结核病诊治进展与科技革命

现代科技革命极大地促进了结核病各方面的发展.微生物学和免疫学的发展,揭示了结核病的病因、发病机制、病理生理的本质,分子生物学技术使结核病的基础研究不仅停留在器官、细胞水平,而是深入到蛋白质、核酸、基因的水平;基因治疗的方法可望从根本上治疗结核病.高新技术的产物如X线照片、电子计算机断层扫描、纤维支气管镜检查和新药的出现等极大地提高了临床诊治的能力.借助于各种先进的医疗设备而进行精确的诊断,基因治疗将成为一种崭新的治疗手段.     

What will the future bring? Thoughts of children after missile bombardment

Abstract

We examined how cognitive views of the future relate to degree of exposure to trauma and to posttraumatic stress reactions in children. Following the experience of Scud missile bombardment during the Persian Gulf war, 492 Israeli pupils from grades 5, 7, and 10 from regions actually hit and from regions under threat but not hit, described what they thought life would be like next year for children of their age. Based on recent cognitive theories, it was expected that children who experienced higher levels of stress would also express more pessimistic views of the future. We found that children's dominant perception of the future was positive. However, children who expressed stronger postwar reactions also tended to have more pessimistic future views, especially in areas that were hit by missiles. Discussion focused upon views of the future as a direct consequence of the stress as well as a means of coping with stress.     

Correspondence between children's and adults' ratings of stimulant-induced changes in ADHD behaviours in a crossover trial with medication-naive children

Correspondence between children's and adults' ratings of changes in ADHD behaviours was investigated in a paediatric ADHD stimulant crossover trial. Thirty-one children completed an ADHD self-report scale each week, and comparisons were made with an ADHD questionnaire completed by adults (combined parent and teacher ratings). Children's and adults' ratings demonstrated good internal consistency, were significantly associated with the assessment of ADHD behaviours in the placebo condition and showed comparable responsiveness to stimulants at the group level. Furthermore, a large and significant correlation was detected between the two sets of informants' ratings of changes from placebo to both methylphenidate and dextroamphetamine high-dosage conditions, but not from placebo to low-dosage conditions. Agreement in the categorization of best stimulant condition for individual children was significant, but modest from a clinical perspective. The results indicate that children's ratings correspond adequately with adults' ratings, and thus appear to be a complementary outcome measure.     

Differential impacts of age of acquisition on letter and semantic fluency in Alzheimer's disease patients and healthy older adults

The degree to which the typical age of acquisition (AoA) of words and word frequency have separable influences on verbal production tasks has been strongly debated. To examine the overlap between these factors in verbal fluency tasks, the performance of Alzheimer's disease (AD) patients (N?=?34) and normal elderly controls (N?=?36) was compared on semantic (e.g., vegetables) and letter (e.g., words that begin with F) fluency tasks. These comparisons revealed that words generated for the semantic fluency task had an earlier AoA while words generated for the letter fluency task had a higher word frequency. Differences in AoA between AD patients and controls were larger for semantic than letter fluency. These results suggest that AoA has an effect on verbal production that is independent of word frequency and that AoA has a semantic locus.     

Sport and the obligation of solidarity

The paper departs from an analysis of the case of Michelle Dumaresq, a transgender female downhill mountain biker who experienced marginalization within her sport. The analysis is based on Axel Honneth’s theory of recognition. The Dumaresq case is particularly relevant to Honneth’s ideas of solidarity, which provide insight into the dynamics of social integration. Honneth’s theory of recognition also provides a conceptual framework and a methodology that gives new perspectives on the ethical significance of sport. In the paper, an analysis is presented of the lack of solidarity experienced by Dumaresq. The argument is made that sport has a particular potential for realizing solidarity among its practitioners. Realizing solidarity however depends to a large degree upon that the rules of sport are perceived as fair and just. In the Dumaresq case, challenges to solidarity came from what her competitors considered to be unfair classification rules. Summing up, it is argued that, as long as the rules of a sport is perceived as fair and just, voluntary engagement gives rise not only to obligations on fair play but to a moral obligation on solidarity as well.     

Consider the Children

Summary

In this article, we consider interventions for children exposed to family violence in light of the research on children's problems associated with witnessing family violence. Next, we review risk and protective factors related to these children's adjustment with the view that all children are not similarly affected by exposure to family violence. Against this background, we then move to consider directions for interventions from a systemic perspective. We take into account not only the exposure to interactions between their mother and father, but also children's relationships with their mother, father, and siblings, as well as within broader systems such as the peer group, the school, and the community. We consider the critical challenges within each of these important systems for children exposed to family violence, and we propose some potential interventions to address the problems. Finally, we summarize an evaluation of an intervention that incorporates some of the elements identified by a systemic perspective. The evaluation revealed a significant improvement in children's self-reports of depression and anxiety over the course of the program. Mothers rated their children as significantly improved in emotional and hyperactive behaviour problems. There was no relation between mothers' involvement in counselling and children's improvement. Overall, the results suggest that the Peer Group Counselling Program effectively provided support to children exposed to family violence. Finally, we discuss the steps necessary to support children and families in moving toward violence-free lives.     

The "Perceptual Wedge Hypothesis" as the basis for bilingual babies' phonetic processing advantage: new insights from fNIRS brain imaging

In a neuroimaging study focusing on young bilinguals, we explored the brains of bilingual and monolingual babies across two age groups (younger 4-6 months, older 10-12 months), using fNIRS in a new event-related design, as babies processed linguistic phonetic (Native English, Non-Native Hindi) and nonlinguistic Tone stimuli. We found that phonetic processing in bilingual and monolingual babies is accomplished with the same language-specific brain areas classically observed in adults, including the left superior temporal gyrus (associated with phonetic processing) and the left inferior frontal cortex (associated with the search and retrieval of information about meanings, and syntactic and phonological patterning), with intriguing developmental timing differences: left superior temporal gyrus activation was observed early and remained stably active over time, while left inferior frontal cortex showed greater increase in neural activation in older babies notably at the precise age when babies’ enter the universal first-word milestone, thus revealing a first-time focalbrain correlate that may mediate a universal behavioral milestone in early human language acquisition. A difference was observed in the older bilingual babies’ resilient neural and behavioral sensitivity to Non-Native phonetic contrasts at a time when monolingual babies can no longer make such discriminations. We advance the “Perceptual Wedge Hypothesis” as one possible explanation for how exposure to greater than one language may alter neural and language processing in ways that we suggest are advantageous to language users. The brains of bilinguals and multilinguals may provide the most powerful window into the full neural “extent and variability” that our human species’ language processing brain areas could potentially achieve.     

Managers’ selection preferences: The role of prejudice and multicultural personality traits in the assessment of native and immigrant job candidates

PresentationStatistics across European countries show that immigrants have a disproportionate lower employment probability than persons born in the host country (SOPEMI, 2010). Explanations to this phenomenon are complex.ObjectivesAn experiment was conducted to investigate the relationship between multicultural personality traits and managers’ selection preferences in the hiring of native vs. foreign-born job candidates. We proposed that this relationship was mediated by prejudice.MethodsNorwegian managers (n = 222) were presented with one Turkish immigrant job candidate and two Norwegian-born, less qualified job candidates. The managers completed the Multicultural Personality Questionnaire (MPQ) and the Blatant Prejudice Scale (SBPS).ResultsWe found that the threat and rejection blatant prejudice subscale and Emotional stability predicted the managers’ hiring preferences. Specifically, the higher threat and rejection subscale scores and the lower emotional stability scores, the more likely it is that the managers preferred to hire a native, less qualified candidate over the Turkish immigrant candidate. The effect of emotional stability on candidate preference was not mediated by prejudice.ConclusionsThe results suggest that managers’ feelings of threat due to foreign-born immigrants’ participation in the host society (political conservatism), and threat due to intercultural interactions, are significantly related to foreign-born immigrant job candidates’ chances of being hired.     

近十年来我国儿童孤独感的研究现状与展望

儿童孤独感是儿童觊觎自己对同伴关系与友谊质量的自我知觉而产生的一种消极的、弥漫性的主观情绪体验。近十年来,国内学者开始关注留守儿童、学业不良儿童的孤独感,探讨同伴关系、认知因素、家庭环境、师生关系以及社会支持等因素对儿童孤独感的影响,但缺乏适合本土化的儿童孤独感的量表;探讨单一因素对孤独感的研究较多,多因素交互作用对孤独感的影响的较少;调查研究较多,追踪研究较少。今后,将创建适合我国本土化的儿童孤独感量表并注重横断与追踪研究相结合的方法,儿童孤独感将会趋于追踪研究的发展并会构建出适合我国儿童孤独感的干预方案。