Altered attention for stimuli on the hands

Attention operates in the space near the hands with unique, action-related priorities. Here, we examined how attention treats objects on the hands themselves. We tested two hypotheses. First, attention may treat stimuli on the hands like stimuli near the hands, as though the surface of the hands were the proximal case of near-hand space. Alternatively, we proposed that the surface of the hands may be attentionally distinct from the surrounding space. Specifically, we predicted that attention should be slow to orient toward the hands in order to remain entrained to near-hand space, where the targets of actions are usually located. In four experiments, we observed delayed orienting of attention on the hands compared to orienting attention near or far from the hands. Similar delayed orienting was also found for tools connected to the body compared to tools disconnected from the body. These results support our second hypothesis: attention operates differently on the functional surfaces of the hand. We suggest this effect serves a functional role in the execution of manual actions.     

The sandwich model: The ‘music and dance’ of therapeutic action

My premise is that a ‘layered’ approach is necessary to understand the process of exchanges that result in therapeutic change. I imagine these processes occurring in three layers – although the number of domains in which change is taking place is actually infinite – such as in a sandwich. The top layer, or top slice of bread of the sandwich, represents a broad view of the change process; it is non‐linear and includes the feature of uncertainty, a general principle of dynamic systems theory. The middle layer, or the meat of the sandwich, is explained by theories that are immediately and clinically useful to a therapist, such as psychoanalytic theories. These are primarily linear theories and use language and symbols to ‘tell a story of what happened’. The bottom layer, or bottom slice of bread of the sandwich, is the micro‐process; this layer includes the moment‐to‐moment patterns of coordinated rhythms that both communicate meaning and provide the essential scaffold for all higher‐level change processes. The micro‐process also requires a non‐linear theory to make sense of its variability and emergent properties. Taking a bite out of the sandwich will include a ‘polysemic bundle of communicative behaviors’ (Harrison and Tronick, 2011). I will illustrate the ‘sandwich model’ with the clinical case of the analytic treatment of a 5 year‐old boy.     

Belief-based action prediction in preverbal infants

Successful mindreading entails both the ability to think about what others know or believe, and to use this knowledge to generate predictions about how mental states will influence behavior. While previous studies have demonstrated that young infants are sensitive to others’ mental states, there continues to be much debate concerning how to characterize early theory of mind abilities. In the current study, we asked whether 6-month-old infants appreciate the causal role that beliefs play in action. Specifically, we tested whether infants generate action predictions that are appropriate given an agent’s current belief. We exploited a novel, neural indication of action prediction: motor cortex activation as measured by sensorimotor alpha suppression, to ask whether infants would generate differential predictions depending on an agent’s belief. After first verifying our paradigm and measure with a group of adult participants, we found that when an agent had a false belief that a ball was in the box, motor activity indicated that infants predicted she would reach for the box, but when the agent had a false belief that a ball was not in the box, infants did not predict that she would act. In both cases, infants based their predictions on what the agent, rather than the infant, believed to be the case, suggesting that by 6 months of age, infants can exploit their sensitivity to other minds for action prediction.     

Effects of aging on whole body and segmental control while obstacle crossing under impaired sensory conditions

The ability to safely negotiate obstacles is an important component of independent mobility, requiring adaptive locomotor responses to maintain dynamic balance. This study examined the effects of aging and visual–vestibular interactions on whole-body and segmental control during obstacle crossing. Twelve young and 15 older adults walked along a straight pathway and stepped over one obstacle placed in their path. The task was completed under 4 conditions which included intact or blurred vision, and intact or perturbed vestibular information using galvanic vestibular stimulation (GVS). Global task performance significantly increased under suboptimal vision conditions. Vision also significantly influenced medial–lateral center of mass displacement, irrespective of age and GVS. Older adults demonstrated significantly greater trunk pitch and head roll angles under suboptimal vision conditions. Similar to whole-body control, no GVS effect was found for any measures of segmental control. The results indicate a significant reliance on visual but not vestibular information for locomotor control during obstacle crossing. The lack of differences in GVS effects suggests that vestibular information is not up-regulated for obstacle avoidance. This is not differentially affected by aging. In older adults, insufficient visual input appears to affect ability to minimize anterior–posterior trunk movement despite a slower obstacle crossing time and walking speed. Combined with larger medial–lateral deviation of the body COM with insufficient visual information, the older adults may be at a greater risk for imbalance or inability to recover from a possible trip when stepping over an obstacle.     

Postural leaning direction challenges the manifestation of tendon vibration responses at the ankle joint

In this study, we examined the interaction between central and peripheral proprioceptive afferent pathways by applying ankle tendon vibration during postural leaning in different directions. Twenty young participants stood for 60s over the midline of two adjacent force platforms in (a) neutral stance distributing Body Weight (BW) equally between the platforms, (b) forward leaning transferring 80% of BW to the front platform and (c) backward leaning transferring 80% of BW to the rear platform. Participants controlled the degree of leaning by receiving on-line visual feedback of BW distribution matched to a target line. Vibration (80 Hz, 1.5–1.8 mm) was applied over the Achilles or tibialis anterior tendon during the middle 20s of standing. This induced a postural shift towards the vibration side and an increase in the variability of the BW distribution that was greater in backward compared to forward leaning. EMG responses to tendon vibration were independent of the leaning direction. Antagonistic activity also increased in response to vibration, the amplitude of this increase however was direction dependent. These results favor the hypothesis about the central co-modulation of the vibration evoked proprioceptive inflow based on postural and visual feedback rather than muscle tension constraints.     

Behavioral science integration: A practical framework of multi-level converging evidence for behavioral science theories

Several frameworks exist to help science in organizing known information, connecting previously disparate phenomena, promoting understanding, and identifying gaps in knowledge. This paper integrates previous frameworks that have been used in the behavioral sciences to produce a more comprehensive, specific, and complete framework, consonant with the process of scientific discovery as based on multiple, independent, and converging lines of evidence. This multi-level convergence framework is designed specifically for the analysis and understanding of human cognitive/behavioral traits, in contrast to more general frameworks that are designed to be applied relatively widely (such as across all information processing systems or across all biological organisms). This integrated framework overcomes gaps in prior frameworks, provides a more complete picture of the interrelationships between various aspects of the behavioral sciences, and can aid in evaluating theories, both for comparison and identifying gaps in evidentiary support.     

临床医学整合：中心化整合关键在于观念转变

医学转型的实质是推进医学的整合,微观层面以临床医学的整合为核心部分,宏观上则以临床医学与预防医学的整合为核心。在诸多整合之中,以临床医学的整合最为迫切,它是整个医学整合过程中的基础和开端。当前进行的临床中心化整合似乎已成为一种主导的趋势,然而,如何进行中心化整合却仍然存在诸多问题需要探讨,某些医院对专科化的热衷和偏爱更令人担忧,医学资本的诱惑也是当今临床整合的一道障碍,因此,医学整合任重而道远,不仅需要医学形式上的重组,更需要有观念上的根本转变。     

Modelling audiovisual integration of affect from videos and music

Two experiments examined how affective values from visual and auditory modalities are integrated. Experiment 1 paired music and videos drawn from three levels of valence while holding arousal constant. Experiment 2 included a parallel combination of three levels of arousal while holding valence constant. In each experiment, participants rated their affective states after unimodal and multimodal presentations. Experiment 1 revealed a congruency effect in which stimulus combinations of the same extreme valence resulted in more extreme state ratings than component stimuli presented in isolation. An interaction between music and video valence reflected the greater influence of negative affect. Video valence was found to have a significantly greater effect on combined ratings than music valence. The pattern of data was explained by a five parameter differential weight averaging model that attributed greater weight to the visual modality and increased weight with decreasing values of valence. Experiment 2 revealed a congruency effect only for high arousal combinations and no interaction effects. This pattern was explained by a three parameter constant weight averaging model with greater weight for the auditory modality and a very low arousal value for the initial state. These results demonstrate key differences in audiovisual integration between valence and arousal.     

Discounting model selection with area‐based measures: A case for numerical integration

A novel method for analyzing delay discounting data is proposed. This newer metric, a model‐based Area Under Curve (AUC) combining approximate Bayesian model selection and numerical integration, was compared to the point‐based AUC methods developed by Myerson, Green, and Warusawitharana (2001) and extended by Borges, Kuang, Milhorn, and Yi (2016). Using data from computer simulation and a published study, comparisons of these methods indicated that a model‐based form of AUC offered a more consistent and statistically robust measurement of area than provided by using point‐based methods alone. Beyond providing a form of AUC directly from a discounting model, numerical integration methods permitted a general calculation in cases when the Effective Delay 50 (ED50) measure could not be calculated. This allowed discounting model selection to proceed in conditions where data are traditionally more challenging to model and measure, a situation where point‐based AUC methods are often enlisted. Results from simulation and existing data indicated that numerical integration methods extended both the area‐based interpretation of delay discounting as well as the discounting model selection approach. Limitations of point‐based AUC as a first‐line analysis of discounting and additional extensions of discounting model selection were also discussed.     

Balancing awareness: Vestibular signals modulate visual consciousness in the absence of awareness

The processing of visual and vestibular information is crucial for perceiving self-motion. Visual cues, such as optic flow, have been shown to induce and alter vestibular percepts, yet the role of vestibular information in shaping visual awareness remains unclear. Here we investigated if vestibular signals influence the access to awareness of invisible visual signals. Using natural vestibular stimulation (passive yaw rotations) on a vestibular self-motion platform, and optic flow masked through continuous flash suppression (CFS) we tested if congruent visual–vestibular information would break interocular suppression more rapidly than incongruent information. We found that when the unseen optic flow was congruent with the vestibular signals perceptual suppression as quantified with the CFS paradigm was broken more rapidly than when it was incongruent. We argue that vestibular signals impact the formation of visual awareness through enhanced access to awareness for congruent multisensory stimulation.