Age-related Changes in Memory and Fluid Reasoning in a Sample of Healthy Old People

ABSTRACT

Participants in the Healthy Old People in Edinburgh (HOPE) study (N = 398) were assessed on Raven's Progressive Matrices and Logical Memory on up to three occasions. Covariates included education, social class, disease and medication status, blood pressure and study outcome. Raven's score declined linearly with age, whereas decline in Logical Memory was accelerating. There was significant variation in individuals' rates of decline for Ravens but not Logical Memory. Slope–intercept covariances were not significant. Those who later developed dementia already exhibited lower scores, more so for Logical Memory than Raven's. Death and study attrition were related to performance, again greater for Logical Memory. Conclusions: The HOPE approach of progressive screening is a feasible and practical method for studying healthy cognitive ageing. As predicted for an initially healthy sample, rates of decline were relatively homogeneous. The hypothesis of differential decline was not supported, nor was a strict interpretation of the hypothesis that cognitive ageing is entirely pathology driven.     

Differential Diagnosis of the Major Progressive Dementias and Depression in Middle and Late Adulthood: A Summary of the Literature of the Early 1990s

There is a preponderance of research on the neuropsychology of the various dementias. There are also direct comparisons between two or more dementias available in the literature. This paper sought to summarize the most recent literature, primarily from 1990 through mid-1996, including recent reviews of the literature from previous decades. The purpose was to provide, in one location, a summary of neuropsychological (i.e., cognitive, motor, and psychiatric) characteristics of major noninfectious, progressive dementias and depression of middle and late adulthood. It is hoped that this review, particularly a summary table provided, will serve as a guide in the differential diagnosis of the dementias by clinicians. In addition to Alzheimer's disease, vascular dementias, Parkinson's disease, Lewy body dementia, Huntington's disease, and frontal lobe dementia, the impact of depression on cognitive functioning is covered given the frequency with which neuropsychologists are asked to differentiate depression from primary dementia.     

Response persistence under ratio and interval reinforcement schedules

In Experiment 1, rats were exposed to progressive-ratio schedules of food reinforcement while other rats were exposed simultaneously to yoked-interval schedules that arranged equivalent interreinforcer intervals but required only a single response at the end of the interval for food delivery. In Experiment 2, a within-subject yoked-control procedure was employed in which pigeons were exposed to alternating sessions (one per day) of progressive-ratio schedules and yoked-interval schedules as described above. In both experiments, responding under the yoked-interval schedule persisted beyond the point at which responding under the progressive-ratio schedule had ceased. The progressive-ratio schedules controlled break-and-run distributions, and the yoked-interval schedules controlled more even distributions of responses in time. Response rates decreased and postreinforcement pauses increased over time within individual sessions under both schedules. The results suggest that responding maintained by interval schedules is more persistent than that maintained by ratio schedules. The limitations and implications of this conclusion are discussed in the context of other investigations of response strength and behavioral momentum.     

A General Approach for Fitting Pure Exploratory Bifactor Models

This article proposes a procedure for fitting a pure exploratory bifactor solution in which the general factor is orthogonal to the group factors, but the loadings on the group factors can satisfy any orthogonal or oblique rotation criterion. The proposal combines orthogonal Procrustes rotations with analytical rotations and consists of a sequence of four steps. The basic input is a semispecified target matrix that can be (a) defined by the user, (b) obtained by using Schmid-Leiman orthogonalization, or (c) automatically built from a conventional unrestricted solution based on a prescribed number of factors. The relevance of the proposal and its advantages over existing procedures is discussed and assessed via simulation. Its feasibility in practice is illustrated with two empirical examples in the personality domain.     

Graph coloring, minimum-diameter partitioning, and the analysis of confusion matrices

It is well known that minimum-diameter partitioning of symmetric dissimilarity matrices can be framed within the context of coloring the vertices of a graph. Although confusion data are typically represented in the form of asymmetric similarity matrices, they are also amenable to a graph-coloring perspective. In this paper, we propose the integration of the minimum-diameter partitioning method with a neighborhood-based coloring approach for analyzing digraphs corresponding to confusion data. This procedure is capable of producing minimum-diameter partitions with the added desirable property that vertices with the same color have similar in-neighborhoods (i.e., directed edges entering the vertex) and out-neighborhoods (i.e., directed edges exiting the vertex) for the digraph corresponding to the minimum partition diameter.     

The effects of process and outcome accountability on judgment process and performance

This article challenges the view that it is always better to hold decision makers accountable for their decision process rather than their decision outcomes. In three multiple-cue judgment studies, the authors show that process accountability, relative to outcome accountability, consistently improves judgment quality in relatively simple elemental tasks. However, this performance advantage of process accountability does not generalize to more complex configural tasks. This is because process accountability improves an analytical process based on cue abstraction, while it does not change a holistic process based on exemplar memory. Cue abstraction is only effective in elemental tasks (in which outcomes are a linear additive combination of cues) but not in configural tasks (in which outcomes depend on interactions between the cues). In addition, Studies 2 and 3 show that the extent to which process and outcome accountability affect judgment quality depends on individual differences in analytical intelligence and rational thinking style.     

汉语母语者英语动词三种屈折变化形式加工机制的差异

采用ERP技术考察了汉语母语者,英语动词三种屈折变化形式加工机制的差异。结果发现,英语动词进行式的屈折变化形式- ing的错误使用诱发了P600成分;完成式的屈折变化形式- ed的错误使用诱发了N400成分;完成式中没有明显屈折变化标识的不规则词的错误使用没有诱发典型的ERP成分。研究结果表明：对于缺乏英语使用环境、母语为汉语的晚期英语学习者来说,屈折变化形式- ing,完成式规则动词的变化形式- ed和没有明显形态变化标识的不规则动词的变化形式具有不同的加工机制,前者可能处于由陈述性记忆系统向程序性记忆系统加工的转变过程中,而后两者更多地由陈述性系统进行加工。这种加工机制的差异可能与动词屈折变化规则的复杂程度有关。     

进展性脑卒中诊治及相关因素分析

进展性脑卒中是缺血性脑血管病最常见的一个临床现象,进展性脑卒中的存在严重影响卒中患者的预后。迄今为止,关于其流行病学资料、发病机制、诊断标准、治疗均是极具挑战性的问题。进展性脑卒中可能是多种原因、多种病理机制所产生的多种状态的组合,治疗的手段应该以开放动脉或通过全身治疗的方法来增加脑灌注压为主。     

论新时期医学院校人文学科建设

加强医学人文学科建设是全面推进素质教育、培养创新精神的重要内容,也是深化医学教育改革步伐的重要举措.医学院校开展医学人文教育教学真正目的是进一步优化高等医学院校人才培养模式,使医学人文学科知识内化为医学生的人文思想和人文精神.     

晚期喉癌患者的个体化治疗和心理干预

晚期喉癌患者往往伴有严重的心理负担。这种负性心理状态因疾病的特殊性以及患者本身个体就医背景的差异而产生有别于其他癌症的个体特征。把握患者的个体负性心理状态,运用相应的心理干预措施,使患者的期望和医生的治疗目的趋向统一,将有助于晚期喉癌个体化治疗模式的有效实施。