P16、CyclinDl和CDK4在结直肠癌组织中表达及意义

细胞周期过程中癌基因的激活与抑癌基因的失活等是造成细胞恶性增殖、转化的重要因素。细胞周期G1／S期各调节因子的异常改变与细胞癌变关系尤为密切。P16、CyclinDl和CDK4均为重要的细胞周期调控蛋白,任何原因导致这些蛋白异常表达时,将引起细胞周期调节失控,导致肿瘤的发生和恶性演进。结直肠癌的发生发展同上述三者关系密切。本实验通过免疫组化方法进行检测结直肠癌组织中P16、CyclinDl和CDK4三者的表达及其与结直肠癌临床指标的关系,为揭示三者在结直肠癌发生发展中的作用提供一定的实验依据。     

Two in one or one in two? Pushing off from Jung with Wolfgang Giegerich

This paper responds to a recent paper by Wolfgang Giegerich entitled ‘Two Jungs: apropos a paper by Mark Saban’. Giegerich disputes my assertion that the ‘rigorous notion’ at the heart of his psychology ‘finds no source in Jung's psychology, implicit or explicit’. In order to do this he posits the existence of two Jungs, an exoteric Jung and an esoteric Jung. The implications of Giegerich's binary scission of Jung are explored in this paper, and show that the tendency to exalt one Jung while disparaging the other betrays a comprehensive blindness toward the contradictory complexity of Jung's psychology as a whole. It is suggested that this blindness is the consequence of Giegerich's systematic prioritization of a neo‐Hegelian agenda that is in profound conflict with the telos of Jung's psychology.     

Standing in the gap: ref lections on translating the Jung‐Neumann correspondence

This paper considers the experience of translating the correspondence between C.G. Jung and Erich Neumann as part of the Philemon series. The translator explores the similarities between analytical work and the task of translation by means of the concepts of the dialectical third and the interactional field. The history and politics of the translation of analytic writing and their consequences for the lingua franca of analysis are discussed. Key themes within the correspondence are outlined, including Jung and Neumann's pre‐war exploration of Judaism and the unconscious, the post‐war difficulties around the publication of Neumann's Depth Psychology and a New Ethic set against the early years of the C.G. Jung Institute in Zurich, and the development of the correspondents’ relationship over time.     

No evidence of risk-taking or impulsive behaviour in a person with episodic amnesia: Implications for the role of the hippocampus in future-regarding decision-making

Does advantageous decision-making require one to explicitly remember the outcome of a series of past decisions or to imagine future personal consequences of one's choices? Findings that amnesic people with hippocampal damage cannot form a clear preference for advantageous decks over many learning trials on the Iowa Gambling Task (IGT) have been taken to suggest that complex decision-making on the IGT depends on declarative (episodic) memory and hippocampal integrity. Alternatively, impaired IGT performance in amnesic individuals could be secondary to risk-taking and/or impulsive behaviour resulting from impaired episodic future thinking (i.e. prospection) known to accompany amnesia. We tested this possibility in the amnesic individual K.C. using the IGT and the Toronto Gambling Task (TGT), a novel task that dissociates impulsivity from risk-taking without placing demands on declarative memory. K.C. did not develop a preference for advantageous over disadvantageous decks on the IGT and, instead, showed a slight preference for short-term gains and an inability to acquire a more adaptive appreciation of longer-term losses. He also did not display impulsive or risk-taking behaviour on the TGT, despite a profound inability to imagine personal future experiences. These findings suggest that impaired decision-making on the IGT in amnesia is unlikely to reflect a predilection to act in the moment or failure to take future consequences into account. Instead, some forms of future-regarding decision-making may be dissociable, with performance on tasks relying on declarative learning or on episodic-constructive processes more likely to be impaired.     

Psychosis,symbol, affectivity 2: another perspective on the treatment of psychotic disorder

This is the second of two papers concerning our study into an integrated approach to psychotic disorders conducted at the University Psychiatry Unit of Palermo’s Polyclinic over approximately 15 years; this paper concentrates on the clinical phenomena. The study aimed to find the best possible treatment and to improve the prognosis of this patient group. We have explored the efficacy of a range of psycho-therapeutic (cognitive-behavioural, systemic-relational, psychodynamic, group and others), psycho-pharmaceutical, psychiatric rehabilitative and psycho-educational treatments, with a hermeneutic approach instead of a systematic one. The study’s conclusions, described in the paper, are that all psychotic functions start with a nuclear psychic issue connected to emotional development. We describe how the most significant symptoms of acute psychotic manifestations (delusions and misperceptions) make use of an encrypted psychological meaning that can be decoded through the patient’s symbolic language. This language is a key element in diagnosis and in the choice of treatment. The paper describes how we revised our understanding of psychosis from being a brain disease to being a process aimed at the rearrangement of psychic functioning. Our significant results are described.     

La fundamentación psicológica de una estética musical: la obra de Carl E. Seashore

Resumen

La figura del psicólogo sueco-norteamericano Carl Emil Seashore (1866–1949) no suele ser hoy demasiado recordada. Fue sin embargo un autor importante, de extensa y variada obra, que ejerció en vida una considerable influencia académica y social y cuyos puntos de vista resultan extraordinariamente representativos de una cierta manera de entender la psicología que no ha dejado de tener adeptos desde entonces. Sus propuestas estéticas, además, son todavía hoy dignas de conocerse y discutirse.

El propósito de este trabajo es recuperar estas propuestas como una invitación a reflexionar sobre las relaciones entre la psicología y la estética, unas relaciones que Seashore se esforzó notablemente por dotar de claridad y precisión. Para ello se trazan primero algunas de las coordenadas históricas y biográficas que enmarcan su obra y desde las cuales ésta cobra sentido. Se pasa después a dibujar los grandes rasgos de su investigación psicológica sobre la música, para terminar analizando la concepción estética que su autor aspira a fundar en ella. Unas breves consideraciones críticas vienen a poner el punto final a este estudio.     

Incarnation and Semiotics: A Theological and Anthropological Hypothesis Part 1: Incarnation and Peirce's Taxonomy of Signs

This is the first in a pair of articles in which we draw on C.S. Peirce's semiotics (theory of signs) to develop a new approach to the Christian concept of Incarnation. In this article (Part 1) we use Peirce's taxonomy of signs to explore what it means to understand the life of Jesus as the embodiment of the quality of the life of God within the fabric of the created order. In Part 2, we explore some ways in which this semiotic approach to the Incarnation offers constructive opportunities in theological anthropology and suggests some empirically testable hypotheses about human evolution.     

Globalisation,society and religion: from mono‐metastructural theory to metatheoretical reflexivity

Examining globalisation theories, Eduardo Mendieta has come to the conclusion that there is a conceptual link between religion and social theory when theorising globalisation. His preference is for metatheoretical reflexivity type theories of globalisation that, in contrast with mono‐metastructural and matrix rearrangement theories, incorporate conceptual reflection on ‘religion’. With this typology in mind, the work of Ninian Smart and Wilfred Cantwell Smith, two authors in the study of religion for whom the era of globalisation was a central element in developing their views on religion and the study of religion, will be compared. Whereas Smart's views do not fundamentally break away from mono‐metastructural type theories, Smith's work, although highly problematic, gives some hints for developing a meta‐theoretical reflexivity type theory of religion, society and globalisation.