Slowly progressive pure dysgraphia with late apraxia of speech: a further variant of the focal cerebral degeneration

We report a longitudinal neuropsychological investigation of a patient with slowly progressive pure dysgraphia. Cognitive analysis of writing errors suggested a selective impairment of the graphemic buffer. After about seven years, the patient developed an apraxia of speech. No other linguistic or generalized cognitive impairment occurred subsequently, so that, twelve years after the beginning of the disease, the patient showed complete independence in daily life and still remained professionally active. Functional neuroimaging revealed hypoperfusion confined to left fronto-temporal lobe. This well-recognizable syndrome does not fit any of the cases described previously in the literature. This report therefore, adds another variant to heterogeneous clinical spectrum of focal neurodegenerative disorders, further suggesting the opportunity of their distinction from pathological processes leading to dementia.     

On the way to autonomous driving: How age influences the acceptance of driver assistance systems

Driver assistance systems have the potential to create the basis for future mobility solutions. They enable older generations in need of assistance to maintain their mobility even in the case of physical deficits. Therefore, we conducted a literature review and identified factors that may influence the acceptance of driver assistance systems. Based on the technology acceptance model and other influencing factors, we developed a research model that was validated with the help of a study (n = 227). The results show that, depending on age, there are differences in the acceptance of driver assistance systems and their influencing factors among old and young people. The five determinants of acceptance, perceived usefulness, perceived ease of use and trust in technology are viewed as equally important for all age groups. Differences emerge within the group of older vehicle drivers with varying weighting. For the 50–59 age group, perceived ease of use and social norm are most important, while for the 60–69 age group, perceived usefulness and trust in technology are very important. Among 70–90-year olds, trust in technology is emphasized as most important. Our results show how important it is to increase the confidence of older drivers in age-appropriate driver assistance systems, using target-group-specific advertising and public relations work.     

Difficulties experienced by older drivers during their regular driving and their expectations towards Advanced Driving Aid Systems and vehicle automation

The aim of this study was to analyse the difficulties experienced by older drivers during their regular driving, and to identify their needs and their expectations regarding Advanced Driving Aid Systems (ADAS) and vehicle automation. More than 100 items were investigated by using a Focus Group method based on a Collective Questionnaire (named FoG-CoQS). Thirty elderly drivers, 15 females and 15 males aged from 70 to 81 years (mean age of 73.3; S.D. = 3.18) were recruited among a representative sample of 76 older drivers living in the Rhône area and having previously participated to an on-road experiment, in order to collect from this Focus Group method further information about the driving difficulties they experienced in their everyday life and their expectations towards driving aids. Seven main topics were more particularly investigated, recovering at last all the main dimensions of the driving task (from navigation to speed control, through intersection crossing).Regarding driving difficulties, one of the most interesting result collected is the high contrast between the literature review, identifying Left Turn (LT) manoeuvres at crossroads as a risky driving situation for elderly drivers, and the relatively low values of perceived difficulties (i.e. compared to other driving sub-tasks) collected during this Focus Group among our sample of older drivers. Regarding the driving aid functions investigated, 10 of them obtained high scores of “perceived utility” (i.e. overpassing 60% on scales ranging from 0% [no utility] to 100% [high utility]), and they concerned assistances liable to support all the main components of the driving task investigated in this study.Additional results are related to the differences between the elderly female and male drivers. Several driving situations were assessed as significantly more difficult to perform by the older female than by the older male drivers, like intersection crossing, entering expressways, or implementing a lane change manoeuver. By contrast, this gender effect is more limited regarding driving aids: synthetically, men and women have a positive attitude towards driving aid systems and their expectations for future ADAS are quite similar (for instance, “informative systems” are preferred than driving aids based on “vehicle automation”).Finally, from two transversal items (i.e. “difficulties” to perform a driving sub-task and “perceived utility” of ADAS), it was possible to rank older drivers’ difficulties experienced during their everyday life (from lowest difficulties to “navigate on a familiar itinerary” to highest when “interacting with bicyclists”) and their expectations towards driving aids (from lowest utility score given to “Automatic Lane Change systems” to highest utility value provided to “Speed Informer systems”). At last, older drivers’ acceptance and expectations towards highly automated cars was also investigated: full automation was assessed as an interesting solution to ensure the self-mobility of elderly peoples in their circle, but also for themselves in the future, in case of impairments of their own cognitive or physical capacities.     

Decision making and visibility in cats (Felis catus) in a progressive elimination task

When making decisions animals can rely on information stored in memory and/or on information available through perceptual processes. Under some circumstances, perceptual access to a relevant piece of information can be lost as when a prey hides under a cover. If this piece of information is critical, the animal must be able to keep it active in the working memory until the final decision is made. Species endowed with object permanence can to a certain extent overcome such a lack of perceptual access. Numerous studies have investigated object permanence in animals, but no study systematically examined the interaction when making a decision between an information directly available through perception and an information that can no longer be perceived. In the present study, domestic cats (Felis catus) were administered a progressive elimination task in which they had to visit and deplete either two visible and one hidden target (e.g., Experiments 1 and 2) or one visible and two hidden targets (e.g., Experiments 3 and 4). The cats were brought back to the starting point after each visit to any target whether that target had been previously visited or not. The results revealed that the cats searched at the visible target(s) first and at the hidden target(s) last, which was referred to as the visibility rule. The results also revealed that the position of the bowl that was distinct (e.g., the visible bowl when the two other ones were hidden and the opposite) influenced the way this cognitive rule was implemented. More specifically, when the intermediate bowl was distinct the visibility rule was readily implemented but when either the right of the left bowl was distinct the visibility was violated. That is the cats did no longer choose the visible target(s) first. The visibility rule was interpreted in terms of optimization principles, the external distinct target effect was interpreted in terms of divided attention and lateralization.     

Grit and conscientiousness: Another jangle fallacy

When grit was first introduced, it gained popularity before basic psychometric questions were fully explored. One critical issue is how distinct grit is from the Big Five personality trait conscientiousness. Most studies have examined correlations between grit and conscientiousness, rather than conducting item-level factor analysis. This study examined the extent to which grit and conscientiousness are empirically distinct, and which predict students’ grades. A diverse sample of adolescents completed measures of grit and conscientiousness. MIRT-based confirmatory factor analyses showed that grit and conscientiousness’ factor structures strongly overlap. Structural equation modeling showed that conscientiousness and the perseverance of effort component of grit predicted students’ grades more strongly than consistency of interest. These findings indicate that grit and conscientiousness are not unique constructs.     

Longitudinal assessment of short‐term memory deterioration in a logopenic variant primary progressive aphasia with post‐mortem confirmed Alzheimer's Disease pathology

In the field of dementia research, there are reports of neurodegenerative cases with a focal loss of language, termed primary progressive aphasia (PPA). Currently, this condition has been further sub‐classified, with the most recent sub‐type dubbed logopenic variant (PPA‐LV). As yet, there remains somewhat limited evaluation of the characteristics of this condition, with no studies providing longitudinal assessment accompanied by post‐mortem examination. Moreover, a key characteristic of the PPA‐LV case is a deterioration of phonological short‐term memory, but again little work has scrutinized the nature of this impairment over time. The current study seeks to redress these oversights and presents detailed longitudinal examination of language and memory function in a case of PPA‐LV, with special focus on tests linked to components of phonological short‐term memory function. Our findings are then considered with reference to a contemporary model of the neuropsychology of phonological short‐term memory. Additionally, post‐mortem examinations indicated Alzheimer's disease type pathology, providing further evidence that the PPA‐LV presentation may reflect an atypical presentation of this condition.     

Make this detour and be unselfish! Influencing urban route choice by explaining traffic management

Traffic management policies aim to improve traffic flow by influencing the route choice of drivers, therefore preventing traffic jams in crowded cities. With respect to a system-optimum of the traffic network, drivers might have to make small-scale detours. The aim of this article is to encourage unselfish route choice behaviour in an urban context by informing drivers in advance about the objectives of traffic management. Two studies were conducted: (1) an online survey (N = 244) and (2) a driving simulation study (N = 48). The first study focussed on the general effect of recommendations for routes with longer travel times (system-optimal routes) when traffic management is explained. Other route choice attributes (travel time, red-light duration, time pressure) were analysed as well. Drivers were randomly confronted with 35 route choice scenarios consisting of a main route with certain red-light duration and an alternative route without. Results showed that the compliance with system-optimal routes is increased by around 10 percentage points when comparing the group with recommendation to the group without. This effect occurred independently of the variation of other route choice attributes. The second study aimed to determine if the compliance can be increased even more if drivers receive in-depth information about traffic management and experience ‘good’ as well as ‘bad’ recommendations in a driving simulator. Results showed no further effect of these manipulations on route choice. Only decision-making times and subjective evaluation were influenced by in-depth information compared to basic information. Altruism was partly correlated with decision-making. This article shows a novel approach to encouraging drivers to select routes with longer travel times for the benefit of the common good. Drivers’ knowledge gap regarding traffic management needs to be closed in order to enhance their understanding of traffic regulations. Finally, results of this research should be transferred to driver models within traffic simulations to estimate the effects on traffic networks.     

The role of mathematical skill in sex differences on Raven’s Matrices

This study replicated a previously reported male advantage on certain items of Raven’s Matrices and found no sex differences in performance on other items. We refer to the latter as analytic (1) items and the former as analytic (2) items. Reasons for the male advantage were investigated by correlating scores obtained by male and female high school students on analytic (1) and analytic (2) items with their scores on tests of spatial, verbal and mathematical ability. There were no sex differences in the magnitude of the correlations between scores on analytic (2) items and the two spatial and verbal tests. In contrast, males but not females showed a significantly higher correlation of maths with analytic (2) than with analytic (1). The results suggest the Raven’s Matrices may engage different, more specific cognitive processes in males and more general cognitive processes in females.     

晚期乳腺癌的非手术治疗进展

晚期乳腺癌患者的治疗一直存在争议。不同治疗方案优势人群的选择仍有待细化和确认,以便将“个体化治疗”的概念落到实处。新药的开发为我们带来更多的选择,但是经济条件的限制,带来的临床问题更需我们冷静思考。相信通过不断的尝试和努力,定会获得进一步的突破。     

Benefits and Interindividual Differences in Children's Responses to Extended and Intensified Relaxation Training

The present study investigates whether extended and intensified systematic relaxation training techniques lead to increased short-term and prolonged effects in settings of stress prevention. One hundred and twenty-eight fourth- and sixth-graders (aged 9.6 and 11.6 years, respectively) participated in Imagination or Progressive Muscle Relaxation (PMR). Extension consisted of a varying number of training sessions (five versus ten), while intensified training contained additional training elements to enhance the transfer to the children's daily life (yes versus no). Age, gender, anxiety, activity level and suggestibility were included as additional variables that were assumed to moderate the effects of the training. Dependent variables indicating short-term training effects included physiological parameters (heart rate, skin conductance level, skin temperature) as well as subjective ratings (mood, physical well-being, training evaluations). Medium-term training effects, measured 1 week and 2 months after the training, were related to stress experiences, somatic stress symptoms, and coping strategies reported by the children. The results do not show considerable short- or medium-term effects of extended or intensified training. In addition, no clear moderator effects were found in the present sample.