Functions and Health at the Interface of Biology and Technology

Synthetic biology promises to eliminate the distinction between biology and engineering by delivering a philosophically interesting new kind of entity: a biological organism that is wholly designed and constructed by humans. The possibility of such organisms raises interesting questions in three domains: the analysis of (1) biological functions, (2) engineering functions, and (3) health and disease. This paper identifies and systematically answers these questions. This does not only establish how we should think about functions and health and disease in synthetic biological organisms, but it also reveals insights that are of broader relevance: (1) aetiological accounts of biological function need to omit or reinterpret reference to natural selection. This results in complete continuity between aetiological analyses of function in engineering and philosophy; (2) considering synthetic biology prompts interesting further questions about heritability, ancestry, and biological individuals; and (3) accounts of disease as biological dysfunction do not straightforwardly map onto our intuitive health and disease judgments regarding non-human animals. In response to the latter point I examine three possible avenues, and tentatively defend one on behalf of the ‘disease as dysfunction’ theorist.     

联合Simon效应:现状、影响因素与理论解释

联合Simon效应是一种空间刺激–反应相容性效应,它出现在当两个参与者完成Simon任务的互补成分时。该效应被认为是反映自我–他人整合程度的一个有效指标。影响此现象的因素主要包括社会和非社会因素。社会促进理论、共同表征理论、空间反应编码理论和参照编码理论对该效应作出了解释。未来关于联合Simon效应的研究需深入探讨其影响因素以及脑机制,并进一步完善理论解释。     

Lady Liberty and Godfather Death as candidates for linguistic relativity? Scrutinizing the gender congruency effect on personified allegories with explicit and implicit measures

Linguistic relativity—the idea that language affects thought by way of its grammatical categorizations—has been controversially debated for decades. One of the contested cases is the grammatical gender of nouns, which is claimed to affect how their referents are conceptualized (i.e., as rather female or male in congruence with the grammatical gender of the noun), especially when used allegorically. But is this association strong enough to be detected in implicit measures, and, if so, can we disentangle effects of grammatical gender and allegorical association? Three experiments with native speakers of German tackled these questions. They revealed a gender congruency effect on allegorically used nouns, but this effect was stronger with an explicit measure (assignment of biological sex) than with an implicit measure (Extrinsic Affective Simon Task) and disappeared in the implicit measure when grammatical gender and allegorical associations were set into contrast. Taken together, these findings indicate that the observed congruency effect was driven by the association of nouns with personifications rather than by their grammatical gender. In conclusion, we also discuss implications of these findings for linguistic relativity.     

A Stronger Doctrine of Double Effect

Many believe that intended harms are more difficult to justify than are harms that result as a foreseen side effect of one's conduct. We describe cases of harming in which the harm is not intended, yet the harmful act nevertheless runs afoul of the intuitive moral constraint that governs intended harms. We note that these cases provide new and improved counterexamples to the so-called Simple View, according to which intentionally phi-ing requires intending to phi. We then give a new theory of the moral relevance of intention. This theory yields the traditional constraint on intending harm as a special case, along with several stronger demands.     

Decreased functional brain activation in Friedreich ataxia using the Simon effect task

The present study applied the Simon effect task to examine the pattern of functional brain reorganization in individuals with Friedreich ataxia (FRDA), using functional magnetic resonance imaging (fMRI). Thirteen individuals with FRDA and 14 age and sex matched controls participated, and were required to respond to either congruent or incongruent arrow stimuli, presented either to the left or right of a screen, via laterally-located button press responses. Although the Simon effect (incongruent minus congruent stimuli) showed common regions of activation in both groups, including the superior and middle prefrontal cortices, insulae, superior and inferior parietal lobules (LPs, LPi), occipital cortex and cerebellum, there was reduced functional activation across a range of brain regions (cortical, subcortical and cerebellar) in individuals with FRDA. The greater Simon effect behaviourally in individuals with FRDA, compared with controls, together with concomitant reductions in functional brain activation and reduced functional connectivity between cortical and sub-cortical regions, implies a likely disruption of cortico-cerebellar loops and ineffective engagement of cognitive/attention regions required for response suppression.     

Rushton’s contributions to the study of mental ability

This essay describes Rushton’s contribution to examining the nexus of intelligence, race, and genetics, specifically what I termed “Spearman’s hypothesis”. It states that Black–White differences are “most marked in just those [tests] which are known to be saturated with g”. I (Jensen) had confirmed this hypothesis using large data sets in the 1970s and 1980s and also found that Black–White differences were most marked on the more heritable rather than the more cultural subtests. Rushton confirmed and extended these findings in many highly innovative ways and demonstrated Spearman’s hypothesis applied among samples of Gypsy Roma in Serbia, and East Asian, European, South Asian, Colored and Black samples in South Africa. He has not only documented group differences in brain size, intelligence, life span, family structure, infant mortality, developmental precocity, personality, and temperament, and rates of two egg twinning, and crime among East Asians, Europeans, and Africans, but also provided a life history theory that explains them.     

Temporal dynamics of interference in Simon and Eriksen tasks considered within the context of a dual-process model

Behavioral and brain potential measures were employed to compare interference in Eriksen and Simon tasks. Assuming a dual-process model of interference elicited in speeded response tasks, we hypothesized that only lateralized stimuli in the Simon task induce fast S–R priming via direct unconditional processes, while Eriksen interference effects are induced later via indirect conditional processes. Delays to responses for incongruent trials were indeed larger in the Eriksen than in the Simon task. Only lateralized stimuli in the Simon task elicited early S–R priming, maximal at parietal areas. Incongruent flankers in the Eriksen task elicited interference later, visible as a lateralized N2. Eriksen interference also elicited an additional component (N350), which accounted for the larger behavioral interference effects in the Eriksen task. The findings suggest that interference and its resolution involve different processes for Simon and Eriksen tasks.     

Thomas Aquinas and Antonio de Córdoba on self-defence: saving yourself as a private end

ABSTRACT

Revisionists about Aquinas’ teaching on private self-defence take the standard reading to hold that Aquinas applies a version of the Doctrine of Double Effect (DDE) according to which the intentional killing of a wrongful attacker by a private person is morally prohibited while the non-intentional but foreseeable killing of the attacker is permitted. Revisionists dispute this reading and argue that Aquinas permits the intentional killing of wrongful attackers. I argue that revisionists mischaracterize the standard reading of Aquinas. I consider one of its main proponents, Antonio de Córdoba (1485–1579). When Córdoba condemned the intentional killing of wrongful attackers by private persons, he was not applying DDE. Rather, he was arguing that when you decide to kill an attacker you treat the attacker as a resource for the private end of saving your life. Killing a member of your community is a form of irrevocable social exclusion. This decision ought to be left to the public authorities. The disagreement between the authors defending the standard view and their critics was not about DDE but rather about the moral limits that membership in a community sets on the pursuit of private ends, including the private end of staying alive.     

Measuring Fear of Movement/(Re)injury in Chronic Low Back Pain Using Implicit Measures

Fear of movement/(re)injury is assumed to contribute to the development and maintenance of chronic low back pain (CLBP) in a subgroup of patients. Studying fear of movement/(re)injury with implicit attitude measures, without the awareness of the patient, might be a valuable addition to self‐report questionnaires. The aims of the current study were to investigate whether CLBP patients demonstrate more implicit fear of movement/(re)injury than healthy controls, and whether 2 implicit measures are related to each other, and to an explicit self‐report measure of fear of movement/(re)injury. A group of 66 CLBP patients and 30 healthy controls took part in this study. In addition to self‐report questionnaires, fear of movement/(re)injury was implicitly assessed by the Extrinsic Affective Simon Task (EAST) and the Go‐No‐Go‐Association Task (GNAT) that aimed to determine the association between back‐stressing movements and the evaluation “threatening”. On both implicit tasks it was found that neither CLBP patients nor healthy controls demonstrated implicit fear of movement/(re)injury, and that CLBP patients did not differ from healthy controls in their level of implicit fear of movement/(re)injury. In general, no associations were found between the EAST and the GNAT, or between implicitly measured and self‐reported fear of movement/(re)injury. One major caveat in drawing inferences from these findings is the poor reliability of these implicit measures. Research towards the psychometric properties of these measures should first be expanded before modifying, and applying, them to more complex domains such as fear of movement/(re)injury.