Inactivation of the basolateral amygdala impairs the retrieval of recent and remote taste-potentiated odor aversion memory

Memory reorganization as a time-dependent process can be investigated using various learning tasks such as the taste-potentiated odor aversion (TPOA). In this paradigm rats acquire a strong aversion to an olfactory cue presented simultaneously with a gustatory cue. Together these cues are paired with a delayed visceral illness. The basolateral amygdaloid nucleus (BLA) plays a key role in TPOA acquisition but its involvement in retrieval remains unclear. We investigated the involvement of the BLA in either recent or remote retrieval of TPOA. In each case, the number of licks observed in response to the presentation of either the odor or the taste was used to assess retrieval. Before the retrieval test, rats received a bilateral infusion of lidocaine to inactivate the BLA. We observed that both recent and remote TPOA retrieval tests induced by the odor presentation were disrupted in the lidocaine-injected rats. By contrast, the BLA inactivation had no effect upon the aversion towards the taste cue regardless of the time of retrieval. The present study provides evidence that BLA functioning is necessary for retrieval of aversive odor memory, even with a long post-acquisition delay.     

Satisficing in financial decision making — a theoretical and experimental approach to bounded rationality

We apply the theoretical construct of bounded rationality to an investment game, allowing participants to invest their monetary endowment in riskless bonds and risky assets. In our experiment, we elicit aspiration levels from participants: one captures a subsistence threshold, the other a success threshold. Participants can be classified according to these aspirations and the corresponding investment behavior. We differentiate between potential and actual satisficing. By presupposing specific cardinal utility functions, we also relate the bounded rationality approach to the traditional rational choice model.     

Associations Between Breast Cancer Risk Factors and Religiousness in American Women in a National Health Survey

Breast cancer is a leading cause of death in American women. Data are lacking from representative samples of total populations on the association of risk factors for breast cancer and religiousness. The sixth cycle of the National Survey of Family Growth (NSFG VI) included 3,766 women aged 30–44 years with complete data on self-reported religiousness, and selected breast cancer risk factors. Of women in the analysis, 1,008 reported having four or more breast cancer risk factors. Women who never attended services were over seven times more likely to report having four or more risk factors than those who attended more than weekly (P < 0.0001). After adjusting for age, race, Hispanic ethnicity, nativity, education and marital status by logistic regression, women who never attended services were still over six times more likely to report having four or more risk factors (P < 0.0001). The combination of frequent attendance at religious services, very high importance of religion in daily life, and self-identification as a Protestant evangelical was particularly protective. Multiple dimensions of religiousness are independently associated with multiple breast cancer risk factors.     

Individuals high in neuroticism are not more reactive to adverse events

Numerous studies have related neuroticism to negative emotional outcomes of adverse life events, including post-traumatic stress disorder (PTSD) symptoms. However, the nature of the relationship between neuroticism and post-trauma symptoms is unclear. The purpose of this study was to prospectively examine whether individuals high in neuroticism, relative to low neuroticism individuals, show a larger increase in symptoms after an adverse event. A sample of infantry troops completed questionnaires before deployment to Iraq (n = 214) and about five months (n = 170; 76%) thereafter. The findings showed that, after controlling for an indicator of trauma severity, (a) higher neuroticism individuals reported more PTSD symptoms, depression symptoms, and somatic problems after negative events, and (b) these relationships disappeared after controlling for pre-trauma symptoms. There were no significant differences between individuals high and low in neuroticism in the increase in symptoms from pre to post-trauma. This suggests that individuals high in neuroticism are not more reactive to adverse events.     

Myopic regret avoidance: Feedback avoidance and learning in repeated decision making

Decision makers can become trapped by myopic regret avoidance in which rejecting feedback to avoid short-term outcome regret (regret associated with counterfactual outcome comparisons) leads to reduced learning and greater long-term regret over continuing poor decisions. In a series of laboratory experiments involving repeated choices among uncertain monetary prospects, participants primed with outcome regret tended to decline feedback, learned the task slowly or not at all, and performed poorly. This pattern was reversed when decision makers were primed with self-blame regret (regret over an unjustified decision). Further, in a final experiment in which task learning was unnecessary, feedback was more often rejected in the self-blame regret condition than in the outcome regret condition. We discuss the findings in terms of a distinction between two regret components, one associated with outcome evaluation, the other with the justifiability of the decision process used in making the choice.     

Similar Processes Despite Divergent Behavior in Two Commonly Used Measures of Risky Decision Making

Performance on complex decision-making tasks may depend on a multitude of processes. Two such tasks, the Iowa Gambling Task (IGT) and Balloon Analog Risk Task (BART), are of particular interest because they are associated with real world risky behavior, including illegal drug use. We used cognitive models to disentangle underlying processes in both tasks. Whereas behavioral measures from the IGT and BART were uncorrelated, cognitive models revealed two reliable cross-task associations. Results suggest that the tasks similarly measure loss aversion and decision-consistency processes, but not necessarily the same learning process. Additionally, substance-using individuals (and especially stimulant users) performed worse on the IGT than healthy controls did, and this pattern could be explained by reduced decision consistency.     

Cognitive components in risk perception: Natural versus manmade risks

In a questionnaire study 106 Norwegian students rated natural and manmade hazards according to risk magnitude and public versus private responsibility for risk management. Another group of 50 subjects judged 36 natural hazards on nine risk dimensions used in previous psychometric studies of ‘manmade risks’. When ratings on nine risk characteristics for natural hazards were factor analyzed a three-dimensional solution was found, with one active/passive dimension, one potency dimension, and one novelty dimension. This contrasts with the two-dimensional solution found for manmade hazards. Responsibility for risk management was found to be related to the type of risk in focus, and different risk characteristics seem to play different roles for manmade and natural hazards.     

Perceived control,nature of risk information and risk taking. An experimental test of a simple taxonomy of uncertainty

Uncertainty may be categorized along two dimensions: (1) the nature of probabilistic information (i.e. frequency information, about the outcomes of similar situations in the past, versus process information, about the way(s) in which a future loss might occur), and (2) the degree of personal control (i.e. the extent to which an activity's outcomes depend on internal factors (e.g. knowledge, skills) versus external (e.g. chance) factors). The effects of variations in both dimensions on people's risk-taking tendency were experimentally studied. In a computerized task, subjects had to stop a fast-moving symbol before it passed a target line. Success yielded a financial gain, failure led them into a ‘penalty task’ with the possibility of a considerable loss. On each trial subjects chose among 10 risk levels (varying symbol speeds): low levels resulted in small but almost sure gains, high levels yielded larger but less probable gains. Across subgroups of subjects, three penalty task characteristics were varied: (1) the actual loss probability, (2) the external versus internal determination of outcomes, and (3) the available risk information. Major findings were: (a) subjects did not set a lower risk level, but they did appear to be more attentive (i.e. they failed fewer trials) when the actual loss probability was lower; (b) internal outcome determination resulted in more failed trials (lesser caution); (c) subjects ignored frequency information, but were sensitive to process information. Results are discussed in terms of effort allocation for controlling risk during task performance.     

Evaluating anxiety sensitivity and other fundamental sensitivities predicting anxiety symptoms and fearful responding to a biological challenge

Fear of arousal symptoms, often referred to as anxiety sensitivity (AS), appears to be associated with risk for anxiety pathology and other Axis I conditions. However, AS is only one of three fundamental components of Reiss' Expectancy Model proposed to account for the development of anxiety problems. Very little research has focused on the other two components of this model (Fear of Negative Evaluation, Illness/Injury Sensitivity) and the specificity of AS, relative to these other two components, has rarely been evaluated. This study evaluated general and unique associations among all three so-called fundamental sensitivities to fearful responding to a biological challenge in a nonclinical sample (N=404). Participants were administered a 20-s inhalation of 20% CO2/balance O2. Consistent with hypothesis, only AS uniquely contributed to increased subjective fear responding to the challenge. These findings are consistent with Expectancy Theory in suggesting that the AS component of the model is specific to amplification of fears to arousal cues.