at shorter intervals. Exploratory factor analysis suggested that the time production task uses neural mechanisms distinct from those used in the other two timing tasks. The dissociation of the effects of dopaminergic medication and nature of task on performance in PD raises interesting questions about the pharmacological mediation and task-specificity of deficits in temporal processing.