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101.
Stress and memory: opposing effects of glucocorticoids on memory consolidation and memory retrieval 总被引:27,自引:0,他引:27
Roozendaal B 《Neurobiology of learning and memory》2002,78(3):578-595
It is well established that glucocorticoid hormones, secreted by the adrenal cortex after a stressful event, influence cognitive performance. Some studies have found glucocorticoid-induced memory enhancement. However, many studies have reported impairing effects of glucocorticoids on memory function. This paper reviews recent findings from this laboratory on the acute effects of glucocorticoids in rats on specific memory phases, i.e., memory consolidation and memory retrieval. The evidence suggests that the consequences of glucocorticoid activation on cognition depend largely on the different memory phases investigated. Posttraining activation of glucocorticoid-sensitive pathways involving glucocorticoid receptors enhances memory consolidation in a pattern highly similar to that previously described for adrenal catecholamines. Also, similar to catecholamine effects on memory consolidation, glucocorticoid influences on memory consolidation depend on noradrenergic activation of the basolateral complex of the amygdala and interactions with other brain regions. By contrast, memory retrieval processes are usually impaired with high circulating levels of glucocorticoids or following infusions of glucocorticoid receptor agonists into the hippocampus. The hypothesis is proposed that these apparently dual effects of glucocorticoids on memory consolidation and memory retrieval might be related and that the basolateral complex of the amygdala is a key structure in a memory-modulatory system that regulates, in concert with other brain regions, stress and glucocorticoid effects on both memory consolidation and memory retrieval. 相似文献
102.
Numerous previous investigators have explained species differences in spatial memory performance in terms of differences
in foraging ecology. In three experiments we attempted to extend these findings by examining the extent to which the spatial
memory performance of echidnas (or "spiny anteaters") can be understood in terms of the spatio-temporal distribution of their
prey (ants and termites). This is a species and a foraging situation that have not been examined in this way before. Echidnas
were better able to learn to avoid a previously rewarding location (to "win-shift") than to learn to return to a previously
rewarding location (to "win-stay"), at short retention intervals, but were unable to learn either of these strategies at retention
intervals of 90 min. The short retention interval results support the ecological hypothesis, but the long retention interval
results do not.
Electronic Publication 相似文献
103.
An adult California sea lion (Zalophus californianus) with extensive experience in performing discrimination learning tasks was tested to evaluate her long-term memory for two
previously learned concepts. An associative concept, that of equivalence classification, was retested after a retention interval
of approximately 1 year. The sea lion had originally shown emergent equivalence classification with nonsimilarity-based classes
of stimuli in a simple discrimination repeated-reversal procedure as well as in a matching-to-sample procedure. The 1-year
memory test revealed no decrement in classification performance in either procedure. A relational concept, that of generalized
identity matching, was retested after approximately 10 years. The sea lion had originally received trial-and-error exemplar
training with identity matching-to-sample problems prior to transferring the concept to novel stimulus configurations. In
the 10-year memory test, the sea lion immediately and reliably applied the previously established identity concept to familiar
and novel sets of matching problems. These are the first reports of long-term conceptual memory in a nonprimate species. The
experimental findings are consistent with a variety of observations of sea lions in natural settings, which indicate that
natal sites, feeding areas, and individuals may be remembered over long periods of time. Electronic Supplementary Material is available if you access this article at http://dx.doi.org/10.1007/s10071-002-0153-8. On that page (frame on the left side),
a link takes you directly to the supplementary material.
Electronic Publication 相似文献
104.
中国大学生的记忆的自我参照效应 总被引:15,自引:1,他引:14
记忆的自我参照效应是指记忆材料与自我相联系时的记忆效果优于其它编码条件的现象,这种优势主要体现在以回忆经验为特征的R反应(“记得”)上。西方一些研究表明,自我参照的记忆成绩优于参照母亲的记忆。本研究以中国大学生为被试,得到参照父亲和母亲的记忆与自我参照有同样好的成绩,显著优于参照名人的记忆,并且父母之间无差异。这支持了独立型/依赖型自我概念模型中的东方文化下的自我概念包括父母的观点。 相似文献
105.
Frontal-Lobe Involvement in Spatial Memory: Evidence from PET,fMRI, and Lesion Studies 总被引:2,自引:0,他引:2
Many studies have identified the prefrontal cortex as the brain area that is critical for spatial memory, both in humans and in other primates. Other studies, however, have failed to establish this relation. Therefore, the aim of this paper was to review the literature regarding the role of the human prefrontal lobe in spatial memory. This was done by examining the evidence obtained from neuropsychological patients and from studies using brain-imaging techniques (PET and fMRI). Evidence supporting the notion that the prefrontal cortex is extensively involved in spatial working memory was found. The majority of these studies, however, suggests that frontal-lobe involvement is not related to the type of material that is being processed (e.g., spatial vs. nonspatial), but to process-specific functions, such as encoding and retrieval. Theoretically, these functions could be linked to the central executive within Baddeley's working-memory model, or to recent theories that emphasize the various processes that play a role in working memory. Also, methodological issues were discussed. Further research is needed to enhance our understanding of the precise interaction of domain-specific and general processes. 相似文献
106.
Simkins-Bullock J 《Neuropsychology review》2000,10(1):41-74
While the intracarotid amobarbital procedure (IAP) was originally utilized to lateralize speech functions as an aid in the surgical treatment of epilepsy, additional uses for the IAP have emerged including: (1) the use of the IAP to predict post-surgical memory changes, including both global amnesia and smaller, yet significant, material-specific memory deficits; (2) the use of the IAP to provide confirmatory evidence of lateralization of seizure focus; and (3) the use of the IAP to predict post-surgical relief from seizures. While the literature on the IAP is extensive and growing, its utility is marred by the wide variability associated with the procedure itself from epilepsy center to center. This variability renders comparisons among IAP studies problematic and conclusions about IAP efficacy difficult. The variability associated with the amobarbital procedures, as well as the reliability and the validity of the IAP in its nonlanguage uses is reviewed here. A special emphasis is devoted to research conducted in the last decade. Also discussed is the future of the IAP including anticipated research directions. 相似文献
107.
We have recently reported a correlation between schizophrenialike symptoms and the degree of pseudoneglect in healthy right-handers. We aimed to investigate the effect of familial sinistrality (FS) on this relation. Seventy-six healthy right-handers were divided into four groups on the basis of gender and FS. A computerized version of Corsi's task was used as the visuospatial task. Subjects filled in the Magical Ideation Scale (MI), which asked for delusionlike beliefs, and performed the Corsi's task using each hand. Performance of both hemispaces was separately evaluated. In all groups, performance of the left hemispace was better than that of the right hemispace and FS+ subjects performed better than FS- subjects. When the right hand was used, performance was correlated to MI scores only for FS- groups. Findings suggest that the correlation between right-sided neglect and proneness to schizotypy in normal right-handers is affected by FS. 相似文献
108.
This study examined the role of global processing speed in mediating age increases in auditory memory span in 5- to 13-year-olds. Children were tested on measures of memory span, processing speed, single-word speech rate, phonological sensitivity, and vocabulary. Structural equation modeling supported a model in which age-associated increases in processing speed predicted the availability of long-term memory phonological representations for redintegration processes. The availability of long-term phonological representations, in turn, explained variance in memory span. Maximum speech rate did not predict independent variance in memory span. 相似文献
109.
Representation and working memory in early arithmetic 总被引:1,自引:0,他引:1
Working memory has been implicated in the early acquisition of arithmetic skill, but the relations among different components of working memory, performance on different types of arithmetic problems, and development have not been explored. Preschool and Grade 1 children completed measures of phonological, visual-spatial, and central executive working memory, as well as nonverbal and verbal arithmetic problems, some of which included irrelevant information. For preschool children, accuracy was higher on nonverbal problems than on verbal problems, and the best and only unique predictor of performance on the standard nonverbal problems was visual-spatial working memory. This finding is consistent with the view that most preschoolers use a mental model for arithmetic that requires visual-spatial working memory. For Grade 1 children, performance was equivalent on nonverbal and verbal problems, and phonological working memory was the best predictor of performance on standard verbal problems. For both age groups, problems with added irrelevant information were substantially more difficult than standard problems, and in some cases measures of the central executive predicted performance. Assessing performance on different components of working memory in conjunction with different types of arithmetic problems provided new insights into the developing relations between working memory and how children do arithmetic. 相似文献
110.
Three experiments investigated the roles of resource-sharing and intrinsic memory demands in complex working memory span performance in 7- and 9-year-olds. In Experiment 1, the processing complexity of arithmetic operations was varied under conditions in which processing times were equivalent. Memory span did not differ as a function of processing complexity. In Experiment 2, complex memory span was assessed under three conditions designed to vary both processing and intrinsic storage demands: mental arithmetic (significant attentional demands-requires storage), odd/even judgments (significant attentional demands-no storage required), and articulatory suppression (minimal attentional demands--no storage required). The highest memory spans were found in the articulatory suppression task. Span was at an intermediate level with arithmetic processing and was lowest for processing involving odd/even judgments. This difference in memory span for processing tasks involving arithmetic processing and odd/even judgments was eliminated in Experiment 3 when the pacing requirements of the arithmetic and odd/even processing tasks were equated. The results are consistent with the view that complex memory span performance is disrupted by processing activities that divert attentional resources from storage. 相似文献