Conceptual preference for thematic or taxonomic relations: A nonmonotonic age trend from preschool to old age

Two experiments examined the development of conceptual preference for either thematic (functional) or taxonomic relationships in a match-to sample task. In Experiment 1 twenty subjects from each of five age groups—preschool to old age—completed a method of triads preference test where they were forced to choose a thematic or taxonomic match. Young and old individuals preferred the thematic parings while school age and college adults preferred the taxonomic matches. Although the Age × Preference relation was pronounced, the majority of subjects at all ages could provide adequate justification of both the preferred and nonpreferred relationship. In addition, kindergarten subjects in Experiment 2 could readily be trained to respond on the basis of the nonpreferred mode. These data suggest that the pervasive shift in conceptual responding from syntagmatic to paradigmatic, thematic to taxonomic, etc., represents a change in preference rather than a shift to a fundamentally new way of organizing knowledge.     

Statewide Implementation of Cognitive Behavioral Therapy for Psychosis Through a Learning Collaborative Model

Cognitive Behavioral Therapy for Psychosis (CBTp) is an evidence-based psychotherapeutic intervention (EBPI) for adults with schizophrenia spectrum disorders that remains under-implemented in the United States (U.S.). There has been little empirical attention on implementation and dissemination strategies for this EBPI. The Learning Collaborative (LC) model is a method of implementing evidence-based practices across agencies and geographic regions that may facilitate CBTp implementation and dissemination in the US.We applied the LC model in an attempt to enhance the accessibility of CBTp in community mental health settings statewide. Providers (N = 56) from 12 agencies voluntarily participated in an in-person, CBTp workshop followed by 6 months of biweekly phone-based consultation sessions (Phase 1). Twenty-one providers opted to participate in an additional 6-month CBTp LC immediately following completion of the initial CBTp LC (Phase 2). Adoption, penetration, provider-perceived skill development, fidelity, as well as provider-perceived implementation barriers were re-assessed during and 6 months after completion of Phase 2.One year after the completion of the Phase 2 LC, 21% of the original trainee group across 3 of the 12 participating agencies continued to offer CBTp to clients. CBTp trainees were treating between one and two clients each. Self-assessed CBTp skills improved modestly over the Phase 2 consultation period. On average, both clinicians and supervisors reached an acceptable fidelity score on the sessions reviewed. Participating providers identified multiple barriers to CBTp implementation, including features of the training and consultation, the agency, the intervention itself, and psychosocial and clinical challenges associated with the client population.Few CBTp implementation studies have applied a framework to CBTp implementation. The authors adapted the LC model in an attempt to promote adoption of CBTp in community mental health clinics across a large, populous state with poor access to mental health services. Identified challenges and recommendations should be considered in future implementation efforts.     

第二语言阅读“熔断”假说的认知心理证据:在线篇章处理的范式

本研究以认知心理学的结构建造理论为实验框架,模拟学习者母语及外语在线篇章处理的过程,从而获取第二语言阅读"熔断"假说以及"门槛"效应的认知心理证据。英语水平差别显著的高低两组共60名被试参加了英、汉语故事理解加工实验,考察他们如何对故事的人物角色进行持续跟踪,以厘清故事内的"因果链"。结果发现:(1)高水平组成功地把他们的母语故事理解加工能力迁移到第二语言的故事理解加工,而低水平组则迁移失败;(2)理解加工能力的迁移与被试心理表征建构能力以及抑制机制的效率紧密关联,高水平组被试能有效地利用抑制机制来管理他们第二语言的结构建造过程,从而建立对故事的连贯心理表征,而低水平组则不能。在分析上述结果的基础上,文章提出第二语言阅读"熔断"假说的认知心理证据就是第二语言心理表征建构与抑制机制的作用问题;要成功地进行第二语言篇章理解,读者必须要使其二语潜在的能力(如词汇效率等)发展到某个点上,使得与抑制(结构建造的关键)相关的许多无意识的决定过程能够高度自动化。     

Behavioral profile of L‐655,708, a selective ligand for the benzodiazepine site of GABA‐A receptors which contain the α5 subunit,in social encounters between male mice

GABA‐A receptor is a transmembrane hetero‐oligomeric protein which consists of five subunits, the combination of which confers unique pharmacological properties to the receptor. It is well‐known that the GABAergic system is involved in the modulation of aggression. However, the role of α5/GABA‐A receptors has not been explored. In this study, we examined the effect of L‐655,708 (0.625‐5 mg/kg), a selective ligand for the benzodiazepine site of GABA‐A receptors which contain the α5 subunit, on agonistic behavior elicited by isolation in male mice. Individually housed mice were exposed to an anosmic “standard opponent” 30 min after drug administration, and the encounters were videotaped and evaluated using an ethologically based analysis. L‐655,708 (5 mg/kg) exhibited an ethopharmacological profile characterized by a marked reduction of the time spent in offensive behavior (threat and attack) without affecting immobility, accompanied by a significant increase of avoidance/flee and nonsocial exploration behaviors, suggesting that the antiaggressive effect of the drug is unselective. Overall, this behavioral profile might indicate the existence of an anxiogenic‐like activity of L‐655,708 in mice. Aggr. Behav. 30:319–325, 2004. © 2004 Wiley‐Liss, Inc.     

第二语言语义提取中的工作记忆效应

本文报告一项针对工作记忆容量是否制约中国英语学习者第二语言语义提取效率的实验。实验考查了工作记忆广度中的个体差异是否抑制学习者对第二语言单词语义信息的提取问题,还探索了工作记忆广度和第二语言词汇知识水平的相关性。研究以通用容量工作记忆模型为基础,采用运算广度的工作记忆测试,得出工作记忆广度对单词语义信息的提取没有显著抑制作用的结果。结果还显示工作记忆广度与第二语言词汇知识水平之间没有显著的线性关系。     

Elimination problems in logic: a brief history

A common aim of elimination problems for languages of logic is to express the entire content of a set of formulas of the language, or a certain part of it, in a way that is more elementary or more informative. We want to bring out that as the languages for logic grew in expressive power and, at the same time, our knowledge of their expressive limitations also grew, elimination problems in logic underwent some change. For languages other than that for monadic second-order logic, there remain important open problems.     

Choosing to believe

This article defends a regulative ethics of voluntary belief. In order to determine the occasion and the scope of such an ethics, the article begins with an examination of the concept of belief in conversation with the view of J. L. Schellenberg. Next, against the dominant position in contemporary epistemology, it argues that some beliefs can be voluntary, in the sense that they are under the immediate control of the believer, and replies to William Alston’s influential objections to doxastic voluntarism. If some beliefs are subject to the immediate control of the believer, then in these cases believers are ethically responsible not only for how they investigate those beliefs, but also for the choice of whether or not to believe them. The article concludes by formulating and defending two types of regulative ethical principles governing voluntary belief.     

探讨人乳头瘤病毒L1蛋白功能及其临床意义

高危型别人乳头瘤病毒（HPV）感染在宫颈癌发生发展中具有重要作用。由于HPV L1蛋白结构特征及其精确的抗原特性,在粘附宿主细胞、识别病毒受体、协助病毒DNA的入胞转运中均发挥重要作用。检测患者宫颈损伤组织中L1蛋白的表达将有助于对患者是否具有传染性进行评估。本文将深刻思考HPV L1功能及其在感染机体并引发癌变的机制,以期更好的解读宫颈癌发病原理并最终应用于,强床治疗。