Zur Rekonstruktion der Philosophischen Hermeneutik

Towards a reconstruction of philosophical hermeneutics. Following Nietzsche, Heidegger and, on the other hand, Cassirer and Wittgenstein, a philosophy of interpretation, i.e. a relativism of world-views, is at present increasing in continental as well as in analytical philosophy. From the basis of a critical fallibilism the shortcomings of the new epistemological antirealism are pointed out in general, and, hence, consequences are drawn for the more specialized case of metahermeneutics (hermeneutics being defined as a sort of pragmatical semiotics). A combination of realistic and antirealistic elements is recommended as unevitable. According to this, firstly, the key-concepts of hermeneutics must be differentiated, and, secondly, a fundamental set of criteria can be established that bridges the gap between metahermeneutics and hermeneutical practice.

---

Der Artikel führt den überwiegend kritisch gerichteten Beitrag Thesen zur Philosophischen Hermeneutik, Internationale Zeitschrift für Philosophie 1993/1, 173–188 nach der konstruktiven und systematischen Seite hin weiter.     

A role for clinical psychology in health care and policy concerning the physical environment

Some persons adversely react to specific environments, while others are impervious or actually thrive. Medical attention often overlooks such sensitivities to the physical environment. Such sensitivities, including phobias and seasonal affectivity, fall within clinical psychology's purview. A theoretical/clinical approach called the Synchronous Systems Model, which defines and uses individual differences in people and in settings, could serve medical health care and policy. When specific people are matched appropriately with specific treatments within the most propitious settings, cost effectiveness and medical efficacy rise. Such documented accountability could make clinical psychologists central to triage of medical services as well as health care policy in these days of the shrinking health care dollar. The Synchronous Systems Model provides theory, supportive data, and clinical assessment devices to strengthen clinical psychology's role in medical settings.     

Systems measures of word use and differential diagnosis

This paper presents findings on the power of two systems measures of word use to discriminate four patient groups. The first is the slope of accumulated entropy or complexity of the sample (known to be logarithmic over time). The other is the average Poisson rate for the use of new words (known to be a Poisson process). The four groups consisted of cancer, depressed, paranoid, and somatization patients. The two word measures discriminate the first three groups from the fourth. There is evidence that larger samples will identify a similar discriminator for each of the first three groups from one another. The results are discussed in terms of how these methods may offer fresh insight into the relationship between language use and psychopathology.     

Familiarity and categorization processes in memory search

A fundamental distinction in tasks of memory search is whether items receive varied mappings (targets and distractors switch roles across trials) or consistent mappings (targets and distractors never switch roles). The type of mapping often produces markedly different performance patterns, but formal memory-based models that account quantitatively for detailed aspects of the results have not yet been developed and evaluated. Experiments were conducted to test a modern exemplar-retrieval model on its ability to account for memory-search performance involving a wide range of memory-set sizes in both varied-mapping (VM) and consistent-mapping (CM) probe-recognition tasks. The model formalized the idea that both familiarity-based and categorization-based processes operate. The model was required to fit detailed response-time (RT) distributions of individual, highly practiced subjects. A key manipulation involved the repetition of negative probes across trials. This manipulation produced a dramatic dissociation: False-alarm rates increased and correct-rejection RTs got longer in VM, but not in CM. The qualitative pattern of results and modeling analyses provided evidence for a strong form of categorization-based processing in CM, in which observers made use of the membership of negative probes in the “new” category to make old–new recognition decisions.     

Exploring inhibitory deficits in female premutation carriers of fragile X syndrome: Through eye movements

There is evidence which demonstrates that a subset of males with a premutation CGG repeat expansion (between 55 and 200 repeats) of the fragile X mental retardation 1 gene exhibit subtle deficits of executive function that progressively deteriorate with increasing age and CGG repeat length. However, it remains unclear whether similar deficits, which may indicate the onset of more severe degeneration, are evident in female PM-carriers. In the present study we explore whether female PM-carriers exhibit deficits of executive function which parallel those of male PM-carriers. Fourteen female fragile X premutation carriers without fragile X-associated tremor/ataxia syndrome and fourteen age, sex, and IQ matched controls underwent ocular motor and neuropsychological tests of select executive processes, specifically of response inhibition and working memory. Group comparisons revealed poorer inhibitory control for female premutation carriers on ocular motor tasks, in addition to demonstrating some difficulties in behaviour self-regulation, when compared to controls. A negative correlation between CGG repeat length and antisaccade error rates for premutation carriers was also found. Our preliminary findings indicate that impaired inhibitory control may represent a phenotype characteristic which may be a sensitive risk biomarker within this female fragile X premutation population.     

系统生物学引导阿尔茨海默病治疗新策略

阿尔茨海默病(AD)是一种发生于中老年期的退行性脑神经变性疾病,临床上以进行性智能衰退,伴有人格改变为主要特征.其发病过程涉及许多途径和靶点.现代医学认为脑内胆碱能递质功能紊乱、β-淀粉样蛋白沉积、tau-蛋白过磷酸化、炎症反应以及基因突变等在其发病过程中起着重要作用.治疗方法从胆碱酯酶抑制剂、神经递质受体阻滞剂到补气活血、益精填髓、化痰开窍等中医药疗法不等.但抑制剂、阻滞剂等药物阻滞疗法,从单一环节阻断发病途径,忽略了AD发病的整体复杂性.中医辨证论治从整体观念出发,在宏观上治疗AD,对AD的发病缺乏微观深入研究.AD治疗需要借助于“系统生物学”理论的指导.中西医结合为AD的治疗提供了较为科学、有效的途径和发展空间.     

Identifying Students at Risk: An Examination of Computer-Adaptive Measures and Latent Class Growth Analysis

Multitiered systems of support depend on screening technology to identify students at risk. The purpose of this study was to examine the use of a computer-adaptive test and latent class growth analysis (LCGA) to identify students at risk in reading with focus on the use of this methodology to characterize student performance in screening. Participants included 3,699 students in Grades 3–5. Three time points of administration (fall, winter, and spring) of the computer-adaptive reading measure were selected. LCGA results indicated 6–7 classes, depending on grade, informed by level and growth in student performance that significantly predicted failure on the statewide test administered at the end of the year. The lowest-performing classes had failure rates above 90% across all grades. The results indicate that identifying homogeneous groups of learners through LCGA may be valuable as an approach to determining students who need additional instruction. Practical implications and future directions are discussed.     

A complex dynamic systems approach to lasting positive change: The Synergistic Change Model

This paper argues that psychological and social functioning is fundamentally complex, and that this complexity is critical to understanding how lasting positive changes can be achieved. Principles from complex systems theory are integrated into an empirical positive psychological framework to propose a domain-based systems model of positive change called the Synergistic Change Model. This model proposes that enduring positive change depends on the formation of mutually supportive interactions across multiple domains of psychological and social functioning. The paper uses the model to explore three types of response to intervention – relapse, spill-over, and synergy – which have been supported in the existing positive psychology literature. Three practical intervention strategies arising from the model are outlined to inform the design of future positive interventions. The model challenges reductionistic approaches to positive change and offers several approaches to embrace the complexities of lasting positive change in future theory and research.     

Accounting for individual differences in speed in the discretized signed residual time model

With advances in computerized tests, it has become commonplace to register not just the accuracy of the responses provided to the items, but also the response time. The idea that for each response both response accuracy and response time are indicative of ability has explicitly been incorporated in the signed residual time (SRT) model (Maris & van der Maas, 2012, Psychometrika, 77, 615–633), which assumes that fast correct responses are indicative of a higher level of ability than slow correct responses. While the SRT model allows one to gain more information about ability than is possible based on considering only response accuracy, measurement may be confounded if persons show differences in their response speed that cannot be explained by ability, for example due to differences in response caution. In this paper we propose an adapted version of the SRT model that makes it possible to model person differences in overall speed, while maintaining the idea of the SRT model that the speed at which individual responses are given may be indicative of ability. We propose a two-dimensional SRT model that considers dichotomized response time, which allows one to model differences between fast and slow responses. The model includes both an ability and a speed parameter, and allows one to correct the estimates of ability for possible differences in overall speed. The performance of the model is evaluated through simulation, and the relevance of including the speed parameter is studied in the context of an empirical example from formative educational assessment.