A study of language functioning in Alzheimer patients

Language functioning in Alzheimer's disease is reviewed and the performance of 25 Alzheimer patients on a standard battery is reported. All these hospitalized patients were aphasic to some degree. As a group, they differed from normals on all language variables, and from stroke patients in terms of higher fluency and lower comprehension. Spontaneous speech showed high incidence of circumlocutions and semantic jargon, but no phonemic paraphasias or target approximations. Syllabic perseverations, shouting, inappropriate laughter, and mutism were late-appearing features. Transcortical Sensory, and Wernicke's aphasias were frequent, but Broca's and Transcortical Motor aphasias notably absent. Extent of language impairment correlated with current length of hospitalization but not age. Reading, writing, and performance scores except praxis, were lower than oral language scores. Findings were discussed in relation to previous results, methodology, and language organization in the brain.     

Toward an integrated approach to early childhood stuttering

This article proposes a model that integrates various factors influencing early childhood stuttering. The factors interact in a synergistic manner and can be subsumed under three macrofactors: physiological, psycholinguistic, and psychosocial. Such a model can be clinically applied toward an integrated approach to the assessment and treatment of the young stutterer.     

The problem of relapse in stuttering: Some thoughts on what might cause it and how to deal with it

Bloodstein recently wrote that “the most vital part of science is not accurate measurement or the insistence on empiricism. It is an attitude of inquiry into the how and why of things” [Bloodstein, O. Foreword. In: Maintenance of Fluency (E. Boberg ed.). New York: Elsevier, 1981, p. vii]. In the paper below, I present some unsubstantiated and no doubt controversial thoughts on the how and why of relapse in stuttering. The overall thrust of these thoughts is that stutterers have different propensities to stutter because of the inherent variability in their speech production systems. For this reason, for therapy to have long-range success, stutterers must learn to accept and deal with the inherent variability in their speech production mechanisms.     

Bibliography of literature pertaining to the onset,development, and treatment of stuttering during the preschool years

This bibliography consists of clinical, experimental, and theoretical papers pertaining to the onset, development, and treatment of stuttering in children five- years old and younger. It is a downward extension of Silverman, F.H., Bibliography of literature pertaining to stuttering in elementary-school children, Journal of Fluency Disorders, 1978, 3, 87–102.     

Control of responding by location of auditory stimuli: adjacency of sound and response.

Four rhesus monkeys were trained to respond on one key when a one-second noise burst was presented through one speaker and to respond on a second key when the noise burst was presented through a second speaker. The acquisition of stimulus control was studied under three conditions, in each of which the relationship between the sound source and the response-key positions varied: an adjacent condition in which the noise burst was presented through the key and a response on this key was reinforced; a reversed-adjacent condition in which the noise burst was presented through one key and responding on the other key was reinforced: and a nonadiacent condition in which responding on the key nearer the sound was reinforced. Under adjacent conditions, stimulus control developed within one or two sessions. Under reversed and nonadjacent conditions, 10 sessions were required for the development of control. The asymptote of correct responding was the same under each condition in all animals.     

Fitting cross-classification table data to models when observations are subject to classification error

Individuals are classified in a cross-classification table where two behavioral observations on each individual determine the classification. The problem is to test certain structural models assumed to underlie the cross-classified observations. A minimum chi-square test procedure is proposed.     

Influence of linguistic complexity,rate of presentation,and interphrase pause time on auditory-verbal comprehension of adult aphasic patients

Among the variables affecting comprehension of linguistic stimuli by aphasic subjects are syntactic complexity and processing time. Comprehension performance of 15 aphasic adults was studied while altering the rate of speech presentation and varying the pause time between the major phrases within sentences of increasing grammatical complexity.Simple Active Affirmative Declarative Sentences, Negative, and Passive sentences were presented (1) at the rate of 150 words per minute (wpm) with 1-sec interphrase pause time (IPT); (2) 150 wpm with no pauses; (3) 120 wpm with 1-sec IPT; (4) 120 wpm with no pauses added.Performance was seen to vary with increasing syntactical complexity and as a function of processing time. Greater comprehension was seen with active affirmative than negative; greater with passive affirmative than with active negative. Clinical implications are discussed. Subjects demonstrated greater comprehension when sentences were presented at slower than normal rate; addition of interphrase pause time intervals aided comprehension. Combining slower rate of presentation and IPT intervals provided greatest increase in auditory processing time and showed concomitant increase in comprehension performance.     

Synapses,Schizophrenia, and Civilization: What Made Homo Sapient?

Progress in technology has allowed dynamic research on the development of the human brain that has revolutionized concepts. Particularly, the notions of plasticity, neuronal selection, and the effects of afferent stimuli have entered into thinking about brain development. Here I focus on development from the age of four years to early adulthood, during which a 30 percent reduction in some brain synapses occurs that is out of proportion to changes in neuronal numbers. This corresponds temporally with changes in normal child behavior from the loose‐associative, almost schizoid, thinking and art of the four‐year‐old to the more trained, or disciplined, or acculturated—and restrained—personality of the young adult. I propose that the synaptic changes can best be thought of as a winnowing process likely subject to environmental influences. Acquisition of language and the ability to link linguistic cognition to the plastic development of the brain provide a potentially powerful means of explaining the evolutionally explosive development of human cognition and culture. Schizophrenia, a disease that can be envisioned as representing a derangement of synaptic maturation, may provide an entry into the search for genes controlling the processes mediating the unprecedented development of Homo sapiens over the past 40,000 to 70,000 years. The recently completed mapping of the genome of the chimpanzee provides a new frame of reference that may speed the search.