The effects of HIV disease and older age on laboratory-based,naturalistic, and self-perceived symptoms of prospective memory: does retrieval cue type and delay interval matter?

There is a rising prevalence of older HIV+ adults who are at risk of deficits in higher order neurocognitive functions and associated problems in everyday functioning. The current study applied multiprocess theory to examine the effects of HIV and aging on measures of laboratory-based, naturalistic, and self-perceived symptoms of prospective memory (PM). Participants included 125 Younger (48 with HIV, age = 32 ± 4.6 years) and 189 Older (112 with HIV, age = 56 ± 4.9 years) adults. Controlling for global neurocognitive functioning, mood, and other demographics, older age and HIV had independent effects on long-delay time-based PM in the laboratory, whereas on a naturalistic PM task older HIV? adults performed better than older HIV+ adults and younger persons. In line with the naturalistic findings, older age, but not HIV, was associated with a relative sparing of self-perceived PM failures in daily life across longer delay self-cued intervals. Findings suggest that, even in relatively younger aging cohorts, the effects of HIV and older age on PM can vary across PM delay intervals by the strategic demands of the retrieval cue type, are expressed differently in the laboratory and in daily life, and are independent of other higher order neurocognitive functions (e.g., retrospective memory).     

Anxiety,depression, and health-related quality of life in aging people living with HIV compared to diabetes patients and patients with minor health conditions: a longitudinal study

HIV infection has evolved from a fatal to a treatable condition, leading to an increase in the rate of elderly People Living with HIV (PLWH). However, little is known about the psychosocial burden of elderly PLWH. Thus, the aim of this longitudinal multi-center cohort study was to investigate whether elderly PLWH experience more anxiety and depression and reduced health related quality of life (HRQOL) compared to elderly patients with other chronic conditions. PLWH were compared to diabetes patients (DM) and patients with minor health conditions (MHC), e.g. patients with hypertension or allergic conditions. All patients were over 50 years old. Anxiety and depression (HADS) as well as HRQOL (SF-36) were assessed at baseline and after 12 months. 218 PLWH, 249 DM and 254 MHC were included. At baseline, the study groups did not differ in anxiety, depression, and physical HRQOL. However, PLWH indicated lower mental HRQOL than DM and MHC patients (p = 0.001). We did not obtain any moderating effects showing a differential effect of patient characteristics on anxiety, depression, and HRQOL in the three patient groups. At follow-up, the level of anxiety, depression, and HRQOL did not change significantly. The prevalence of anxiety ranged between 27 and 35%, and that of depression between 17 and 28%. Thus, the results of our investigation tentatively suggest that the psychosocial adaptation to HIV among elderly PLWH resembles those of other chronic diseases. There may be some subtle impairments, though, as PLWH experienced lower mental HRQOL.     

Effects of aging on action-intentional programming

Background: Action-intentional programs control “when” we initiate, inhibit, continue, and stop motor actions. The purpose of this study was to learn if there are changes in the action-intentional system with healthy aging, and if these changes are asymmetrical (right versus left upper limb) or related to impaired interhemispheric communication. Methods: We administered tests of action-intention to 41 middle-aged and older adults (61.9 ± 12.3 years). Results: Regression analyses revealed that older age predicted a decrement in performance for tests of crossed motor response inhibition as well as slower motor initiation with the left hand. Conclusion: Changes in action-intention with aging appear to be related to alterations of interhemispheric communication and/or age-related right hemisphere dysfunction; however, further research is needed to identify the mechanisms for age-related changes in the brain networks that mediate action-intention.     

Sensitive performance-based assessment of everyday action in older and younger adults

Everyday function is compromised by mild cognitive changes in aging. These changes predict risk for future decline and dementia but remain poorly characterized, largely due to a scarcity of sensitive, objective measures.Twenty-seven younger adults and 25 non-demented older adults completed the Naturalistic Action Test (NAT), a performance-based measure of everyday action involving simple and complex tasks. Performance was coded for overt errors and subtle inefficiencies. Participants also completed self-report functional measures and cognitive tests. Mixed ANOVAs revealed that older adults made more subtle NAT errors with high task demands; groups did not differ in overt errors. Correlations did not reveal significant relations between self-report and NAT errors, but NAT performance was correlated with learning and recall.The NAT provides a promising tool for detecting subtle age-related changes and examining decline across levels of impairment. Self-report may lack sensitivity to subtle changes, and episodic memory changes underlie early functional disruption.     

Older adults encode more,not less: evidence for age-related attentional broadening

Previous work has shown that older adults attend to and implicitly remember more distracting information than young adults; however, it is unknown whether they show a corresponding decrease in implicit memory for targets in the presence of distracters. Using implicit memory tests, we asked whether older adults show a tradeoff in memory between targets and distracters. Here, young and older adults performed a selective attention task in which they were instructed to attend to target pictures and ignore superimposed distracter words. We measured priming for distracter words using fragment completion and for target pictures using naming time. Older adults showed greater priming for distracting words compared to young adults, but equivalent priming for target pictures. These results suggest that older adults have a broader attentional scope than young adults, encompassing both relevant and irrelevant information.     

Beliefs about age-related changes in physical functioning across the adult life span and their relationship with physical activity levels of older adults

Physical activity declines across the adult life span despite the well-established links between physical activity and health-related, psychological, cognitive, and social benefits. We contrasted the beliefs young and older adults hold about how aging affects both physical abilities and physical activity and determined whether older adults’ beliefs about physical aging relate to their engagement in physical activity. Using visual rating scales, 56 young and 49 community-dwelling older adults indicated the extent to which a typical woman or typical man aged 20–90 possesses six different physical abilities and engages in three different types of physical activity. Stereotypes of physical aging were ability- and activity-specific, and older adults endorsed more positive views than their younger peers. Stereotypical beliefs predicted older adults’ engagement in moderate-intensity activity. This study offers intriguing avenues for future research and suggests that better understanding physical aging stereotypes may contribute toward designing interventions that promote lifelong physical activity.     

Misrecollection prevents older adults from benefitting from semantic relatedness of the memoranda in associative memory

Memory for episodic associations declines in aging, ostensibly due to decreased recollection abilities. Accordingly, associative unitization - the encoding of associated items as one integrated entity - may potentially attenuate age-related associative deficits by enabling familiarity-based retrieval, which is relatively preserved in aging. To test this hypothesis, we induced bottom-up unitization by manipulating semantic relatedness between memoranda. Twenty-four young and 24 older adults studied pairs of object pictures that were either semantically related or unrelated. Participants subsequently discriminated between intact, recombined and new pairs. We found that semantic relatedness increased the contributions of both familiarity and recollection in young adults, but did not improve older adults' performance. Instead, they showed associative deficits, driven by increased recollection-based false recognition. This may reflect a “misrecollection” phenomenon, in which older adults make more false alarms to recombined pairs with particularly high confidence, due to poorer retrieval monitoring regarding semantically-related associative probes.     

Age,criterion flexibility,and item recognition

We examined young and older adults' ability to flexibly adapt response criterion on a recognition test when the probability that a test item had been studied was cued by test color. One word color signaled that the probability of the test item being old was 70% and a second color signaled that the probability of the test item being new was 70%. Young and older adults demonstrated similar levels of criterion shifting in response to color cues. Moreover, although both young and older adults were slowed when test-item color incorrectly predicted test-item status, the extent of slowing did not differ across age group. Putative measures of cognitive control predicted recognition accuracy but not the degree to which criterion changed with test-item color. These results suggest that adaptive criterion shifting does not tax cognitive control or, if it does require effort, may be no more onerous for older than for young adults.     

Age-related differences in affective and cognitive empathy: self-report and performance-based evidence

The correlation between age and empathy is not clear, with prior findings yielding mixed and inconsistent results. Here, we distinguished between two aspects of empathy and respectively investigated the effects of age on the affective and cognitive facets of empathy using a self-report measure (interpersonal reactivity index, IRI) and performance-based tasks (viewing films). The results showed that older adults manifested age-related deficits in both trait and state cognitive empathy, with the latter being positively associated with memory. Otherwise, the overall affective empathy increased in the elderly, but the age-related differences in affective empathy may be qualified by the valence of the film clips. Specifically, older participants showed more empathic concern (EC) and less personal distress (PD) to other people’s emotions than the younger participants for the distress film. Interestingly, for the amusing film, older participants demonstrated more EC and PD. Overall, the two aspects of empathy have different development trajectories.     

Age-related differences in effectiveness of item restudy choices: the role of value

We examined the effect of value on effectiveness of restudy choices in younger and older adults by using an honor or dishonor procedure. In the honor condition, participants restudied the half of the items that they selected for restudy. In the dishonor condition, participants restudied the half of the items that they did not select for restudy. The results showed that younger adults restudied more low-value (1-point) items that they had rated as least-well learned, while older adults restudied more high-value (5-point) items. For younger adults, 1-point-value item performance in the honor condition was reliably higher than it was in the dishonor condition. For older adults, 5-point-value items performance in the honor condition was reliably higher than it was in the dishonor condition. These results suggest that older adults can exert effective restudy choices like younger adults when item value is manipulated.