Neuronal changes in normal human aging and Alzheimer's disease

This article discusses age-related changes in brain weight, total number of cortical neurons, cortical dendrites, spine, and synapse density. The conclusion is that the present outlook is less grim than it was 30 years ago. Age-related reduction appears to be specific to brain region and cortical layer rather than a general feature. In addition, we describe a different pattern of changes that occur in Alzheimer's disease patients. This review concludes that the association cortices in particular are affected in aging and Alzheimer's disease and that the primary visual and somatosensory cortices are relatively spared.     

Lapses of intention and performance variability reveal age-related increases in fluctuations of executive control

We examine the hypothesis that the efficiency of executive control processes is less stable over time in older than younger adults. An age-related decrease in the efficiency of executive control should result in an increase in performance variability in task conditions requiring the recruitment of executive control processes and not in task conditions requiring minimal involvement of executive control. Performance variability was similar for younger and older adults in task conditions requiring minimal executive control and greater for older than younger adults in task conditions requiring executive control. These and other data are consistent with the proposal that aging is associated with a decrease in the stability of executive control over time.     

Longing for Life Extension: Science Fiction and Late Life

Rejuvenescence has long been a topic of legend and medicine. As the body became the property of medical science, speculative fiction asked how fantastic experiments with bodies would affect the life course. In science fiction, medical breakthroughs promise or threaten to forestall or even reverse the decline from midlife through old age to senility and decrepitude. Responding to debates over evolution, eugenics, and scientific experimentation with human and animal subjects, rejuvenescence novels such as Bruce Sterling's Holy Fire (1996) ask readers whether they desire long life or heightened quality of life; the consolations of age or the hungers of youth; short-lived intensity or perpetual ennui.     

Postmodernism Versus Modernism: Rethinking Theoretical Tensions in Social Gerontology

The interconnection of social theory to social aspects of aging has grown in recent years. The theoretical movement entitled structured dependency, couched in social class analysis, has tended to ignore an understanding of aging identity, the body, cultural representations of aging, and positive images of aging, all of which are central features of an emerging postmodern paradigm in gerontological theory. This article argues that the concept of gender can form a useful bridge, a continuity, between structured dependency and postmodernism in theoretical gerontology. Unfortunately, the compartmentalization of these two conceptual approaches has made their links difficult to forge. This article attempts to take a first step in this direction by highlighting the way postmodern ideas can be used to understand a modernist issue—gender in a gerontological context. Also, focusing on the aging body as a primary form of analysis generates some novel insights into the importance of both the theoretical understanding and cultural representations of the body.     

The Late Life Reconstruction of Selfhood Analyzed in Peter Hall's Film She's Been Away

The film She's Been Away tells the story of an old woman who had been locked in a mental asylum while a teenager, for willfully violating repressive sexual codes. Sixty years later her ward is closed and she moves in with her nephew and his wife. Faced with what appears to be a hopeless situation, she manages to forge a sense of a meaningful closure to a misspent life. Through narrative, story structure, and characterization the film throws into focus coping mechanisms and ego strategies deployed by a triple disadvantaged person (woman, old, and mad) in her ascent to a reconstructed selfhood. As the protagonist ties both ends of her life, and faces the abyss in between she makes genuine adaptive use of so-called regressive, late-life development assets (available to a lesser degree to elderly people in normal life circumstances), primarily the abolition of linear time. Through this abolition she makes reminiscing an actual reality while still maintaining a functional separation between the real and the remembered. Her portrayal is a valuable document for gerontologists as it explores, through artistic imagination and intuition, the workings of an aging mind in search for a meaningful sense of closure.     

Development Towards Wisdom and Maturity: Sufi Conception of Self

By applying results from in-depth interviews with older Iranian Sufis residing in Sweden, this article describes the benefits of the value system of Sufism prizing mystical union above self-realization. As persons conceive of themselves as all forming parts of other-than-self rather than as separate selves, the result is tolerance towards other people's opinions and the vanishing of hostile feelings and competition. Compassion and identification with the whole of creation allows Sufis to avoid the sense of loneliness and exclusion felt by so many immigrants.     

Sex differences and estropausal phase effects on water maze performance in aged rats

An age-related decline in memory has been reported in male rats; however, there are few studies that have addressed these changes in aged female rats. In young female rats, hormonal cycles influence behavior. By the age of 22 months most female rats have not had regular hormonal cycles for at least 9 months. In the current study we examined how the hormonal status (persistent estrus and pseudo-pregnant) of the aged (22-24 months) female rat (Long Evans) influenced performance on a spatial version of the Morris water maze and compared this to aged male rats. Aged females in persistent estrus showed better performance on the water maze than both aged females that were pseudopregnant and aged males. Thus, postestropausal hormonal status may influence the course of aging in females.     

The Beck Anxiety Inventory in Older Adults With Generalized Anxiety Disorder

The authors investigated the psychometric properties of the Beck Anxiety Inventory (BAI) in a sample of 75 older generalized anxiety disorder (GAD) patients and a comparison group of 32 older adults without significant psychopathology. Internal consistency was above .80, and the BAI showed evidence of convergent validity in both groups. Evidence for discriminant validity with respect to measures of depression was weaker. Two items, fearing the worst and nervousness, correctly distinguished 86.5% of patients with GAD and 93.8% of the normal controls. Medical comorbidity was associated with somatic but not cognitive anxiety symptoms in the normal older sample. Overall, results indicate the limitations of the BAI in assessing anxiety symptoms in older adults and suggest the need for use of an instrument focusing on cognitive aspects of anxiety.     

An evidential support accumulation model of subjective probability

A model of cue-based probability judgment is developed within the framework of support theory. Cue diagnosticity is evaluated from experience as represented by error-free frequency counts. When presented with a pattern of cues, the diagnostic implications of each cue are assessed independently and then summed to arrive at an assessment of the support for a hypothesis, with greater weight placed on present than on absent cues. The model can also accommodate adjustment of support in light of the baserate or prior probability of a hypothesis. Support for alternatives packed together in a "residual" hypothesis is discounted; fewer cues are consulted in assessing support for alternatives as support for the focal hypothesis increases. Results of fitting this and several alternative models to data from four new multiple-cue probability learning experiments are reported.     

Bertrand Russell in His Nineties: Aging and the Problem of Biography

Bertrand Russell, one of the twentieth century's leading philosophers, lived to be ninety-eight, spending his last decade as a vigorous and often unpopular political activist. His generally sympathetic biographers tend to view this last decade through the prism of senility, but the only justification for this judgment would appear to be the objective fact of Russell's age. Almost identical behaviors from his younger years are never attributed to mental shortcomings. The treatment of Russell suggests that biographers are susceptible to powerful, distorting, and fictive predispositions as they shape their subjects' later years.