Right hemisphere semantic processing of visual words in an aphasic patient: an fMRI study

This study was designed to identify the neural network supporting the semantic processing of visual words in a patient with large-scale damage to left-hemisphere (LH) language structures. Patient GP, and a control subject, RT, performed semantic and orthographic tasks while brain-activation patterns were recorded using functional magnetic resonance imaging. In RT, the semantic-orthographic comparison activated LH perisylvian and extrasylvian temporal regions comparable to the network of areas activated by non-brain-damaged subjects in other neuroimaging studies of semantic discrimination. In GP, the same comparison activated homologous right-hemisphere regions, demonstrating the ability of the right hemisphere to subserve visual lexicosemantic processes. The results are discussed within the context of the normal right hemisphere's capacity for semantic processing of visual words. Examining results from functional neuroimaging studies on recovery in the context of innate hemispheric abilities may enable reconciliation of disparate claims about mechanisms supporting recovery from aphasia.     

The role of phonological activation in the visual semantic retrieval of Chinese characters

The Stroop paradigm was used to examine the role of phonological activation in semantic access and its development in reading Chinese characters. Subjects (age 7-23 years) of different reading ability were asked to name the display color of Chinese characters. The characters were displayed in four different colors: red, yellow, blue and green. There were five types of relationships between a character and its display color: semantically congruent, phonologically congruent, semantically incongruent, phonologically incongruent and neutral. In addition to the classical Stroop effects, interference and facilitation effects from the homophones of color characters were also observed. The younger children and those with lower reading ability exhibited stronger Stroop effects. These findings suggest that phonological codes are activated automatically in Chinese character recognition. Furthermore, there is more phonological activation in the semantic retrieval of children in lower grades and those with lower reading ability.     

Cognitive and Behavioral Contributions to Depression Severity,Quality of Life,and Functioning Among People Living With HIV in South Africa

Cognitive-behavioral treatments for depression typically address both behavioral (e.g., activation) and cognitive (e.g., rumination) components, and consequently improve quality of life (QOL) and function in high-resource settings. However, little is known about the cross-cultural applicability and relative contribution of these components to depression symptom severity, QOL, and functional impairment in South Africa and other resource-limited global settings with high HIV prevalence rates.Persons with HIV (N = 274) from a peri-urban community outside Cape Town, South Africa, were administered multiple measures of depression (Hamilton Depression Scale, Centre for Epidemiological Studies Depression Scale, South African Depression Scale), cognitive and behavioral components related to depression (Ruminative Response Scale, Behavioral Activation for Depression Scale), and measures of QOL and functioning (Sheehan Disability Scale, Quality of Life Enjoyment and Satisfaction Scale—Short Form). Multiple linear regression models were fit to assess the relative contribution of behavioral and cognitive components to depression severity, QOL, and functional impairment in this population.Models accounting for age and sex revealed that lower levels of behavioral activation (BA) were significantly associated with all measures of depression, as well as with QOL and functional impairment (all ps < .01). Rumination was associated with all measures of depression (all ps < .01), but not with QOL or functional impairment.The consistent and unique association of BA with depression, QOL, and functional impairment bolsters its importance as a treatment target for this population.     

连绵词语音类似的启动效应

研究采用快速启动范型考察了视觉连绵词加工中语音的自动激活.两个实验发现,无论是首字同音还是尾字同音启动都可以促进对连绵词的命名反应,且基本不受目标词熟悉性(词频高低)及真假词的影响.可以推断,至少在连绵词--这种单词素词的词汇通达中存在语音的自动激活,这种语音的激活可以说是前词的装配与词水平上的改变.     

Eighteen-month-olds integrate verbal cues into their action processing: Evidence from ERPs and mu power

Behavioral research has shown that infants use both behavioral cues and verbal cues when processing the goals of others’ actions. For instance, 18-month-olds selectively imitate an observed goal-directed action depending on its (in)congruence with a model’s previous verbal announcement of a desired action goal. This EEG-study analyzed the electrophysiological underpinnings of these behavioral findings on the two functional levels of conceptual action processing and motor activation. Mid-latency mean negative ERP amplitude and mu-frequency band power were analyzed while 18-month-olds (N = 38) watched videos of an adult who performed one out of two potential actions on a novel object. In a within-subjects design, the action demonstration was preceded by either a congruent or an incongruent verbally announced action goal (e.g., “up” or “down” and upward movement). Overall, ERP negativity did not differ between conditions, but a closer inspection revealed that in two subgroups, about half of the infants showed a broadly distributed increased mid-latency ERP negativity (indicating enhanced conceptual action processing) for either the congruent or the incongruent stimuli, respectively. As expected, mu power at sensorimotor sites was reduced (indicating enhanced motor activation) for congruent relative to incongruent stimuli in the entire sample. Both EEG correlates were related to infants’ language skills. Hence, 18-month-olds integrate action-goal-related verbal cues into their processing of others’ actions, at the functional levels of both conceptual processing and motor activation. Further, cue integration when inferring others’ action goals is related to infants’ language proficiency.     

时间的多维度空间表征:分离的起源与激活机制

近期研究发现时间可以分别在三个空间维度(左右、前后和上下)进行表征, 但不同维度心理时间线的起源和激活机制尚存争议。最新证据表明, 左右维度时间线主要起源于阅读/书写习惯所伴随的感觉运动经验, 其激活可能是一种低水平的感觉运动机制; 前后和上下维度时间线主要起源于语言中的空间隐喻, 其激活可能是一种高水平的语义机制。未来研究应更关注心理时间线的起源多样性、先天基础、神经机制以及时间线和数字线的类比。     

非平衡中-英双语者言语产生中非目标语言的语音激活

采用改造的图片命名启动范式考察非平衡中-英双语者在言语产生中非目标语言的语音激活范围。实验1探讨在准备用汉语命名图片后,英语词汇的语音激活。结果发现,英语语音一致词的命名反应快于语音相关词和语音无关词,且语音相关词的命名反应快于语音无关词,说明在一语的产生过程中,二语对等词和相关词的语音都得到了激活。实验2探讨在准备用英语命名图片后,汉语词汇的语音激活。结果发现,汉语语音一致词的命名反应快于语音相关词和语音无关词,而语音相关词与语音无关词之间的命名反应没有显著差异,说明在二语的产生过程中,只有一语对等词的语音得到了激活。总结果表明,非平衡中-英双语者使用目标语言时,非目标语言的语音也可以得到激活,并且激活范围可能受非目标语言熟练水平的影响。     

Hemisphere Specialization as an Aid in Early Infancy

In order that different directions of attention can be organized, they have to be labeled and assessed. A statement of a general problem can be regarded as a label for a general direction of attention. Hope about it, as the perceived probability of sufficient success, on the basis of work done, can be regarded as an assessment. It can be argued that a young infant meets an impasse arising from the work on 2 incompatible general problems, (1) that of raising hope of certainty about the environment (linked to the arousal system because repeated stimulation has less effect), and (2) that of raising hope of producing effects (linked to the activation system because here some effect must be produced before activity can cease). A certainty–right hypothesis, that the right hemisphere deals with the certainty problem and the left deals with the producing-effects problem, and hence keeps work on the two problems apart in early infancy while the corpus callosum is undeveloped, and that a matching specialization continues in later life, is supported.     

Responsiveness to Threat and Incentive in Bipolar Disorder: Relations of the BIS/BAS Scales with Symptoms

Over the past 10 years, theorists have suggested that bipolar disorder symptoms result from increases and decreases in the activity of the Behavioral Activation or Facilitation System (BAS or BFS) and the Behavioral Inhibition System (BIS). These neurobehavioral systems are thought to determine the intensity of affective and behavioral responses to incentives and threats. This study examined cross-sectional and prospective associations of self-reported BIS and BAS with mania and depression in a sample of 59 individuals diagnosed with Bipolar I disorder. Depression was tied to BIS, pointing to the importance of sensitivity to threats in depression. However, links between BIS and depression appeared state-dependent. BAS subscales did not correlate with manic symptoms in a state-dependent manner; however, BAS (total scale and reward responsiveness subscale) predicted relative intensification of manic symptoms over time. Thus, evidence suggests that BAS sensitivity may constitute a vulnerability to mania among persons diagnosed with bipolar disorder. Discussion focuses on the integrative potential of the BIS/BAS constructs for linking psychosocial and biological research on bipolar disorder.