Initial responses to the first dose of nicotine in novel smokers: The role of exposure to environmental smoking and genetic predisposition

Background: Sensitivity to initial smoking constitutes an early predictor of the risk of dependence. We investigated the role of exposure to smoking (by parents, siblings, and peers) and reward-related candidate gene polymorphisms (OPRM1 A118G, DRD2 TaqlA and DRD4?bp VNTR) in adolescents’ responses to initial smoking.

Methods: We used cross-sectional survey data and saliva samples from 171 Dutch students who had never inhaled on a cigarette (mean age: 13.9?years). The outcome measure was adolescents’ self-reported responses to initial smoking.

Results: Exposure to peer smoking was associated with increased liking (OR?=?1.74, CI?=?1.13–2.70) and more pleasant sensations (β?=?.21, p?=?.01). Exposure to maternal smoking was associated with less unpleasant sensations (β?=??.20, p?=?.01). Adolescents carrying the G-variant of the OPRM1 A118G polymorphism were more likely to report liking (OR?=?2.50, CI?=?1.09–5.73) and adolescents homozygous for the C-variant of the DRD2 TaqlA polymorphism reported less unpleasant sensations (β?=?.18, p?=?.04).

Conclusion: Although preliminary, these findings suggest that exposure to environmental smoking and polymorphisms in the OPRM1 and DRD2 gene may affect initial sensitivity to nicotine, an early phenotype of the risk of dependence. In the future, collaborative efforts to combine data from multiple studies in meta-analyses are needed to improve accuracy of estimated effects in genetic studies.     

Disgust sensitivity and the HEXACO model of personality

In the current investigation, we test for relationships between three domains of disgust sensitivity (pathogen, sexual, and moral disgust) and the six dimensions of the HEXACO personality model in a large, demographically diverse Dutch sample. Our results extend upon previous investigations into the relationship between disgust sensitivity and personality in two important ways. First, in contrast with most previous investigations into disgust sensitivity, we measure sensitivities to sexual and moral disgust, two domains that elicit self-reports of disgust and facial expressions of disgust. Second, in contrast with the few investigations that have tested for relationships between sensitivities to sexual and moral disgust and Five Factor Model personality dimensions, we use the HEXACO personality model. We find that honesty–humility, a personality dimension assessed in the HEXACO model but not the Five Factor Model, accounts for unique variance in sensitivities to sexual and moral disgust, but not sensitivity to pathogen disgust. Other relationships between disgust sensitivity and personality are discussed, as are implications for understanding the fitness-relevant tradeoffs potentially underlying disgust sensitivity and personality.     

Reinforcement sensitivity theory as a predictor of senior-executive performance

This paper develops and tests links between the reinforcement sensitivity theory of personality and senior-executive job performance, hypothesising that the theory’s personality traits, known as ‘BIS’ and ‘BAS’, will interact to predict performance. 167 chief and second-tier executives completed Carver and White’s (1994)BIS/BAS Scales, and had their overall performance rated by a superior or peer using four items. Structural equation modeling showed that while BAS has no main effect and BIS has a marginally significant effect on performance (p = 0.07), BIS and BAS interact to predict performance (p = 0.01), the optimal scenario being a combination of high BAS and low BIS. These results show the importance of testing traits’ interactions in applied personality research.     

Perceptual negativity predicts greater reactivity to negative events in daily life

Reinforcement sensitivity theory includes the idea that people differ in their sensitivity to negative events, but relevant process-based assessments have not been developed. The present studies assessed sensitivity to negative events in terms of the extent to which negative word stimuli were perceived to be larger than neutral word stimuli. There was a general tendency to overestimate the size of negative relative to neutral words, but individuals differed substantially in this form of what is termed perceptual negativity. Of more importance, two studies (total N = 151) found systematic relationships between individual differences in perceptual negativity and reactivity to negative events in daily diary protocols. Study 1 found that within-person variations in the occurrence of daily negative events undermined goal-related optimism to a greater extent at higher, relative to lower, levels of perceptual negativity. Study 2 conceptually replicated this interaction in the context of within-person associations between the occurrence of daily negative events and antisocial behavior. These findings are important in advancing reinforcement sensitivity theory, in operationalizing a particular component of it, and in extending it to reactivity processes in daily life.     

Association between maternal sensitivity and externalizing behavior from preschool to preadolescence

Using data from the longitudinal NICHD Study of Early Child Care and Youth Development (N = 1364), this study examined the association between mothers' sensitivity and children's externalizing behavior from preschool to preadolescence. Externalizing behavior declined on average across this period with a slowing of this decline around middle childhood. Maternal sensitivity remained relatively stable on average, and there was significant variation across mothers. A decrease in maternal sensitivity from ages 3 to 11 was related to an increase in externalizing behavior from ages 4 to 12. A model-based test of the direction of the effect suggested that the association between changes in maternal sensitivity and externalizing behavior from ages 4 to 11 was driven by child effects on mothers and not vice-versa. Between late preschool age and preadolescence, the behavior problems of children appear to strongly influence the sensitive support of mothers. Practical implications were discussed in light of these findings.     

Task relevance modulates processing of distracting emotional stimuli

Relatively little is known about the integration of people's fear-related dispositions and their expectations about stressful events. This research used information integration theory to examine how participants’ anxiety sensitivity and event expectancy are integrated to determine their social anxiety. Three studies were conducted—two with university students and one with anxiety clinic patients—in which participants were presented with multiple scenarios of a socially embarrassing event, each representing a different degree of event probability, from which subjective expectancies were derived. Independent variables included anxiety sensitivity (low, moderate, high) and event expectancy (low, medium, high, no probability information). Participants were asked to indicate their anxiety (dependent measure) in each expectancy condition in this 3 × 4 mixed, quasi-experimental design. The results of all three studies strongly suggest that anxiety sensitivity and event expectancy are integrated additively to produce social anxiety. Additional results and their implications for the treatment of anxiety-related disorders are also discussed.     

The moderating role of distress tolerance in the association between anxiety sensitivity physical concerns and panic and PTSD-related re-experiencing symptoms

Abstract

The present investigation evaluated the moderating role of distress tolerance (DT) in the relation between the physical concerns (PC) dimension of anxiety sensitivity (AS–PC) and panic and posttraumatic stress disorder (PTSD)-related re-experiencing symptoms in a nonclinical, undergraduate sample (n = 416; 300 females; M _age=20.3 years, SD = 4.8). Consistent with prediction, there was a significant interactive effect between AS–PC and DT in regard to panic symptoms, such that greater AS–PC and low DT was associated with greater panic symptoms after controlling for the variance accounted for by negative affectivity and the respective main effects. However, contrary to prediction, AS–PC and DT did not significantly interact to predict PTSD-related re-experiencing symptoms. Also consistent with prediction, there was no interactive effect apparent for symptoms of depression or general anxiety, suggesting that the interaction between AS–PC and DT is specific to panic psychopathology.     

Where a person with a squint is actually looking: Gaze-cued orienting in crossed eyes

In this study, we investigated gaze-cued attention orienting when the perceived eyes are not looking in the same direction. This condition occurs in strabismus (squint). Participants were asked to detect laterally presented reaction signals preceded by schematic faces in which the direction (left, straight, or right) of the left and right eye was independently manipulated. Consistent with earlier studies, the results showed a reliable cuing effect by two eyes with parallel gaze direction. Gaze-cued orienting was also shown in a situation when one eye was averted and the other eye was looking straight ahead. The gaze cuing was not significantly stronger in the former than in the latter situation. When both eyes were either nasally or temporally averted, no shifts of visual attention were observed. The results suggest that, if both eyes are visible, the direction of both eyes is computed and integrated for the gaze-cued orienting.     

Stress and stress management at the workplace

Anxiety sensitivity (AS), the fear of anxiety-related symptoms, is strongly implicated in the development of anxiety disorders and is associated with other types of psychopathology. Little is known, though, about the processes through which AS might precipitate distress. As a preliminary step in understanding mechanisms, the mediational role of stress perception was evaluated in a nonclinical sample using a cross sectional design. We conducted a comparison between trait anxiety (TA) and AS to test whether any observed relations were specific to fear of anxiety (AS) or whether associations could be explained by the more general construct. Perceived stress mediated the relation between AS, and specific AS components, and panic symptoms and depression; but not in analyses where TA was statistically controlled. Perceived stress was not found to mediate the relation between TA and panic symptoms or depression, although TA, perceived stress and depression were highly correlated. Although incremental validity was not demonstrated in the present study, stress perception may be an important process through which AS amplifies reactivity to demanding life circumstances and further study is warranted.     

Philosophical Sensitivity

Although much has been written about the nature of philosophy and how the discipline can be defined, little attention has been paid to the ways we develop the facility to reflect philosophically or why cultivating this ability is valuable. This article develops a conception of “philosophical sensitivity,” a perceptual capacity that facilitates our awareness of the philosophical dimension of experience. Based in part on Aristotle's notion of a moral perceptual capacity, philosophical sensitivity starts with most people's natural inclinations as children to reflect about life's fundamental mysteries; when this capacity is cultivated with training over time, our attentiveness to the philosophical features of ordinary life becomes almost second nature. In much the same way an aesthetically sensitive person notices certain qualities of experience not readily perceptible by others, philosophical sensitivity involves the development of a particular way of seeing the world.