Responding under sequence schedules of electric shock presentation

Lever pressing by squirrel monkeys was examined under second-order schedules of electric shock presentation in which different discriminative stimuli were associated with consecutive components (sequence schedules). Components were always two-minute fixed-interval schedules, and three different overall schedules were studied. Under an overall eight-minute fixed-interval schedule, the first component completion after at least eight minutes had elapsed produced electric shock. The number of components actually completed ranged from one to four; thus, different discriminative stimuli were occasionally associated with electric shock presentation. Under an overall “yoked” variable-ratio schedule, electric shock was presented after completion of a variable number of components; the required number and the distribution of components were matched to those obtained under the overall eight-minute fixed-interval schedule. Under an overall fixed-ratio schedule, electric shock was presented after completion of four components (chained schedule). Under all three sequence schedules, responding in early components was characterized by a pause followed by a single response after the end of the two-minute interval; responding in later components was characterized by a shorter pause followed by positively accelerated responding. Manipulation of overall schedules of shock presentation in these complex behavioral situations produced changes in responding comparable to those ordinarily obtained after similar manipulation of dependencies under both single and second-order schedules of food presentation. These experiments extend the range of conditions and levels of complexity under which responding can be maintained by presentation of electric shock.     

Subtask analysis of process data through a predictive model

Response process data collected from human–computer interactive items contain detailed information about respondents' behavioural patterns and cognitive processes. Such data are valuable sources for analysing respondents' problem-solving strategies. However, the irregular data format and the complex structure make standard statistical tools difficult to apply. This article develops a computationally efficient method for exploratory analysis of such process data. The new approach segments a lengthy individual process into a sequence of short subprocesses to achieve complexity reduction, easy clustering and meaningful interpretation. Each subprocess is considered a subtask. The segmentation is based on sequential action predictability using a parsimonious predictive model combined with the Shannon entropy. Simulation studies are conducted to assess the performance of the new method. We use a case study of PIAAC 2012 to demonstrate how exploratory analysis for process data can be carried out with the new approach.     

构建病人自主择医的现代医学伦理观

“病人选择医生”这一重大改革举措可以得到病人自主择医权和改革实践的有力辩护与支持,同时,为使其形成有序合理格局,并进入可持续发展的正常轨道,也亟需以解决现实重大问题为基础,着力的构建病人自主择医权的现代医学伦理观。这个医学伦理观应由现代的伦理理念框架1管理伦理框架、程序伦理框架构筑成主体框架。     

Age-related differences in sequence learning: Findings from two visuo-motor sequence learning tasks

The Serial Reaction Time Task (SRTT) is thought to assess implicit learning, which seems to be preserved with age. However, the reaction time (RT) measures employed on implicit-like tasks might be too unreliable to detect individual differences. We investigated whether RT-based measures mask age effects by comparing the performance of 43 younger and 35 older adults on SRTT and an explicit-like Predictive Sequence Learning Task (PSLT). RT-based measures (difference scores and a ratio) were collected for both tasks, and accuracy was additionally measured for PSLT. We also measured fluid abilities. The RT-difference scores indicated preserved SRTT and PSLT performance with age and did not correlate with fluid abilities, while ratio RT and the accuracy-based measures indicated age-related decline and correlated with fluid abilities. Therefore, RT-difference scores might mask individual differences, which compromises the interpretation of previous studies using SRTT.     

Dissociable neural systems of sequence learning

Although current theories all point to distinct neural systems for sequence learning, no consensus has been reached on which factors crucially define this distinction. Dissociable judgment-linked versus motor-linked and implicit versus explicit neural systems have been proposed. This paper reviews these two distinctions, yet concludes that these traditional dichotomies prove insufficient to account for all data on sequence learning and its neural organization. Instead, a broader theoretical framework is necessary providing a more continuous means of dissociating sequence learning systems. We argue that a more recent theory, dissociating multidimensional versus unidimensional neural systems, might provide such framework, and we discuss this theory in relation to more general principles of associative learning and recent imaging findings.     

Redundant sensory information does not enhance sequence learning in the serial reaction time task

In daily life we encounter multiple sources of sensory information at any given moment. Unknown is whether such sensory redundancy in some way affects implicit learning of a sequence of events. In the current paper we explored this issue in a serial reaction time task. Our results indicate that redundant sensory information does not enhance sequence learning when all sensory information is presented at the same location (responding to the position and/or color of the stimuli; Experiment 1), even when the distinct sensory sources provide more or less similar baseline response latencies (responding to the shape and/or color of the stimuli; Experiment 2). These findings support the claim that sequence learning does not (necessarily) benefit from sensory redundancy. Moreover, transfer was observed between various sets of stimuli, indicating that learning was predominantly response-based.     

Training Motor Sequences: Effects of Speed and Accuracy Instructions

Participants practiced a fixed 3- and a fixed 6-key press sequence for 144 times each. In the speed group, they were instructed to execute their sequences fast without bothering much about errors while the accurate group was instructed to be careful and prevent errors. In the test phase, participants executed series of 3 and 6 responses (a) when all element-specific stimuli were displayed in the familiar order, (b) in response to just the familiar first stimulus, and (c) by responding to random stimuli. The speed instruction yielded stronger sequencing skill while the accuracy instruction developed stronger reaction skill.     

Effect of Practice on Effector Independence

The authors' primary purpose in the present experiment was to determine if practice changes the extent to which simple motor sequences are effector independent. Contralateral and ipsilateral effector transfers were assessed in 24 participants after 1 (200 trials) and 4 (800 trials) days of practice. The response sequence became increasingly effector dependent; the response structure and the scaling of force on the effector transfer tests were no better after 4 days of practice than after only 1 day, even though retention performance improved substantially. Those results are consistent with the notion that participants refine their movements over extended practice by exploiting the unique characteristics of the effectors. The additional practice results in a more effective movement when the same effectors are used but is of little value when different effectors are required.     

Corrigendum

Mild to moderate Parkinson's disease shows more denervation in the posterodorsal striatum and sparing of the anteroventral striatum. Dopaminergic medications can interfere with anteroventral striatum function by overdosing this relatively intact structure. The authors determined how regional striatal denervation affects medication-associated sequence learning impairment in Parkinson's disease. Eighteen Parkinson's patients performed motor sequence learning on and off levodopa. Patients underwent ¹¹C-dihydrotetrabenazine positron emission tomography scans to measure nigrostriatal denervation. Patients with more preserved putamen were more likely to exhibit levodopa-associated sequence learning impairments. Furthermore, the ratio of denervation in the anterior to posterior dorsal putamen predicted the level of learning differences on and off levodopa. These results demonstrate that the spatial pattern of nigrostriatal dopaminergic denervation predicts medication responsiveness for motor sequence learning.