MCM蛋白与肿瘤

微小染色体维持蛋白(MCM)是真核生物DNA复制的主要调控因子,在DNA复制的起始和延伸过程中有重要作用,在每个细胞周期中仅发生一次,是标志细胞增殖活性的新指标,对于肿瘤的诊断及预后判断有重要意义。     

The Effects of Weight Loss Attempts, Exercise Initiation, and Dietary Practices on Health Related Quality of Life

This study (N = 98) randomly placed participants in either a higher protein or American Heart Association diet group with each group initiating an aerobic exercise program. Body composition (BC) was measured using four different methodologies (DEXA, BIA, skinfold, BMI) along with height and weight, while Health-Related Quality of Life (HRQOL) changes were measured using the Medical Outcomes Short Form 36 (SF-36). There were no significant time/diet interactions in HRQOL scores, body fat measures, and weight with the exception of Role-Physical scores (p = .006) with posttest scores higher in participants in Diet 1. Role-Physical scores changed significantly in participants in Diet 1 (p = .0001) and Diet 2 (p = .026) with higher posttest scores in each group. Social functioning had a significant main effect for time in both groups with pretest scores in both diet groups lower than their respective posttest scores (p = .015). HRQOL pretest scores were not significantly different between groups at baseline (p = .56). ANOVA revealed no significant differences in average calories between groups (p = .88). Analysis revealed no differences in exercise in minutes (p = .66) nor statistically significant changes in BC or weight (p = .65). Conclusions: Improvements in HRQOL were demonstrated in two subscales related to physiological and psychological functioning. These novel findings add to literature suggesting that HRQOL, at least concerning social functioning, work and other daily activities (Role-Physical) may improve by initiating an exercise and dietary program even when weight loss or BC improvements have been unsuccessful.     

蛋白质组学与神经科学:从蛋白质到网络

多蛋白质信号复合物在所有细胞中都很重要,它们在脑内信息处理也有着重要作用。质谱、双向凝胶电泳、蛋白亲和技术、高通量的免疫组化方法和蛋白质组信息学都蛋白质组学研究的主要手段。应用蛋白质组学方法可以研究多蛋白信号复合的功能,多样性与组成的动态变化。因此,蛋白质组学发展使得人们从单个蛋白质的研究上升到对蛋白质网络的研究。蛋白质组学研究将为神经与精神疾病的诊断技术与治疗手段提供一条新的道路。