IGFBP-2及IGFBP-6在结直肠癌中的表达及意义

研究胰岛素样生长因子结合蛋白2（IGFBP-2）及胰岛素样生长因子结合蛋白6（IGFBP-6）在结直肠癌中的表达及临床意义。采用免疫组织化学法及RT-PCR方法检测结直肠癌、结直肠腺瘤及癌旁正常黏膜组织中IGFBP-2及IGFBP-6的蛋白及mRNA的表达情况,结合临床病理资料进行统计学分析。IGFBP-2及IGFBP-6蛋白的阳性表达及mRNA的表达量在三组组织中均存在异常表达情况,且差异有明显的统计学意义（P〈0.05）,在结直肠癌组IGFBP-2、IGFBP-6的阳性表达在肿瘤浸润深度、有无淋巴结转移及Duke＇s分期存在差异,有明显的统计学差异（P〈0.05）。临床可以把二者作为结直肠癌诊断及预后的早期预测指标。     

Lower back pain in nurses working in home care: linked to work–family conflict,emotional dissonance,and appreciation?

In industrial countries home care services for elderly people living in the community are growing rapidly. Home care nursing is intensive and the nurses often suffer from musculoskeletal pain. Time pressure and job control are job-related factors linked to the risk of experiencing lower back pain (LBP) and LBP-related work impairment. This survey investigated whether work-family conflict (WFC), emotional dissonance and being appreciated at work have incremental predictive value. Responses were obtained from 125 home care nurses (63% response rate). Multiple linear regression showed that emotional dissonance and being appreciated at work predicted LBP intensity and LBP-related disability independently of time pressure and job control. WFC was not a predictor of LBP-related disability in multiple regression analyses despite a zero-order correlation with it. Redesigning the working pattern of home care nurses to reduce the emotional demands and improve appreciation of their work might reduce the incidence of LBP in this group.     

Pedestrians’ road crossing decisions and body parts’ movements

This study aims to examine pedestrians' crossing decision, body parts' movement and full body movement, just before and during road crossing in a simulated setup. To accomplish this, a novel experimental setup for analyzing pedestrians’ crossing behavior and motion was developed where the simulated display was synchronized with a 3D motion capturing system. Twenty participants, divided into control and an experimental time pressure group, observed sixteen short (less than 30 s) and long road (70 s or more) crossing scenarios with varying crossing opportunities. Based on the crossing opportunities they were asked to cross a 3.6 m wide one-lane one way urban road. It was found that the crossing initiation process consists of four incremental movements of body parts: the head and the shoulder first; the hip, wrist and elbow second; the knee as a separate joint, and finally the ankle. Results showed that pedestrians’ decision to cross and body parts movement are influenced by time pressure and wait time for a safe crossing opportunity. Specifically, pedestrians prepare their body parts earlier, initiate their crossing earlier, and adjust their speed to compensate for the risk taken in less safe or non-safe crossing opportunities. Within the control group, women tended to be more risk avoiding than men, however those differences disappeared in the time pressure group. Most importantly, the findings provide initial evidence that this novel simulation configuration can be used to gain precise knowledge of pedestrians’ decision-making and movement processes.     

Making Time Protestant in Early-Modern Glasgow

This article, drawn largely from the under-utilized Kirk session records from late-sixteenth-century Glasgow, by way of example, demonstrates how changing dispositions towards time were at the heart of the Reformation change of religion in Scotland. From the expansion of time obligations of Christians, the alteration of holy days, and the re-definition of basic units of time, alternative understandings of time were among the most tangible effects of the establishment of Protestantism in Scotland. In introducing time as a new way to examine the broad influence of the Reformation on the lives of the Scottish people, the article builds on recent research on the European Reformations while also introducing new perspectives on the uniqueness of the Scottish case.     

Connecting the dots from a distance: Does mentally traveling through space and time increase searching for life’s meaning?

As humans, we have the ability to travel beyond the present moment by considering past and future times as well as locations that are distant from oneself. An interesting possibility is that such mental travel to far-away times and places (vs. focusing on times and places closer to the present) may increase people’s desire to search for their lives’ meaning. Since searching for meaning involves the integration of separate life events into a coherent life story, mentally traveling farther away from the present may make people aware that their life stories include more than what is happening at this very minute. Such awareness, then, may increase their desire to ‘connect the dots’ between their life events by searching for some underlying meaning. Three experiments (N = 838) tested this prediction and found that greater (vs. lower) mental travel through space or time increased the search for life’s meaning.     

The effect of different distractions on remembering delayed intentions

In safety-critical domains, frequently intentions need to be delayed until an ongoing task is completed. Research using the delay-execute paradigm showed that interruptions during the delay cause forgetting. However, staff members often handle an initial distraction not by interrupting the ongoing task but by acknowledging the distraction or multitasking. In Experiments 1a and 1b, we observed that, compared to a no distraction condition, multitasking significantly decreased remembering of intentions and interrupting decreased remembering even further. In Experiment 2, interruptions with context change reduced remembering of intentions compared to uninterrupted delays, and at the same time, interruptions without context change improved memory performance compared to uninterrupted delays. However, improved memory performance resulted in decreased interrupting task performance. Theoretically, the results support the contextual cueing mechanism of delay-execute tasks. Considering safety-critical domains, multitasking, interruptions and context changes can contribute to forgetting of tasks.     

Image memorability across longer time intervals

You may find some images easier to remember than others. Recent studies of visual memory have found remarkable levels of consistency for this inter-item variability across observers, suggesting that memorability can be considered an intrinsic image property. The current study replicated and extended previous results, while adopting a more traditional visual long-term memory task with retention intervals of 20 min, one day, and one week, as opposed to the previously used repeat-detection task, which typically relied on short retention intervals (5 min). Our memorability rank scores show levels of consistency across observers in line with those reported in previous research. They correlate strongly with previous quantifications and appear stable over time. Furthermore, we show that the way consistency of memorability scores increases with the number of responses per image follows the Spearman–Brown formula. Interestingly, our results also seem to show an increase in consistency with an increase in retention interval. Supported by simulated data, this effect is attributed to a decrease of extraneous influences on recognition over time. Finally, we also provide evidence for a log-linear, rather than linear, decline of the raw memorability scores over time, with more memorable images declining less strongly.     

How Cross‐Linguistic Differences in the Grammaticalization of Future Time Reference Influence Intertemporal Choices

According to Chen's (2013) Linguistic Savings Hypothesis (LSH), our native language affects our economic behavior. We present three studies investigating how cross‐linguistic differences in the grammaticalization of future‐time reference (FTR) affect intertemporal choices. In a series of decision scenarios about finance and health issues, we let speakers of altogether five languages that represent FTR with increasing strength, that is, Chinese, German, Danish, Spanish, and English, choose between hypothetical sooner‐smaller and later‐larger reward options. While the LSH predicts a present‐bias that increases with FTR‐strength, our decision makers preferred later‐larger options and this future‐bias increased with FTR‐strength. In multiple regressions, the FTR‐strength effect persisted when controlled for socioeconomic and cultural differences. We discuss why our findings deviate from the LSH and ask in how far the FTR‐strength effect represents a habitual constitution of linguistic relativity or an instance of online decision framing.     

Modeling Nonstationary Emotion Dynamics in Dyads using a Time-Varying Vector-Autoregressive Model

Emotion dynamics are likely to arise in an interpersonal context. Standard methods to study emotions in interpersonal interaction are limited because stationarity is assumed. This means that the dynamics, for example, time-lagged relations, are invariant across time periods. However, this is generally an unrealistic assumption. Whether caused by an external (e.g., divorce) or an internal (e.g., rumination) event, emotion dynamics are prone to change. The semi-parametric time-varying vector-autoregressive (TV-VAR) model is based on well-studied generalized additive models, implemented in the software R. The TV-VAR can explicitly model changes in temporal dependency without pre-existing knowledge about the nature of change. A simulation study is presented, showing that the TV-VAR model is superior to the standard time-invariant VAR model when the dynamics change over time. The TV-VAR model is applied to empirical data on daily feelings of positive affect (PA) from a single couple. Our analyses indicate reliable changes in the male’s emotion dynamics over time, but not in the female’s—which were not predicted by her own affect or that of her partner. This application illustrates the usefulness of using a TV-VAR model to detect changes in the dynamics in a system.     

Time–Frequency Cross Mutual Information Analysis of the Brain Functional Networks Underlying Multiclass Motor Imagery

To study the physiologic mechanism of the brain during different motor imagery (MI) tasks, the authors employed a method of brain-network modeling based on time–frequency cross mutual information obtained from 4-class (left hand, right hand, feet, and tongue) MI tasks recorded as brain–computer interface (BCI) electroencephalography data. The authors explored the brain network revealed by these MI tasks using statistical analysis and the analysis of topologic characteristics, and observed significant differences in the reaction level, reaction time, and activated target during 4-class MI tasks. There was a great difference in the reaction level between the execution and resting states during different tasks: the reaction level of the left-hand MI task was the greatest, followed by that of the right-hand, feet, and tongue MI tasks. The reaction time required to perform the tasks also differed: during the left-hand and right-hand MI tasks, the brain networks of subjects reacted promptly and strongly, but there was a delay during the feet and tongue MI task. Statistical analysis and the analysis of network topology revealed the target regions of the brain network during different MI processes. In conclusion, our findings suggest a new way to explain the neural mechanism behind MI.