基于机体反馈调控保护扭转肿瘤治疗思路

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Do people treat missing information adaptively when making inferences?

When making inferences, people are often confronted with situations with incomplete information. Previous research has led to a mixed picture about how people react to missing information. Options include ignoring missing information, treating it as either positive or negative, using the average of past observations for replacement, or using the most frequent observation of the available information as a placeholder. The accuracy of these inference mechanisms depends on characteristics of the environment. When missing information is uniformly distributed, it is most accurate to treat it as the average, whereas when it is negatively correlated with the criterion to be judged, treating missing information as if it were negative is most accurate. Whether people treat missing information adaptively according to the environment was tested in two studies. The results show that participants were sensitive to how missing information was distributed in an environment and most frequently selected the mechanism that was most adaptive. From these results the authors conclude that reacting to missing information in different ways is an adaptive response to environmental characteristics.     

Interest as a Motivational Resource: Feedback and Gender Matter, but Interest Makes the Difference

This study tested the hypothesis that interest in a certain topic enables children to sustain their intrinsic motivation in topic-related tasks when positive feedback is absent. Ninety-one Israeli children in the seventh grade completed a questionnaire assessing their interest in the topic of logic questions. Later, in individual sessions, children worked on logic questions, and either received positive feedback or no feedback on their performance. Then, they completed a questionnaire assessing their intrinsic motivation to participate in a similar task. As expected, children with a high level of interest reported more intrinsic motivation than did children not high on interest. Among children with moderate interest, absence of positive feedback was associated with decreased intrinsic motivation for boys, and increased motivation for girls. This gender-related pattern was interpreted as suggesting that girls with moderate interest perceived the positive feedback as an attempt to control them. The findings support the view that interest may serve as a personal resource that helps children to cope with non-optimal learning conditions.     

Emotional and motivational reactions to failure: the role of illusions of control and explicitness of feedback

Previous research has found that illusions of control (IOC) can buffer against the emotional consequences of failure and may increase persistence in the face of failure. Theoretical analyses suggest that IOC are most closely related to a better mood and higher motivation if failure feedback is open to reinterpretation. Two experiments were conducted to test the hypothesis that explicitness (vs. ambiguousness) of failure feedback moderates the consequences of IOC following a failure experience. In accord with predictions, it was found that IOC were subsequently related to a better mood (Study 1) and higher persistence (Study 2) if individuals received ambiguous task-inherent failure feedback. In contrast, explicit failure feedback seemed to neutralize the beneficial effects of IOC. These results are discussed with respect to the adaptiveness of IOC.

Feedback related brain activity in a gambling task: A temporal analysis of EEG correlates

Lucchiari, C. & Pravettoni, G. (2010). Feedback related brain activity in a gambling task: A temporal analysis of EEG correlates. Scandinavian Journal of Psychology 51, 449–454. The pattern of neural correlates of feedback processing has been the subject of a number of studies, using both neuroimaging and electrophysiological recordings. A complex functional network was found to be activated after a choice in order to process a feedback and sustain an adaptive behavior. However, many aspects of this network are still unclear and further research is needed to better understand this process. We conducted an EEG study using a simple gambling task. Twenty three subjects participated to the study. We analyzed both EEG power spectrum and ERP components evoked by presentation of a feedback signal (money gain or loss) during a simple gambling task. Our data confirmed that a negative ERP component is present about 270 ms after feedback, particularly relevant following a choice with negative outcome. Furthermore, the theta and delta oscillatory activity seem to be correlated to a dynamic decision‐making process within specific cortical networks. In particular, theta activity showed a valence dependent development between 150 and 350 ms post‐feedback onset. Differently from previous studies (Cohen, Elger & Ranganath, 2007; Marco‐Pallares, Cucurell, Cunillera et al., 2008), we did not find any valence effect in beta range. However, our data are consistent with Christie and Tata (2009) , probably due to the nature of the gambling task used in both studies. In conclusion, our data, in line with some prior findings showed that the feedback related response is correlated to a complex pattern of cortical activation probably mediated by theta and delta activity.     

Perceptual strength is different from sensorimotor strength: Evidence from the centre–periphery asymmetry in masked priming

Near-threshold prime stimuli can facilitate or hinder responses to target stimuli, creating either a positive compatibility effect (PCE) or a negative compatibility effect (NCE). An asymmetry has been reported between primes presented in near periphery, which produced a PCE, and foveal primes, which produced an NCE under comparable conditions. This asymmetry has been attributed to the difference in retinal sensitivity, but it remains unclear whether this means that equating discrimination performance for primes in fovea and periphery, in order to account for differences in perceptual sensitivity, would make the priming effects the same. Wider work indicates that perceptual ability can dissociate from visuomotor effects, predicting that equating perceptual ability for fovea and periphery would not equate priming. We tested these opposite possibilities by matching discrimination performance for masked Gabor patches in fovea and near periphery (6°) and using these as primes in a masked priming paradigm expected to elicit NCEs. We found the asymmetry remained: NCE for fovea and PCE for periphery. We replicated this with both blocked and randomized procedures to check for attentional effects. We conclude that equating perceptual strength (discriminability) of stimuli does not equate their sensorimotor impact due to differences in the relative importance of different visual pathways and differing temporal dynamics in perceptual and sensorimotor processes.     

Intentional Teaching Facilitates Young Children's Comprehension and Use of a Symbolic Object

Children are exposed to symbolic objects that they have to learn to use very early in life. The authors’ aim was to examine whether it is possible to intentionally teach young children the symbolic function of an object. They employed a search task in which children had to use a map to find a toy. Experiment 1 revealed that with no instruction 3-year-, 10-month-old children were quite successful; 3-year-, 6-month-olds showed a divided performance; and 3-year-, 0-month-olds failed. With this baseline, Experiment 2 compared the performance of 3-year-, 0-month-olds in three different conditions: no-instruction, complete instruction (before the task begins), and teaching (complete instruction plus corrective feedback); only children in the teaching condition succeeded. However, children 6 months younger, 2-year-, 6-month-olds, failed despite teaching that was provided (Study 3). This research shows that at some points in development instruction is not enough; intentional teaching in communicative contexts is the mechanism that boosts symbolic understanding in early childhood.     

Knowledge of Results for Motor Learning: Relationship Between Error Estimation and Knowledge of Results Frequency

The authors of the present study investigated the apparent contradiction between early and more recent views of knowledge of results (KR), the idea that how one is engaged before receiving KR may not be independent of how one uses that KR. In a 2 × 2 factorial design, participants (N = 64) practiced a simple force-production task and (a) were required, or not required, to estimate error about their previous response and (b) were provided KR either after every response (100%) or after every 5th response (20%) during acquisition. A no-KR retention test revealed an interaction between acquisition error estimation and KR frequencies. The group that received 100% KR and was required to error estimate during acquisition performed the best during retention. The 2 groups that received 20% KR performed less well. Finally, the group that received 100% KR and was not required to error estimate during acquisition performed the poorest during retention. One general interpretation of that pattern of results is that motor learning is an increasing function of the degree to which participants use KR to test response hypotheses (J. A. Adams, 1971; R. A. Schmidt, 1975). Practicing simple responses coupled with error estimation may embody response hypotheses that can be tested with KR, thus benefiting motor learning most under a 100% KR condition. Practicing simple responses without error estimation is less likely to embody response hypothesis, however, which may increase the probability that participants will use KR to guide upcoming responses, thus attenuating motor learning under a 100% KR condition. The authors conclude, therefore, that how one is engaged before receiving KR may not be independent of how one uses KR.     

Modulating younger and older adults’ performance in ignoring pictorial information during a word matching task

Using both behavioural and event-related potential (ERP) data, the current study sought to examine the neurophysiological underpinnings for the effect of distracting pictorial information on semantic word matching performance in younger and older adults. This was tested in the context of semantic relations between task-relevant word pairs, a task-irrelevant picture and the resultant N400 differences in ERP. Younger and older adults were shown a context word superimposed on a to-be-ignored picture, followed by a test word. Their task was to determine whether the prime and test words were semantically related. The to-be-ignored pictures were interfering (for ‘No’ trials), facilitating (for ‘Yes’ trials), or neutral (for both ‘Yes’ and ‘No’ trials) to the expected responses. The interfering and facilitatory effects of to-be-ignored pictures were assessed under more automatic and more controlled conditions by manipulating the context–test interstimulus-interval (ISI) as 50 ms and 1000 ms, respectively. The analysis of the N400 at centro-parietal sites during test word display revealed similar N400 amplitudes for the ‘No’ response trials at the two ISIs, suggesting that younger and older adults showed an equivalent effect from interfering pictures. In contrast, younger adults showed greater reductions in the N400, as compared to older adults, for ‘Yes’ trials indicating differential effects in facilitation from to-be-ignored pictorial information, but only in the long ISI condition. The data are discussed in terms of age differences in resource demanding strategy use during a semantic word matching task, specifically during controlled retrieval.