Hemispheric specialization for emotional word processing is a function of SSRI responsiveness

Vulnerability to depression and non-response to Selective Serotonin Reuptake Inhibitors (SSRIs) are associated with specific neurophysiological characteristics including greater right hemisphere (RH) relative to left hemisphere (LH) activity. The present study investigated the relationship between hemispheric specialization and processing of emotional words using a divided visual field paradigm administered to never-depressed and previously-depressed individuals, who were subdivided into SSRI responders and non-responders. SSRI responders and never-depressed participants were similar in their left hemispheric lateralization for evaluating emotional words. In contrast, SSRI non-responders showed a relative shift towards RH processing of negative words, and a strong bias toward negative evaluation of words presented to the RH. The results are discussed within the context of a biological-cognitive model of vulnerability to depression.     

Consciousness wanted,attention found: Reasons for the advantage of the left visual field in identifying T2 among rapidly presented series

Everyday experience suggests that people are equally aware of events in both hemi-fields. However, when two streams of stimuli are rapidly presented left and right containing two targets, the second target is better identified in the left than in the right visual field.This might be considered evidence for a right-hemisphere advantage in generating conscious percepts. However, this putative asymmetry of conscious perception cannot be measured independently of participants’ access to their conscious percepts, and there is actually evidence from split-brain patients for the reverse, left-hemisphere advantage in having access to conscious percepts. Several other topics were studied in search of the responsible mechanism, among others: Mutual inhibition of hemispheres, cooperation of hemispheres in perceiving midline stimuli, and asymmetries in processing various perceptual inputs. Directing attention by salient cues turned out to be one of the few mechanisms capable of modifying the left visual-field advantage in this paradigm. Thus, this left visual-field advantage is best explained by the notion of a right-hemisphere advantage in directing attention to salient events. Dovetailing with the pathological asymmetries of attention after right-hemisphere lesions and with asymmetries of brain activation when healthy participants shift their attention, the present results extend that body of evidence by demonstrating unusually large and reliable behavioral asymmetries for attention-directing processes in healthy participants.     

Validity and reliability of electroencephalographic frontal alpha asymmetry and frontal midline theta as biomarkers for depression

Electroencephalographic (EEG) frontal alpha asymmetry (FAA) and frontal midline (FM) theta have been suggested as biomarkers for depression and anxiety, but have mostly been assessed in small and non‐clinical studies. In a clinical sample of 79 adults with depression (ICD‐10: F32), resting EEG and scales of depression (MADRS) and anxiety (HADS‐A) were measured at intake and after 3 months. FAA and FM theta values were referenced to a normative population database. Internal consistency, test‐retest reliability, and correlations with psychiatric tests were examined. Reliability was sufficient. However, FAA and FM theta values were close to the general population, and correlations with psychiatric tests were mostly small and non‐significant, with the exception of FAA on F7–F8 z‐scores and HADS‐A. We conclude that the validity of FAA and FM theta and therefore their potential as biomarkers for depression and anxiety remain unclear.     

Asymmetry and performance: toward a neurodevelopmental theory

Hemispheric asymmetry implies the existence of developmental influences that affect one hemisphere more than the other. However, those influences are poorly understood. One simple view is that asymmetry may exist because of a relationship between a mental process' degree of lateralization and how well it functions. Data scaling issues have largely prevented such investigations, but it is shown that scaling effects are minimized after correction for ceiling and floor effects. After correction, lateralization-performance correlations are pervasive. However, while some correlations are positive, others are negative, with the direction depending on the underlying lateralized process. Two hypotheses are proposed that can account for these relationships by pointing either to individual differences in maturation of the corpus callosum or to developmental limits encountered at different ages of childhood. Their investigation should contribute toward a neurodevelopmental theory of hemispheric asymmetry.     

Is a sigh “just a sigh”? Sighs as emotional signals and responses to a difficult task

Sighing and the interpretation of sighs in everyday life seem never to have been the subject of psychological research. A questionnaire study of sighing showed that people associate sighing mainly with negative, low-intensity and deactivated emotional states. A second study investigated self/other differences in the interpretation of sighs in four hypothetical situations, revealing that sighs in other people are primarily perceived as signs of sadness, whereas own sighs are more often believed to express a state of "giving up" something or somebody. In a third experimental study participants worked on difficult (insoluble) puzzles, which generated many futile solution attempts, often accompanied by sighs. It is concluded that sighs are often unintentional expressions of an activity, plan or desire that has to be discarded, creating a pause before it can be replaced by a novel initiative.     

主、宾关系从句加工不对称性效应及其神经机制

句子加工领域内, 主、宾关系从句加工不对称性效应是诸多语种内普遍存在的一种语言现象。本文对主、宾关系从句加工不对称性效应从如下几个方面进行了分析和论述：①从成人语言、儿童语言和失语症患者三个领域并结合印欧语系和非印欧语系的语言特征, 详细分析了该效应及其普遍性和特殊性; ②主、宾关系从句加工不对称性效应的理论解释：句法角色理论、“填充语-空位”依附理论、积极填充策略、名词短语可及性层级理论和干扰相似性理论; ③与主、宾关系从句加工不对称性效应有关的脑电成分及相应的脑区激活模式的分析。最后, 在对已有理论评价分析的基础上, 提出“标记浮动”句子加工理论模型, 并指出该领域未来的研究方向。     

多身份追踪中基于表情特征的分组效应

探讨了表情因素作为身份特征对多身份追踪中分组效应的影响。采用多身份追踪范式, 8个客体为表情图片(正性、负性、中性)其中4个为目标, 对45名被试进行了有无眉毛线索对追踪表现影响的测查。实验条件分别为：目标表情与非目标表情完全不相同组(4水平, 简称分组)、目标表情与非目标表情都由两种相同数量的表情混合组成(3水平, 简称配对)与基线组(8个客体表情相同)。发现分组水平的成绩显著优于基线组, 配对水平的成绩显著低于基线组, 并表现出了负性表情的追踪优势; 另外, 有无眉毛线索对追踪表现无显著影响。这一结果说明多身份追踪中存在基于表情特征的分组效应, 负性表情的分组知觉高于正性表情。     

How does reading direction modulate perceptual asymmetry effects?

Left-side bias effects refer to a bias towards the left side of the stimulus/space in perceptual/visuospatial judgments, and are argued to reflect dominance of right hemisphere processing. It remains unclear whether reading direction can also account for the bias effect. Previous studies comparing readers of languages read from left to right with those read from right to left (e.g., French vs. Hebrew) have obtained inconsistent results. As a language that can be read from left to right or from right to left, Chinese provides a unique opportunity for a within-culture examination of reading direction effects. Chinese participants performed a perceptual judgment task (with both face and Chinese character stimuli; Experiment 1) and two visuospatial attention tasks (the greyscales and line bisection tasks; Experiment 2) once before and once after a reading task, in which they read Chinese passages either from left to right or from right to left for about 20 min. After reading from right to left, participants showed significantly reduced left-side bias in Chinese character perceptual judgments but not in the other three tasks. This effect suggests that the role of reading direction on different forms of left-side bias may differ, and its modulation may be stimulus-specific.     

The advantage of mentally rotating clockwise

The time taken to decide whether a character is shown in its mirror or normal version has been shown to increase approximately linearly with the angular departure from an up-right position. Additionally, in some studies, decisions took longer for clockwise tilted characters than for counterclockwise tilted ones. Other studies do not report the latter effect. We argue that inconsistencies across studies are caused by variance in participants' strategies. The task employed here was specifically designed to bring these strategies and thereby the direction of rotation under experimental control. From the EEG recorded during the rotation period, we extracted an event-related slow potential whose amplitude is sensitive to the amount of mental rotation. In both strategy conditions, the slow potential's amplitude was lower for clockwise than for counterclockwise rotations. We take this as evidence that mental rotation of alphanumeric characters is easier in a clockwise than in a counterclockwise direction.     

Fifty years of dichotic listening research - still going and going and…

This year celebrates 50 years of research in auditory laterality and hemispheric asymmetry, using a dichotic listening approach. The discovery of the "right ear advantage" in 1961 by Doreen Kimura to dichotic presentations of phonetic stimuli paved the way for new studies of how speech perception and related language processes are lateralized in the human brain. The articles in this special issue, celebrating the first 50 years of dichotic listening research, reveal both the breadth and depth of current research, with contributions spanning from basic research to clinical applications, from behavioral studies to studies using advanced neuroimaging techniques, and with contributions from all over the world. It is my hope as Guest Editor that the next 50 years will be as productive as the first 50 years.