166例冠心病患者活动平板试验中室性心律失常的分析

探讨冠心病患者冠状动脉狭窄程度与室性心律失常的关系,用Mar-quette Case16型活动平板系统测试,采用改良的Bruce方案。结果显示,偶发室早在单支狭窄和多支狭窄中无明显差异,恶性室性心律失常发生率在多支狭窄中较单支狭窄明显增高。冠心病患者出现的恶性室性心律失常提示病变严重或预后较差。     

Differential endophenotypic markers of narcissistic and antisocial personality features: A psychophysiological investigation

This study investigated the differential psychophysiological correlates of narcissistic and antisocial personality features in a college student sample. Skin conductance (SC), respiratory sinus arrhythmia (RSA), and pre-ejection period (PEP) were monitored while participants watched a countdown to an aversive noise blast and viewed emotionally valenced slides. Results indicated that narcissistic personality features were unrelated to SC reactivity during the countdown, whereas antisocial personality features were negatively related to SC reactivity. Narcissistic personality features were also related to RSA decreases and PEP shortening while viewing happy slides, whereas antisocial personality features were not. Taken together, these findings suggest differential endophenotypic markers of narcissistic and antisocial personality features despite their clinical similarities.     

Autonomic impairment in Borderline Personality Disorder: A laboratory investigation

Recent research suggests that emotional dysfunction in psychiatric disorders can be reflected in autonomic abnormalities. The present study examines sympathetic and parasympathetic autonomic nervous system activity in individuals with Borderline Personality Disorder (BPD) before, during, and following a social stressor task. Data were obtained from an analogue sample of participants screening positive for BPD (n = 12) and healthy controls (n = 28). In general, BPD participants exhibited increased sympathetic activity (indexed by Cardiac Sympathetic Index, CSI; Toichi et al., 1997) and decreased parasympathetic activity (indexed by Respiratory Sinus Arrhythmia, RSA) compared to controls. During the stressful task, BPD and control participants exhibited different trajectories of sympathetic activation: estimates of sympathetic activity increased for BPD participants and decreased for controls. Furthermore, BPD participants reported the task (but not baseline or recovery phases) to be more frustrating than controls. Findings are interpreted in the context of Polyvagal theory.     

支气管哮喘的历史回顾及哲学思考

支气管哮喘是一种常见的呼吸道疾病,到目前为止,其发病机理尚未完全阐明。在哮喘的认识过程中,经历了认识的感性阶段;变态反应性疾病阶段;气道高反应性阶段;多种细胞参与的慢性气道炎症阶段。从这个过程可以看出：１哮喘的认识经历了从现象到本质以及辩证发展的理性思维过程;２哮喘的发展过程体现了理论指导实践,实践反过来检验并丰富理论;３哮喘概念的发展体现了科学发现的一般规律。     

功能性内窥镜鼻窦外科应用的情况及问题

20世纪70年代,以慢性鼻窦炎/鼻息肉为主要治疗对象的功能性内窥镜鼻窦外科的创立和发展,开辟了鼻窦外科的新领域。功能性内窥镜鼻窦外科技术把鼻窦外科推向了新的阶段,使鼻窦炎临床治愈率提高到80%~90%,已成为国内外鼻窦炎外科治疗的主要方式。回顾功能性内窥镜鼻窦外科的发展历史,分析了鼻腔-鼻窦病变中应用的情况,并提出了应用中应处理好的两个问题,对准确把握功能性内窥镜鼻窦外科发展的趋势和特点具有重要的作用。     

Borderline personality disorder and emotion regulation: insights from the Polyvagal Theory

The current study provides the first published evidence that the parasympathetic component of the autonomic nervous system differentiates the response profiles between individuals diagnosed with borderline personality disorder (BPD) and controls. Respiratory sinus arrhythmia (RSA), a non-invasive marker of the influence of the myelinated vagal fibers on the heart, and heart period were collected during the presentation of film clips of varying emotional content. The BPD and control groups had similar initial levels of RSA and heart period. However, during the experiment the groups exhibited contrasting trajectories, with the BPD group decreasing RSA and heart period and the control group increasing RSA and heart period. By the end of the experiment, the groups differ significantly on both RSA and heart period. The correlation between the changes in RSA and heart period was significant only for the control group, suggesting that vagal mechanisms mediated the heart period responses only in the control group. The findings were consistent with the Polyvagal Theory [Porges, S. W. (1995). Orienting in a defensive world: Mammalian modifications of our evolutionary heritage: A Polyvagal Theory. Psychophysiology, 32, 301-318; Porges, S. W. (2001). The Polyvagal Theory: Phylogenetic substrates of a social nervous system. International Journal of Psychophysiology, 42, 123-146; Porges, S. W. (2003). Social engagement and attachment: A phylogenetic perspective. Annals of the New York Academy of Sciences, 1008, 31-47.], illustrating different adaptive shifts in autonomic state throughout the course of the experiment. The BPD group ended in a physiological state that supports the mobilization behaviors of fight and flight, while the control group ended in a physiological state that supports social engagement behaviors. These finding are consistent with other published studies demonstrating atypical vagal regulation of the heart with other psychiatric disorders.     

Spontaneous emotion regulation to positive and negative stimuli

The ability to regulate one’s emotions is an integral part of human social behavior. One antecedent emotion regulation strategy, known as reappraisal, is characterized by cognitively evaluating an emotional stimulus to alter its emotional impact and one response-focused strategy, suppression, is aimed at reducing behavioral output. People are capable of using these specific emotion regulation strategies when instructed to do so; however, it is equally important to investigate natural and self-selected strategy use. This study was designed to determine to what extent people spontaneously regulate their emotions and the emotion regulation strategies they choose to achieve their regulatory goals. Participants were given no instructions to regulate their emotions before they were shown a negative and a positive film clip, but were instead asked afterwards about the specific strategies that they had used. Participants reported regulating their emotions more to the negative film than to the positive film. Reappraisal was more frequently selected as an emotion regulation strategy than suppression. As expected, participants with high baseline respiratory sinus arrhythmia (RSA) adopted reappraisal strategies more than those with low RSA but, surprisingly, RSA was not associated with facial expressivity. Suggestions for future research in this relatively young field of spontaneous emotion regulation are offered.     

心房颤动的思考

从哲学角度思考心房颤动的病因、发病机制和治疗策略,有助于全面认识房颤.首先,心房颤动是由于内因和外因相互作用而导致的疾病;其次,心房颤动的发病一种从量变到质变的过程;再次,在房颤在治疗中,应该充分考虑主要矛盾和次要矛盾,选择最佳的治疗方式.用辩证的方法分析房颤的防治中出现的问题,对临床和科研工作有重要的指导意义.     

J波、fQRS、Tp-ec对ST段抬高性心肌梗死溶栓治疗后恶性心律失常的预测价值

探讨ST段抬高性心肌梗死(STEMI)患者成功溶栓治疗后J波、校正Tp-e间期(Tp-ec)、碎裂QRS波(fQRS)对恶性心律失常事件(MAE)的预测价值及其相关性.选择STEMI患者108例,成功溶栓治疗后随机分为MAE组(29例)和非MAE(NMAE)组(79例),72例正常人的心电图作为对照组.结果示MAE组J波阳性、fQRS阳性、Tp-ec≥100ms显著高于NMAE组(P＜0.05);STEMI患者Tp-ec较对照组显著延长(P＜0.05),经溶栓治疗后,Tp-ec1周和1个月时逐渐恢复,但Tp-ec仍较对照组显著延长(P＜0.05);J波阳性(OR=3.612)、fQRS阳性(OR=2.905)、Tp-ec≥100ms(OR=3.226)(均P＜0.05)与MAE的发生独立相关.以此认为J波、Tp-ec、fQRS和MAE正相关,对溶栓后MAE有预测作用.