基于机体反馈调控保护扭转肿瘤治疗思路

肿瘤的临床治疗经过漫长积极探索研究,中西医疗效均未取得成就性突破,本文穿越时空隧道,基于人类亿万年适应环境生存生物进化历程形成的精细反馈调控保护视角,循证机体实施反馈调控保护顽强延续生命依据,结合肿瘤病理生理机制,剖析肿瘤形成原因,追溯肿瘤临床治疗误区,扭转肿瘤治疗思路,引领肿瘤治疗新路径。     

拓广分部评分模型下计算机自适应测验变加权选题策略

摘要: 在计算机自适应测验中, 对0-1评分模型按a-分层选题是高效安全的策略,但多级评分模型的项目难度/步骤参数有多个而无法直接应用这种选题策略。信息函数能够很好地综合项目所有参数及能力参数,但最大信息量选题策略会影响考试安全。本文提出一种变加权选题策略,它通过调用一个与信息量相关联的函数,该函数与信息量成正比,与区分度的某个幂函数成反比,从而达到既能综合项目所有参数又按a分层的效果。在GPCM模型下用蒙特卡罗实验进行比较研究,结果显示新的选题策略总体效果比已有相关结果好。     

Effects of unit formation on the perception of a changing sound

The effects of subunit formation on adult listeners' ability to notice changes in a continuous spectral gradient of sound were studied. Results of this experiment support the idea that the auditory system processes information differently within a unit, and that this processing does not occur unless the perceptual system detects unit boundaries. In this experiment, silences were inserted into a continuously changing sound to cause the formation of short units. Listeners noticed the change earlier in conditions with silences inserted than in to conditions where the transition was either unbroken or broken by loud noise bursts. Results are discussed in terms of two processes, one that accentuates stimulus properties present at moments of onset and offset, and a second that uses onsets and offsets to signal the beginnings and ends of units and reduces the change perceived within units.     

Do people treat missing information adaptively when making inferences?

When making inferences, people are often confronted with situations with incomplete information. Previous research has led to a mixed picture about how people react to missing information. Options include ignoring missing information, treating it as either positive or negative, using the average of past observations for replacement, or using the most frequent observation of the available information as a placeholder. The accuracy of these inference mechanisms depends on characteristics of the environment. When missing information is uniformly distributed, it is most accurate to treat it as the average, whereas when it is negatively correlated with the criterion to be judged, treating missing information as if it were negative is most accurate. Whether people treat missing information adaptively according to the environment was tested in two studies. The results show that participants were sensitive to how missing information was distributed in an environment and most frequently selected the mechanism that was most adaptive. From these results the authors conclude that reacting to missing information in different ways is an adaptive response to environmental characteristics.     

Whichever way you choose to categorize,working memory helps you learn

There has been growing interest in the relationship between the capacity of a person's working memory and their ability to learn to categorize stimuli. While there is evidence that working memory capacity (WMC) is related to the speed of category learning, it is unknown whether WMC predicts which strategies people use when there are multiple possible solutions to a categorization problem. To explore the relationship between WMC, category learning, and categorization strategy use, 173 participants completed two categorization tasks and a battery of WMC tasks. WMC predicted the speed of category learning, but it did not predict which strategies participants chose to perform categorization. Thus, WMC does not predict which categorization strategies people use but it predicts how well they will use the strategy they select.     

Perceptual strength is different from sensorimotor strength: Evidence from the centre–periphery asymmetry in masked priming

Near-threshold prime stimuli can facilitate or hinder responses to target stimuli, creating either a positive compatibility effect (PCE) or a negative compatibility effect (NCE). An asymmetry has been reported between primes presented in near periphery, which produced a PCE, and foveal primes, which produced an NCE under comparable conditions. This asymmetry has been attributed to the difference in retinal sensitivity, but it remains unclear whether this means that equating discrimination performance for primes in fovea and periphery, in order to account for differences in perceptual sensitivity, would make the priming effects the same. Wider work indicates that perceptual ability can dissociate from visuomotor effects, predicting that equating perceptual ability for fovea and periphery would not equate priming. We tested these opposite possibilities by matching discrimination performance for masked Gabor patches in fovea and near periphery (6°) and using these as primes in a masked priming paradigm expected to elicit NCEs. We found the asymmetry remained: NCE for fovea and PCE for periphery. We replicated this with both blocked and randomized procedures to check for attentional effects. We conclude that equating perceptual strength (discriminability) of stimuli does not equate their sensorimotor impact due to differences in the relative importance of different visual pathways and differing temporal dynamics in perceptual and sensorimotor processes.     

Instruction and load effects on high-skill and low-skill individuals: A study in the domain of mental arithmetic

What happens when people are asked to respond as quickly or as accurately as possible? This study tested the effects of speed/accuracy instructions and working-memory load on people's strategy efficiency and strategy selection. Adult participants solved simple addition problems (Experiment 1) and simple multiplication problems (Experiment 2) under load and no-load conditions and provided trial-by-trial strategy reports. High-skill participants were more efficient than low-skill participants, but the underlying causes of these skill-related effects differed across experiments. In the addition experiment, high-skill participants responded adaptively to the changing situations by changing their strategy choices, which resulted in smaller effects on their actual performance. Low-skill participants in contrast, did not change their strategy choices as adaptively, which resulted in less efficient performance—and especially so under load conditions. In the multiplication experiment, high-skill and low-skill participants differed in strategy efficiencies rather than in strategy choices. In the discussion, the results are further interpreted and future adaptations for the adaptive strategy choice model (ASCM; Siegler & Jenkins, 1989) are suggested.     

Effects of execution duration on within-item strategy switching in young and older adults

This study aimed at determining whether previously found age-related differences in within-item strategy switching is modulated by duration of engagement in initial strategy execution. In a computational estimation task, young and older adults had to find estimates to arithmetic problems like 37×64 while either rounding down (i.e., 30×60) or rounding up (i.e., 40×70) both operands to the closest decades. Participants were asked to execute a cued strategy for different durations (i.e., 1, 2, or 3 s), before deciding whether the cued strategy was the best strategy and to switch to the best strategy if the cued strategy was not the best. The main findings revealed that (1) young and older adults were able to switch strategies, especially when they started to execute poorer strategy on a given item; (2) older adults switched strategy less often than young adults, and (3) both young and older participants switched strategy less frequently for long than for short durations. These findings suggest that to be able to switch strategy within item, participants should not be too much engaged in execution of the initially selected strategy, and that duration of engagement in initial strategy execution does not modulate age-related differences in within-item strategy execution.     

Human performance on negative slope schedules of points exchangeable for money: a failure of molar maximization

Panel pressing was generated and maintained in 5 adult humans by schedules of points exchangeable for money. Following exposure to a variable-interval 30-s schedule and to a linear variable-interval 30-s schedule (which permitted points to accumulate in an unseen "store" in the absence of responding), subjects were exposed to a series of conditions with a point-subtraction contingency arranged conjointly with the linear variable-interval schedule. Specifically, points were added to the store according to the linear-variable interval 30-s schedule and were subtracted from the store according to a ratio schedule. Ratio value varied across conditions and was determined individually for each subject such that the subtraction contingency would result in an approximately 50% reduction in the rate of point delivery. Conditions that included the subtraction contingency were termed negative slope schedules because the feedback functions were negatively sloped across all response rates greater than the inverse of the variable-interval schedule, in this case, two per minute. Overall response rates varied inversely with the subtraction ratio, indicating sensitivity to the negative slope conditions, but were in excess of that required by accounts based on strict maximization of overall reinforcement rate. Performance was also not well described by a matching-based account. Detailed analyses of response patterning revealed a consistent two-state pattern in which bursts of high-rate responding alternated with periods of prolonged pausing, perhaps reflecting the joint influence of local and overall reinforcement rates.     

Interpreting the uninterpretable: The effect of self-esteem on the interpretation of meaningless feedback

People often seek out and retain positive information about themselves via self-enhancement processes. Under other circumstances, they seek out and retain self-confirmatory information via self-verification processes. Research on both of these self-evaluation processes has been based heavily on domains such as social skills, in which people have a large database of prior information that presumably influences the way in which incoming self-relevant information is interpreted. In the present research, participants were asked to evaluate themselves on a set of imaginary "pseudotraits" to investigate how self-esteem influences the self-evaluation process when prior information is unavailable. Participants who had been identified through pre-testing as either high or low in self-esteem received false feedback on five pseudotraits (e.g., "casortic"), after which they evaluated the favorability of this feedback. High self-esteem participants tended to view their feedback as favorable, whereas low self-esteem participants did not.