医学伦理审查如何适应转化医学的要求

随着转化医学的兴起,医学伦理审查面临前所未有的机遇与挑战.如何使医学伦理审查工作更好地适应转化医学发展的需要,提高审查质量,成为亟需解决的问题.在分析当前我国医学伦理审查工作现状和主要问题的基础上,进一步探讨了可行的解决方法,如进一步明确和强化管理部门服务功能、保证伦理委员会成员多样性和重视伦理审查多视角、强化伦理委员会后续跟踪审查、规范伦理审查委员的培训与继续教育等,为我国医学伦理审查工作的规范化发展和医学伦理审查质量的进一步提高提供参考.     

艾滋病科研设计的伦理思考

艾滋病严重地影响着人类的健康及生活质量,艾滋病相关因素的研究迫在眉睫,其科研中包含着一系列的伦理问题,如艾滋病患者的依从性问题,艾滋病患者进行试验研究的双盲、随机、对照等原则问题及艾滋病患者科研相关质量问题.要深刻地理解和认识这些伦理问题,在艾滋病科研设计中注意理解和尊重受试者,制定出有效而合乎伦理的科研政策,加强交流,从而得到艾滋病患者和家属以及社会的认同,以有利于在不同范围内进行科研合作.     

全世界最早的病毒研究机构——弗里德里希·勒夫勒研究院

弗里德里希·勒夫勒研究院(Friedrich-Loeffler-Institut,FLI)由弗里德里希·勒夫勒于1910年创建,是全世界最早开展病毒研究的机构.FLI的使命是关注家畜卫生,研究人畜共患疾病.其主要职能除了研制口蹄疫病、经典猪瘟等动物疾病的一些疫苗外,还为传染性疾病做诊断.FLI在德国6个地方设有10个分支机构,总部设在Riems岛,岛上设有4个研究所;Jena设有2个研究所;Brunswick有1个研究所;Mariensee有1个研究所;Celle有1个研究所;Wuster hausen有1个研究所.FLI的标志人物是弗里德里希·勒夫勒,他是德国著名的微生物学家、卫生学家、病毒学建立者之一,开辟了免疫学,尤其是白喉的治疗等.     

护理学专业学位硕士研究生临床实践体验研究

采用质性研究中的现象学研究方法,对来自全国各地10所院校的12名护理学专业学位研究生进行半结构式深度访谈。通过对录音访谈内容进行三级编码,逐步归纳提炼出三个主题,每个主题下涵盖不同的副主题：（1）临床实践获益感方面：提升核心能力、体现自身价值;（2）心理体验：归属感、失落感;（3）影响临床实践效果的瓶颈因素：缺乏明确的临床能力考评标准、临床带教师资队伍薄弱。因此,教育者和管理者应重视专业学位硕士研究生,晦床核心能力培养,构建一个充满人文关怀的临床实习环境,消除瓶颈因素,以提高其临床实践效果。     

School‐based humanistic counselling for psychological distress in young people: A practice research network to address the attrition problem

Aims: School‐based humanistic counselling (SBHC) is a common psychological intervention for young people, particularly in the UK. However, studies have tended to suffer from high attrition rates, such that effects may have been over‐estimated. This paper describes a low budget ‘star topology’ practice research network (PRN) outcome evaluation of SBHC in a sample where attrition rates were minimised. Design: A practice‐based longitudinal study in a small PRN compared levels of psychological distress at first and last session from session‐by‐session data. Multilevel regression modelling was used to identify predictors of outcomes. Methods: Eight counsellors working across 11 schools agreed to use session‐by‐session self‐rating on the Young Person's CORE (YP‐CORE) yielding data from 256 young people aged 11 to 17. Predictors of outcomes were analysed using multilevel regression analysis. Results: Mean levels of distress on the YP‐CORE reduced from 18.29 (SD = 7.32) at baseline to 9.10 (SD = 6.19) at endpoint, giving a baseline to endpoint effect size of 1.26 (95% CI = 1.06–1.46). Lower levels of psychological distress at endpoint were associated with male clients, younger age groups, greater rates of attendance at counselling, and bereavement as a presenting problem. Conclusions: This ‘star topology’ PRN focused on a single study and demonstrated that such a system can provide relatively low cost, high quality data. The data showed that SBHC is associated with large reductions in psychological distress, and that this cannot be attributed to the high attrition rates of previous datasets.     

A Mixed‐Method Examination of Preschool Teacher Beliefs About Social–Emotional Learning and Relations to Observed Emotional Support

The connections between parents' socialization practices and beliefs about emotions, and children's emotional development have been well studied; however, teachers' impacts on children's social–emotional learning (SEL) remain widely understudied. In the present study, private preschool and Head Start teachers (N = 32) were observed using the Classroom Assessment Scoring System. Comparison groups were created based on their observed emotional support and then compared on their qualitative responses in focus group discussions on beliefs about emotions and SEL strategies. Teachers acknowledged the importance of preparing children emotionally (as well as academically) for kindergarten, but substantial differences emerged between the highly emotionally supportive and moderately emotionally supportive teachers in three areas: (1) teachers' beliefs about emotions and the value of SEL; (2) teachers' socialization behaviours and SEL strategies; and (3) teachers' perceptions of their roles as emotion socializers. Understanding such differences can facilitate the development of intervention programs and in‐service training to help teachers better meet students' SEL needs. Copyright © 2014 John Wiley & Sons, Ltd.     

The meaning of the h-index

The h-index originates from the assumption that the number of citations received by a scientist is a better indicator of the relevance of his or her work than the number of papers he or she publishes or the journals where they are published. It takes into account the number of papers published and the citations to those papers in a balanced way, and thus is useful to make comparisons between scientists. The present paper addresses the most frequent questions about the h-index. Specifically, it explains its origin, its advantages compared to other indices, the factors that can influence it (e.g. age, field of knowledge, topic of research and language of publication), its variants, and the injustices it may lead to. In short, this paper provides a clear exposition of the hoped-for role of the h-index in the evaluation of scientists: that it serves as a useful complement to other indicators that are more subjective, and that it contributes to the progress of science by aiding decision-making on allocation of research resources in a more effective way, and on rewarding researchers who contribute to scientific progress in a more fair way.     

The psychological process of reintegration following a nine month/260 day solo sailboat circumnavigation of the globe

The focus of this case report is on the psychological reintegration process following the achievement of a highly challenging long‐duration and solitary endeavor. The participant was a 29 year old male who successfully circumnavigated the globe during a 260 day solo sailing expedition. We assessed the psychological aftermath in terms of stability and change in personality characteristics and personal beliefs prior to, and at 180 and 360 days after the completion of the journey. Overall, the personality configuration reflected adaptive personality functioning. A belief in an internal locus of control was consistent throughout, as were perceptions of personal growth as a result of the circumnavigation experience. NEO PI‐R Neuroticism, Extraversion, Openness, and Triarchic Psychopathy Measure (Tri‐PM) Boldness scores remained stable. Positive personality change was reflected by an elevation in Conscientiousness; negative change by a decline in Agreeableness and an increase in Tri‐PM Disinhibition. While overall the participant exhibited positive change as a result of his journey, there were also some negative aspects of the reintegration phase in regard to interactions with other persons. This latter change may be related to the effects of isolation from usual social contacts over an extended period.     

Entitlement,exploitativeness, and reasoning about everyday transgressions: A social domain analysis

Social domain theory was used to examine the role of entitlement and exploitativeness in reasoning about everyday transgressions in two studies. Exploitativeness was positively associated with believing that transgressing was acceptable, whereas entitlement was negatively associated. Exploitive participants justified these judgments using personal (e.g., appeal to choice) and less moral (e.g., appeal to welfare of others) reasoning, whereas highly entitled people used more prudential but less personal reasoning. Exploitive participants were less likely to acknowledge the relevance of non-personal concerns (i.e., morality, conventions, and prudence) when considering transgressions. The association between exploitativeness and acceptability of transgressing was mediated by the degree to which issues were believed to involve a concern for others. Implications for narcissistic behavior and decision-making are discussed.