C-反应蛋白与动脉粥样硬化——谁才是始作俑者

C-反应蛋白可用于监测冠心病患者病情变化、预测冠心病的预后以及预报健康人群冠心病的发病风险。最近的研究显示,C-反应蛋白可能是动脉粥样硬化的始动因子。药物干预可以通过降低C-反应蛋白发挥抗动脉粥样硬化作用。本文分析了C-反应蛋白与动脉粥样硬化的因果关系及其在临床工作中的重要意义。     

Stress and inflammation among older adults: The moderating role of religiosity

Chronic stress weakens the immune system and leads to heightened bodily inflammation, which in turn is linked with serious health conditions. This study examined whether religiosity moderates the relationship between stress and inflammation (measured by C-reactive Protein (CRP)). A sample of 4,734 community-dwelling older adults was drawn from the 2006 wave of the Health and Retirement Study. Logistic regression was used to analyze the relationship between chronic stress (8-item index), inflammation (high CRP level), and religiosity (organizational, nonorganizational, and intrinsic), controlling for other factors. Higher levels of stress were significantly associated with high inflammation/CRP (p = .039). Further, intrinsic religiosity acted as a moderator of this relationship (p = .024), such that the relationship between stress and inflammation is lessened for persons with higher levels of intrinsic religiosity. Higher intrinsic religiosity attenuated the effects of stress on inflammation, suggesting that individuals with stronger religious commitment/motivation may better cope with stress.     

内质网应激和胰岛素抵抗

2型糖尿病的发病机制主要涉及胰岛素抵抗.近年来研究表明内质网应激可诱导胰岛素抵抗的形成,并使与改善胰岛素受体敏感性相关的内质网应激标志物分子氧调节蛋白150和转录因子X盒结合蛋白-1表达增强,表明内质网应激对细胞具有双重作用,一方面可诱导胰岛素抵抗,另一方面激发对应激的适应反应.     

剥夺左眼和单眼学习与雏鸡脑内Jun样蛋白表达的相关性研究

利用免疫组化技术,观察并比较剥夺一侧视觉及单眼一次性味觉厌恶回避学习后Ｊｕｎ样蛋白在雏鸡ＨＶ和ＬＰＯ的表达,结果表明正常雏鸡ＨＶ、ＬＰＯＪｕｎ表达几乎没有,剥夺左眼和单眼视觉学习后均可使Ｊｕｎ样蛋白增高。根据阳性神经元记数结果表明：１．视剥夺２．５、４、２４小时后可使Ｊｕｎ样蛋白的表达逐渐增高,而且它们之间的差异显著;２．剥夺左眼２小时和２４小时后训练,并分别于１０分钟、７０分钟记忆保持测验后可看到Ｊｕｎ样蛋白表达继续增多;３。无论单纯视剥夺组还是单眼视觉学习组,各组ＬＰＯＪｕｎ样蛋白的表达均明显高于ＨＶ的Ｊｕｎ样蛋白表达,它们之间差异显著。     

乳腺癌中4．1N蛋白和E-cadherin蛋白表达的临床意义

研究乳腺癌组织中4．1N 蛋白和上皮型钙黏附素（E-cadherin）的表达情况及临床病理意义。应用免疫组织化学PV-6000法和western blot法检测4．1N蛋白及E-adherin在乳腺癌中的表达。二者在乳腺癌与乳腺良性病变组织的差异有统计学意义（P＜0．05）,在乳腺癌中表达与组织学分级、临床分期、淋巴结转移有关（P＜0．05）,4．1N和E-adherin之间呈正相关。二者与浸润性乳腺癌的发生及发展相关,可为乳腺癌诊断及治疗提供参考。     

Impact of negative cognitions about body image on inflammatory status in relation to health

Objective: Evidence suggests that body dissatisfaction may relate to biological processes and that negative cognitions can influence physical health through the complex pathways linking psychological and biological factors.

Design: The present study investigates the relationships between body image satisfaction, inflammation (cytokine levels), aerobic fitness level and obesity in 96 middle-aged men and women (48 normal and 48 overweight). All participants underwent measurements of body satisfaction, body composition, serological measurements of inflammation and aerobic capabilities assessment.

Results: Body image dissatisfaction uniquely predicted inflammation biomarkers, C-reactive protein and tumour necrosis factor-α, even when controlled for obesity indicators. Thus, body image dissatisfaction is strongly linked to inflammation processes and may promote the increase in cytokines, representing a relative metabolic risk, independent of most traditional risk factors, such as gender, body mass index and intra-abdominal (waist to hip ratio) adiposity.

Conclusion: Results highlight the fact that person’s negative cognitions need to be considered in psychologically based interventions and strategies in treatment of obesity, including strategies for health promotion. Results contribute to the knowledge base of the complex pathways in the association between psychological factors and physical illness and some important attempts were made to explain the psychological pathways linking cognitions with inflammation.     

THE GENETIC RECOMBINATION OF SCIENCE AND RELIGION

The estrangement between genetic scientists and theologians originating in the 1960s is reflected in novel combinations of human thought (subject) and genes (investigational object), paralleling each other through the universal process known in chaos theory as self‐similarity. The clash and recombination of genes and knowledge captures what Philip Hefner refers to as irony, one of four voices he suggests transmit the knowledge and arguments of the religion‐and‐science debate. When viewed along a tangent connecting irony to leadership, journal dissemination, and the activities of the “public intellectual” and the public at large, the sequence of voices is shown to resemble the passage of genetic information from DNA to mRNA, tRNA, and protein, and from cell nucleus to surrounding environment. In this light, Hefner's inquiry into the voices of Zygon is bound up with the very subject matter Zygon covers.     

PRL-3在宫颈鳞癌组织中的表达及临床意义

通过RT-PCR和Western blotting来检测45例宫颈鳞癌组织和20例正常宫颈组织中PRL-3的表达情况。RT-PCR和Western blotting结果均显示宫颈鳞癌组织中PRL-3的表达明显高于正常宫颈组织(P0.01),PRL-3的表达与宫颈鳞癌组织的分化程度及淋巴转移密切相关(P0.05),而与患者年龄、肿瘤直径无关(P0.05)。因此PRL-3可能参与了人类宫颈鳞癌的发生、发展,并与宫颈鳞癌的部分临床病理特征有关,将可能作为宫颈鳞癌靶向治疗的一个新的分子靶点。     

论分子生物学时代的生理学探索——微观与宏观的统一

20世纪中期,随着蛋白质空间结构的解析和DNA双螺旋结构的发现,形成了核酸和蛋白质为主要研究对象的分子生物学时代,然而随着科学研究的不断深入微观,越来越多的科学家意识到认为将复杂的生物现象还原称简单的组成部分(细胞或分子)就能充分解释生物现象的观点有失偏颇。分子与整体,微观与宏观必须结合与统一,这一点已显得日益重要和紧迫。由此,生理学作为一门相对古老的研究结构与功能关系,尤其是整体功能的生命学科,在这一时期获得了新的契机。     

解偶联蛋白2基因启动子-866G／A多态性与2型糖尿病的相关性研究

研究解偶联蛋白-2基因启动子常见-866G／A基因多态性（UCP2—866G／A）与2型糖尿病发病相关性。用多聚酶链反应-限制内切酶长度多态性技术检测了76例非糖尿病对照（NDM）和115例糖尿病患者（DM）的UCP2—866G／A基因型分布,并分析各基因型与胰岛功能、代谢参数的差异性。结果DM的AA基因型分布显著高于NDM（32．2％vs15．8％,χ^2=6．526,P〈0．038）。在NDM组GG型携带者空腹C肽（FCP）水平高于AA和GG组（两两比较分别为t=2．99,P=0．005和t=2．229,P=0．03）;在DM各基因型之间FCP和餐后2小时C肽（2hCP）情况与NDM对照相似,各基因型混和餐刺激后2hCP差异更加明显。结论为UCP2—866G／A基因多态性与大连地区2型糖尿病发病相关,该基因多态性主要影响胰岛β细胞分泌功能。