Abnormal and normal obsessions: a reconsideration

Contemporary cognitive approaches to obsession assume that the content of clinical obsessions does not differ from non-clinical obsessive intrusions. This assumption goes back to a classic study by Rachman and De Silva [(1978). Abnormal and normal obsessions. Behaviour Research and Therapy, 16, 233-248]. In the present paper, it is argued that Rachman and De Silva did not postulate a complete indifference between clinical and non-clinical obsessions. Study 1 is a simple statistical analysis of data presented by Rachman and De Silva. This analysis suggested that psychologists are able to discriminate clinical and non-clinical obsessions beyond chance level, merely by looking at the content of obsessions. In study 2, a list of 23 clinical and 47 non-clinical obsessions was presented to 11 psychotherapists and 90 psychology undergraduates. Both therapists and students were able to distinguish clinical and non-clinical obsession beyond chance level. It is concluded that some clinical obsessions can be identified as being evidently abnormal, and that additional theory and research is needed to identify the causes of these recognisable obsessions.     

Anxiety sensitivity within the anxiety disorders: disorder-specific sensitivities and depression comorbidity

The tendency to perceive anxious states as aversive and harmful is hypothesized to confer vulnerability to the development of anxiety disorders. The most commonly used measure of anxiety sensitivity, the Anxiety Sensitivity Index [ASI; Reiss, S., Peterson, R.A., Gursky, D.M., & McNally R.J. (1986). Anxiety sensitivity, anxiety frequency, and the prediction of fearfulness. Behavior Research and Therapy, 24, 1-8], is composed of multiple lower-order factors, assessing fear of physical symptoms, fear of publicly observable anxious symptoms, and fear of cognitive dyscontrol. This study examined the convergent validity of the lower-order anxiety sensitivity dimensions in DSM-IV diagnosed anxiety disorders. Participants with primary diagnoses of panic disorder with agoraphobia, social phobia, and generalized anxiety disorder (GAD) completed the ASI and measures of anxiety and depression severity. Support was found for the convergent validity of all ASI dimensions in reference to thematically related anxiety disorders and in the identification of patients presenting with and without secondary major depressive disorder (MDD). The ASI-fear of cognitive dyscontrol dimension displayed strong and nonredundant associations with GAD, dimensional depression scores, and secondary diagnoses of MDD. The conceptual implications of the shared importance of fear of cognitive dyscontrol in GAD and MDD are discussed.     

平板运动试验结合颈动脉斑块检测诊断冠心病

探讨平板运动试验(TET)结合颈动脉斑块检测在诊断冠心病的临床意义。对166例疑诊冠心病患者进行冠状动脉造影(CAG),TET,颈动脉斑块检查,以CAG的诊断结果为金标准,分析TET,颈动脉斑块检查,TET结合颈动脉斑块检查诊断冠心病的敏感度、特异度。比较三者诊断冠心病的敏感度、特异度。三者敏感度分别为71.4%、64.3%、96.0%。特异度分别为65%、60.0%、82.4%。后者较前两者敏感度、特异度P<0.05。TET结合颈动脉斑块检查可显著提高冠心病的诊断率,不失为CAG前的筛选方法。     

Accuracy of Self-Reported Personal History of Cancer in an Outpatient Breast Center

The self-reporting of cancer history is becoming increasingly important, as it frequently guides medical decision-making. We studied the accuracy of personal cancer history using a self-administered questionnaire, comparing the results with the Tumor Registry at our institution. Among 39,662 records, we identified 3614 women with a single cancer in the Tumor Registry who reported none or one cancer on their questionnaire. The sensitivity in self-reporting cancers was 85.7%, ranging from 92.1% for breast cancer to 42.9% for leukemia. The accuracy for breast cancer and Hodgkin's Lymphoma was significantly better than other cancers (p=0.00027, CI: 1.4–3.88). Analysis of patient's characteristics showed that Caucasians reported breast cancer more accurately than Asian/Pacific Islanders (p=0.008), and those with Jewish ancestry more accurately than non-Jewish (p=0.0435). These results will help us to improve data collection and thus improve medical decision-making.     

道德敏感性：概念理解与辨析

道德敏感性是新科尔伯格取向的重要概念,是道德行为发生之前逻辑上的心理初始成分,是对情境的道德领悟与解释,典型地反映了道德认知和道德情感的相互作用。对这个概念的性质和内涵理解存在能力观和经验观等不同观点;该概念也常操作化地为道德觉察、道德意识、后果意识、确认道德问题等;它与伦理敏感性、道德直觉等相近概念有着不同程度的区别和联系。     

Visual pathway deficit in female fragile X premutation carriers: a potential endophenotype

Previous studies indicated impaired magnocellular (M) and relatively spared parvocellular (P) visual pathway functioning in patients with fragile X syndrome. In this study, we assessed M and P pathways in 22 female fragile X premutation carriers with normal intelligence and in 20 healthy non-carrier controls. Testing procedure included visual contrast sensitivity and vernier threshold measurements. Results revealed that carriers were selectively impaired on tests of M pathways (low spatial/high temporal frequency contrast sensitivity and frequency-doubling vernier), whereas they showed intact performance on P pathway tests. These results suggest that the deficit of the M pathway is an endophenotype of fragile X syndrome.     

Environmental enrichment improves behavioral performance and auditory spatial representation of primary auditory cortical neurons in rat

Environmental enrichment (EE) has an important role in brain plasticity. Early research has shown that EE increases the response strength of neurons in the auditory cortex, but it remains unknown whether EE can influence the process of spatial localization in the auditory system. In this study, we raised rats in enriched and standard conditions from postnatal day 10 to day 56. By testing behavioral tasks via auditory cues, we have shown that EE improved the number of correct scores, but decreased the reaction time and azimuth deviation in behavioral performance of sound-azimuth discrimination. By in vivo extracellular recording, we have shown that EE enhanced the directional sensitivity of neurons in the primary auditory cortex. For example, EE rats had a smaller spatial receptive field, sharper frequency tuning curve and directional selective curve of auditory neurons compared with normal rats. Our findings indicate that early exposure to EE increases directional sensitivity. These results provide an insight into developmental plasticity in the auditory system.     

触觉空间精确性与触觉神经元密度相关联的验证

本研究应用栅栏定向任务,通过对小学一年级儿童和大学生的触觉敏感性的比较,验证触觉敏感性与神经元密度的关系。结果表明：对较大的易于分辨的刺激,成人可以完成得较好,而对较细小的难于分辨的刺激,儿童成绩更好。本研究验证了高感受单元密度对应较强的触觉敏感性的假设。     

自我损耗对利他惩罚的影响:愤怒与公正敏感性的作用

采用2个行为实验探讨了自我损耗对利他惩罚的影响。实验1采用“Stroop”任务操纵被试的自我损耗，并考察愤怒情绪在其中的中介作用；实验2使用公正敏感性量表选出高低两组被试后采用“划e”任务操纵被试的自我损耗。两个实验均用最后通牒博弈考察被试的利他惩罚行为。结果发现：高损耗组被试对不公平分配方案的拒绝比例显著高于低损耗组；愤怒情绪在两者间起部分中介作用；高公正敏感组中出现了明显了自我损耗促进效应，低公正敏感组不存在。证实了自我损耗对利他惩罚促进作用。