Self-awareness and self-monitoring of cognitive and behavioral deficits in behavioral variant frontotemporal dementia, primary progressive aphasia and probable Alzheimer's disease

Lack of insight is a core diagnostic criterion for behavioral variant frontotemporal dementia (bvFTD), and is believed to be intact in the early stages of primary progressive aphasia (PPA). In other neurological conditions, symptom-specific insight has been noted, with behavioral symptoms appearing especially vulnerable to reduced insight. Different components of insight, self-awareness and self-monitoring, are also often considered separate phenomena. The current study compared insight in patients with PPA, bvFTD, and probable Alzheimer's disease (PrAD) and a group of cognitively intact control subjects. Additionally, differences in insight for the domains primarily affected by the three types of dementia, namely, Behavior, Naming, and Memory, were assessed, and self-awareness and self-monitoring were compared. A total of 55 participants were enrolled. Participants were asked to complete self-estimate scales demonstrating their perceived ability immediately prior to, and immediately following a test in each domain of interest. Results indicated that PPA and normal control groups performed very similarly on control (Weight and Eyesight) and cognitive domains, whereas bvFTD and PrAD patients were unable to accurately assess Memory. All three diagnostic groups failed to accurately assess their behavioral symptoms, suggesting that this domain is vulnerable to loss of insight across diagnoses. Naming ability, in contrast, was either accurately assessed or underestimated in all groups. Finally, there were no notable differences between self-awareness and self-monitoring, potential explanations for this are examined.     

Systems marketing: a new operating model for pharmaceutical marketing

This paper introduces a new model for marketing based on systems design. Adaptive tactical systems are featured as a novel commercial approach that enables ROI to be measured holistically, and serves as a comprehensive strategy for progressive integration, accommodating new marketing components, on‐demand technologies, and business ideas as they emerge and are added to the same containing whole. Initially applied to the pharmaceutical industry, the paper details the design and evolution of a brand module, a tactical system focused specifically on harvesting top‐line sales from primary care brands in a middle market of the United States. Copyright © 2005 John Wiley & Sons, Ltd.     

A re-examination of the algebraic properties of the AHP as a ratio-scaling technique

The Analytic Hierarchy Process (AHP) ratio-scaling approach is re-examined in view of the recent developments in mathematical psychology based on the so-called separable representations. The study highlights the distortions in the estimates based on the maximum eigenvalue method used in the AHP distinguishing the contributions due to random noises from the effects due to the nonlinearity of the subjective weighting function of separable representations. The analysis is based on the second order expansion of the Perron eigenvector and Perron eigenvalue in reciprocally symmetric matrices with perturbations. The asymptotic distributions of the Perron eigenvector and Perron eigenvalue are derived and related to the eigenvalue-based index of cardinal consistency used in the AHP. The results show the limits of using the latter index as a rule to assess the quality of the estimates of a ratio scale. The AHP method to estimate the ratio scales is compared with the classical ratio magnitude approach used in psychophysics.     

Early electro-cortical correlates of inspection time task performance

The concept of general intelligence (g) summarizes the well established finding that scores on separate cognitive tasks are positively correlated, indicating a trait common to many aspects of information processing. Inspection time is a well-established correlate of IQ, where those of a higher IQ can correctly identify a briefly presented stimulus with a greater level of accuracy than those of a lower IQ. This study used two age-matched samples, selected on the basis of their scores on Raven's Advanced Progressive Matrices from the undergraduate population of Bangor University. In order to address the confound of inspection time and IQ of previous ITT-ERP research, each participant of the presented study performed an IT task with the same five levels of stimulus duration while undergoing 64-channel EEG recording. The high IQ group made significantly fewer errors at each level of stimulus duration and exhibited a significantly larger N1 response. N1 latency and other ERP components did not distinguish the two IQ groups. Given the specificity of ERP group differences to the N1, the results of the present study suggest that the link between IT performance and g is attributable to individual differences in directing attention to a spatial region.     

进修人员在双向转诊中作用的研究

我国人口分布范围广,医疗资源主要集中在大、中城市,合理利用有限的医疗资源,解决看病难,看病贵,实现有效转诊,是我们当前面临的一个难题。研究显示：通过进修医生转诊率高,迅速,患者及家属满意率高;对符合转诊要求,需要下转的患儿100例通过进修人员下转患者率96％,直接下转率65％。由此可见通过进修医生对患者进行双向转诊效果...     

晚期非小细胞肺癌化疗的冷思考

晚期非小细胞肺癌提倡以化疗为主综合治疗,可以延长生存期,提高生存率。但目前化疗取得的疗效虽然较既往有提高,但提高生存期有限,且在药效经济学方面存在争议,缓解症状的作用也有限,联合靶向治疗的疗效也在观望中。临床肿瘤学工作者应正确认识,以循证医学为指导,开展规范化化疗,同时也注重个体化化疗,并期待晚期非小细胞肺癌化疗的新突破。     

Surprisingly Neuroplastic Human Brains: Reading,Science, Philosophy,Theology

Human brains, dramatically more complex than anything else in the known universe, are marvelously mutable. Recent neuroscience focuses on how humans create cumulative transmissible cultures which in turn shape mental development. When cultures become literate, cognitive powers escalate. Although until recently only a comparative few learned to read and write, this takes place with the serendipitous re-use of pattern recognizing capacities, such as those for recognizing faces. With sustained reading diligence, as required during education in science, philosophy, and theology, this results in advanced cognitive skills.     

Mapping the Terrain of a Foucauldian Ethics: A Response to the Surveillance of Schooling

Educators find themselves in the midst of arising tide of urban school reform marked byevermore centrally designed and monitoredsystems of accountability. In response to thislooming high-stakes gaze of surveillance, thisessay offers an ethics of educationalleadership predicated upon taking up thechallenge of creatively and courageouslyauthoring one's ethical self. It seeks tocontribute to mapping an ethical terrain whichcan support the production of pedagogicalpractices, initiatives, and agendas asdistinctive, bold responses to theproliferation of one-dimensional,technicist-driven efforts which narrowlycalculate and assess student learning, teacherwork, school effectiveness, and which offeranemic, foreclosed readings of a possiblefuture. My claim is that a consideration ofFoucault's ethics draws us closer torecognizing what such a project would mean andask of the educator as leader.     

Topics of Marital Conflict in the Everyday Lives of Empty Nest Couples and Their Implications for Conflict Resolution

To improve our understanding of marriage experiences during midlife, diary reports of naturalistic marital conflict were collected from 55 couples who were parents of grown children who had left the home. Communication, chores, and habits were the most frequent sources of disagreements reported by husbands and wives. Hierarchical linear models tested the unique associations between multiple conflict topics and interaction characteristics (length, recurrence, initiator, and importance) and constructive, angry, and depressive resolution strategies. Husbands and wives similarly rated money and habits as recurrent topics and conflicts concerning money and children as holding relatively high levels of current and long-term importance to the relationship. Compared with other topics, husbands and wives consistently perceived conflicts concerning habits and communication as being handled in relatively angry ways (e.g., defensiveness) and marital conflicts about children as eliciting greater depressive conflict (e.g., withdrawal, sadness). Husbands also viewed conflicts concerning relatives and commitment as being handled in relatively depressive ways. The findings explicate substantive sources of midlife marital disagreements and offer future research and clinical directions.