探讨人乳头瘤病毒L1蛋白功能及其临床意义

高危型别人乳头瘤病毒（HPV）感染在宫颈癌发生发展中具有重要作用。由于HPV L1蛋白结构特征及其精确的抗原特性,在粘附宿主细胞、识别病毒受体、协助病毒DNA的入胞转运中均发挥重要作用。检测患者宫颈损伤组织中L1蛋白的表达将有助于对患者是否具有传染性进行评估。本文将深刻思考HPV L1功能及其在感染机体并引发癌变的机制,以期更好的解读宫颈癌发病原理并最终应用于,强床治疗。     

Lipo PGE1在肾移植中的应用

为了探讨前列腺素E1的脂微球载体靶向制剂（Lipo PGE1）对肾移植术后移植肾功能恢复和血流动力学的影响,80例肾移植受者在术后被随机分成两组：PGE1组和对照组。PGE1组从手术当天起至术后第14天每天给予静脉注射Lipo PGE1 20μg。比较两组术后尿量、血肌酐、彩色多普勒超声下移植肾收缩期最大血流速度（PSV）和血流阻力指数（RI）以及两组肾功能恢复延迟（DGF）的发生率。应用Lipo PGE1的患者术后尿量明显高于对照组（P〈0．05）,而血肌酐、PSV、RI和肾功能恢复延迟发生率则明显低于对照组（P〈0．05）。因此,前列腺素E1有利于肾移植术后移植肾功能的恢复,对肾移植术后早期肾动脉血流动力学有促进作用。     

Emotionally controlled decision-making and a gene variant related to serotonin synthesis in women with borderline personality disorder

The Iowa Gambling Task (IGT) was used to examine (i) social decision-making in women with borderline personality disorder (BPD), and (ii) the relationship between impaired decision-making and the tryptophan hydroxylase-1 (TPH-1) gene, involved in serotonin synthesis. Forty-two women with BPD and a history of suicide attempts were genotyped, and the frequency of a TPH-1 haplotype previously uniquely associated with BPD was calculated. The BPD group scored significantly lower than a control group in the IGT. Furthermore, the TPH-1 haplotype displayed a significantly higher frequency in BPD participants with impaired decision making, compared to BPD participants with normal scores. These findings suggest that impaired decision-making as determined by the IGT is a feature of BPD and may be (i) associated with serotonin dysfunction, and (ii) possibly relevant for suicidal behavior.     

Global Model Analysis of Cognitive Variability

Residual fluctuations produced in typical experimental methodologies are examined as correlated noises. The effective range of the correlations was assessed by determining whether the decay over look-back time is better described as a power law or exponential. Both of these decay laws contain free parameters and it is argued that it is not possible to distinguish their models on the basis of simple measures of goodness-of-fit. Global analyses that evaluate models on the basis of how well they generalize are conducted. The models are examined in terms of three constructs that all bear on generalization: cross-validity, flexibility, and representativeness. Quantitative assessment of a large ensemble of data suggests that the correlations decay over time as a power law. The conclusion is that human residual fluctuation is a correlated fractal.     

<Emphasis Type="Italic">Special Topic:</Emphasis> Confucian and Christian Conceptions of Creativity

In this article the concept of God as creativity (rather than as “the Creator”) is explored. Though creativity is a profound mystery to us humans, it is a plausible concept today because of its interconnectedness with the belief that our cosmos is evolutionary: new orders of reality come into being in the course of time. Three modalities of creativity are explored here: the initial coming into being of the universe (the Big Bang); the creativity manifest in evolutionary processes; the human creation of culture. It is suggested that this creativity itself should be thought of as God: God is creativity. Thus God-talk is given a referent that is specifiable in terms of today’s understandings of the world and the human. God remains a profound mystery here, but one with a significant place in our modern understanding of the world and human life. This article includes text and ideas taken from my book, In the beginning…Creativity (Kaufman 2004).     

Distinguishing between social reinforcement and social elicitation

The theoretical, procedural, analytic, and interpretive components of Poulson's (1983, Journal of Experimental Child Psychology, 36, 471–489) study were considered in an effort to clarify the distinction between social reinforcement and social elicitation. Contrary to Poulson's contention, DRO was not, and cannot by definition be, a control for reinforcement. More importantly, the speciestypical, social nature of the infant probably reflects the collaborative influence of elicitation and reinforcement. By carefully unravelling these two interacting processes, future conditioning studies might specially enhance our knowledge of early social development.     

Homotopic callosal inhibition

Previous theories concerning the function of the corpus callosum have included a “topographic” column-to-column excitatory theory and a diffuse “regional” inhibitory theory. Here it is shown that a topographic inhibitory model, in conjunction with a postulate concerning surround inhibition among cortical columns, produces complementary patterns of cortical column firing which, although qualitatively different, do not imply quantitative metabolic asymmetries. The cognitive implications of such homotopic inhibition are discussed.     

Left hemisphere superiority for pronounceable nonwords,but not for unpronounceable letter strings

Right-handed adults were asked to identify bilaterally presented linguistic stimuli under three experimental conditions. In Condition A, stimuli were three-letter pronounceable nonwords (such as TUP), and subjects were asked to report them by naming them. In Condition B, stimuli were three-letter pronounceable nonwords, and subjects were asked to report them as strings of letters. In Condition C, stimuli were more or less unpronounceable letter strings (such as UTP) created by rearranging the letters of pronounceable nonwords, and subjects reported them as strings of letters. Pronounceable nonwords were found to be better identified from the right visual hemifield irrespective of the way in which they were reported. Unpronounceable letter strings did not produce any visual hemifield difference. Nonwords are of interest because they can be seen as potential words that lack both specific semantic properties and entries in the subject's internal lexicon. The results of the experiment are consistent with the view that both the left and right cerebral hemispheres are able to identify letters but the left hemisphere is more sensitive to the pronounceability of the nonwords. This may happen either because the left hemisphere can make better use of resemblances to real words or because it has access to spelling to sound correspondence rules.     

A developmental perspective on reading dysfunction: Accuracy and rate criteria in the subtyping of dyslexic children

Children referred with specific reading dysfunction were subtyped as accuracy disabled or rate disabled according to criteria developed from an information processing model of reading skill. Multiple measures of oral and written language development were compared for two subtyped samples matched on age, sex, and IQ. The two samples were comparable in reading fluency, reading comprehension, word knowledge, and word retrieval functions. Accuracy disabled readers demonstrated inferior decoding and spelling skills. The accuracy disabled sample proved deficient in their understanding of oral language structure and in their ability to associate unfamiliar pseudowords and novel symbols in a task designed to simulate some of the learning involved in initial reading acquisition. It was suggested that these two samples of disabled readers may be best described with respect to their relative standing along a theoretical continuum of normal reading development.     

Hearing your voice through bone and air: Implications for explanations of stuttering behavior from studies of normal speakers

Cherry and Sayers (1956) reported that stutterers have problems dealing with sound fed back to the ears through bone. Their experimental support for this claim is reexamined. It is shown that their technique does not produce the same bone-conducted feedback as produced by the speaker while speaking. Their results are reinterpreted as showing that stutterers have problems when speaking in the presence of low frequency sound because of its masking properties, rather than because the sound originates in bone-conducted feedback.