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兴奋性氨基酸(EAAs) 广泛分布于中枢神经系统,参与多种生理过程包括学习、记忆和伤害感受等。然而,EAAs 受体的过度兴奋却可引发一系列细胞事件,最终导致神经元的损伤与死亡。许多神经退行性疾病如早老性痴呆、癫痫和肌侧索硬化症等都与EAAs 的兴奋毒作用有关。目前的研究表明,由EAAs 受体过度兴奋所引发的细胞内钙超载是导致神经元死亡的最终途径 相似文献
164.
Jake Epker Ann Matt Maddrey Randall Rosenblatt 《Journal of clinical psychology in medical settings》1999,6(4):393-403
The Multidimensional Pain Inventory (MPI) was utilized in a sample of adult outpatients with cystic fibrosis (CF) to assess their perception of pain and its psychosocial consequences. Subsequently, the data were compared to the ratings of pain and pain-related impairment in these patients as perceived by two nurses from the CF treatment team, as well as to a quantitative measure of illness severity. The results of these comparisons demonstrate that the majority of adult outpatients with CF reported experiencing lower levels of pain and pain-related impairment than expected, although the male patients tend to report experiencing significantly less impact in these domains than do the female patients. Additionally, the nurses do not underestimate the degree to which patients, especially males, experience pain and pain-related interference from chronic illness. Finally, there was no significant relationship between patients' self-report of pain severity or pain-related interference and an objective measure of disease severity. 相似文献
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Susan Wolf 《The Journal of Ethics》1999,3(3):203-223
According to one influential conception of morality, being moral is a matter of acting from or in accordance with a moral point of view, a point of view which is arrived at by abstracting from a more natural, pre-ethical, personal point of view, and recognizing that each person's personal point of view has equal standing. The idea that, were it not for morality, rational persons would act from their respectively personal points of view is, however, simplistic and misleading. Because our nonmoral reasons cannot all be adequately captured as falling within any single, unified and coherent point of view, morality cannot be adequately understood as a matter of abstracting from such points of view and taking them all equally into account. After considering several ways of modifying the initial conception of morality in a way that accommodates the variety of nonmoral reasons that do not have their source in a personal point of view, the paper concludes with the suggestion that we free ourselves more thoroughly from the grip of the metaphor that takes morality as a whole to be a matter of acting in accordance with the judgments of a single unified and coherent point of view. 相似文献
167.
自控摄入小剂量酒精影响熟练驾驶行为的实验研究 总被引:1,自引:1,他引:0
一个小样本受试者内设计实验,受试者在实验允许的酒精剂量范围内自由选择摄入量。实验安排饮酒前,酒后30分钟、110分钟和170分钟四个测试阶段,分别检验受试者在模拟驾驶和实际驾驶两项任务中的认知行为。酒后30分钟实际驾驶的技能与其他三个测试期相比存在有意义的差别显著性;模拟测试任务中酒后对红、黄两种信号灯的认知反应时之间呈现显著性差别,酒后110分钟对黄色信号灯的反应明显延迟。研究提示:受试对酒精感受性的估计是不可靠的,小剂量酒精也能对驾驶行为构成伤害。 相似文献
168.
Evaluating the Factor Structure of the MIDI Personality Scale Using Exploratory Structural Equation Modeling 下载免费PDF全文
Mohsen Joshanloo 《The Japanese psychological research》2018,60(3):162-169
This study investigated the factor structure of the 26‐item Midlife Development Inventory (MIDI) Personality Scale in a sample of 2,720 Americans. It was found that whereas confirmatory factor analysis (CFA) did not provide an acceptable fit to the data, exploratory structural equation modeling (ESEM) provided an acceptable fit. The results of ESEM revealed that the a priori five‐factor structure of personality was generally consistent with the data, and all items had salient loadings on their target factors. ESEM also revealed that some of the items contributed significantly to more than one personality factor. The results are in line with previous research, and indicate that ESEM is more suitable than CFA for the study of personality traits. 相似文献
169.
Leg-to-body ratio (LBR) is one of the morphological traits that influences a person's attractiveness. To date, studies confirming that hypothesis have been conducted mainly in Western cultures. They have shown that the average or slightly higher-than-the-average LBR is perceived to be attractive in women. In the case of men, results were more ambiguous; however generally shorter or similar LBRs compared to females were attractive. Here, data on LBR preferences of a traditional, semi-nomad ethnic group (i.e., the Himba of northern Namibia, n = 81) are reported. Also in Himba people LBR influences a person's attractiveness. Similar to Western societies, extremely high and low LBRs were unattractive. However, contrary to previous findings, Himba preferred women of relatively low LBR and men of relatively high LBR. 相似文献
170.
《The Journal of social psychology》2012,152(6):767-783
ABSTRACT Work values influence our attitudes and behavior at work, but they have rarely been explored in the context of work stress. The aim of this research was thus to test direct and moderating effects of Chinese work values (CWV) on relationships between work stressors and work well-being among employees in the Greater China region. A self- administered survey was conducted to collect data from three major cities in the region, namely Beijing, Hong Kong, and Taipei (N = 380). Work stressors were negatively related to work well-being, whereas CWV were positively related to work well-being. In addition, CWV also demonstrated moderating effects in some of the stressor–job satisfaction relationships. 相似文献