The Inconsolable Doll Task: Prenatal coparenting behavioral dynamics under stress predicting child cognitive development at 18 months

Studies have demonstrated that coparenting can be assessed prenatally through playful observational conditions, including simulated baby enactments. Regrettably, there is a lack of empirical research examining how prenatal coparenting under the emotional stress elicited by the distress of a simulated infant predicts children’s cognitive development. The current longitudinal study introduces a novel procedure—the Inconsolable Doll Task—to assess prenatal coparenting behavioral dynamics under the stress of a non-responsive doll simulator, and examines the extent to which prenatal interaction patterns predict the child’s cognitive development at 18 months. The sample consists of 105 community-based, co-living, expectant fathers and mothers. Data were collected prenatally, at three, six, and 18 months in home and lab visits. Results indicate that the prenatal coparenting dynamic of negative escalation explains a unique variance in children’s cognitive development at 18 months. This effect is evident even when accounting for both prenatal and postnatal assessments of low-stress coparenting behavioral patterns or self-reported coparenting perceptions, and when controlling for parental education. These findings are discussed in terms of their methodical, empirical, and clinical implications.     

Fetal Testosterone,Socio‐Emotional Engagement and Language Development

The present study investigated the relations among fetal testosterone, child socio‐emotional engagement and language development in a sample of 467 children (235 boys) from the Western Australian Pregnancy Cohort (Raine) Study. Bioavailable testosterone concentration measured in umbilical cord blood taken at birth was found to be significantly negatively correlated with socio‐emotional engagement and vocabulary development for boys but not for girls. Socio‐emotional engagement mediated the effect of boys' fetal testosterone levels on their vocabulary development. However, the size of the effects was small, and fetal testosterone and socio‐emotional engagement were no longer significant predictors of boys' vocabulary scores after accounting for the effects of other predictors including maternal age and education, parity, and parent–child book reading. It is concluded that further research into these associations is warranted in both typical and atypical development and that this research would profit from including a broader focus on the role that proximal processes such as socio‐emotional engagement, joint attention and imitation have in mediating the developmental effects of prenatal factors such as fetal testosterone exposure. Copyright © 2012 John Wiley & Sons, Ltd.     

Digit Ratio 2D:4D,facial masculinization and aggressiveness in Spanish adolescents / Índice 2D:4D,masculinización facial y agresividad en adolescentes españoles

Abstract

This study aims to test whether two morphometric characteristics, the second to fourth finger length ratio (2D:4D index) and the facial width-to-height ratio (FWH index), which reflects the degree of facial masculinization, are related to aggression in adolescents of both sexes. Previous studies have proposed that the 2D:4D index (a trait related to prenatal testosterone) and the FWH (related to testosterone during puberty) are related to aggressiveness in adult males (although there is evidence to the contrary). In the present study we investigate the relationship of both traits with different measures of aggression in a mixed population of 296 adolescents (14–19 years old). We did not find relationships between 2D:4D and FWH with aggressiveness. Furthermore, our results suggest that the FWH index must be used only after controlling for body mass index.     

Neuroprotective Effects of Testosterone on Regenerating Spinal Cord Motoneurons in Rats

Degeneration in the CNS and peripheral nervous system consists of degradation and phagocytosis of axons and their myelin sheath distal to the site of injury. Testosterone is a gonadal sex steroid hormone that plays an important role in CNS development. One of the lesser-known testosterone actions is neuroprotection. In the present study, the authors investigated the neuroprotectective effect of intracerebral ventricular injection of testosterone on the number of spinal motoneurons after sciatic nerve crush. In all, 32 male Wistar rats were divided to 4 groups (control, compression, compression + castration, compression + testosterone injections; n = 8). Four weeks after compression the lumber segments of spinal cord were sampled, processed, sectioned serially, and stained with toluidine blue (pH = 4.65) by using steriological quantitative technique (physical dissector), the number of alpha motoneurons in the right ventral horns of spinal cord were counted and compared between groups. Statistical analyses showed that testosterone injections (1μl icv, 4 times, 1 week interval between injections) significantly (p < .05) reduced neuronal damage. These results indicated that testosterone has an obvious neuroprotective effect on lumbar spinal motoneurons.     

Higher functioning children with prenatal alcohol exposure: Is there a specific neurocognitive profile?

Recent attempts to identify a neurocognitive profile of children with prenatal alcohol exposure (PAE) have led to an emerging “generalized deficit” conceptualization marked by diffuse information processing and integration difficulties as opposed to a specific profile. This study examines whether this conceptualization can be extended to higher functioning children with PAE who are without intellectual disability and addresses several limitations of previous research. One hundred twenty-five children aged 6–12 years with social skills deficits, 97 of whom met diagnostic criteria for a Fetal Alcohol Spectrum Disorder (FASD), underwent a comprehensive, multi-informant assessment of neurocognitive, emotional, social, behavioral, and adaptive functioning. Multivariate analyses of variance examined differences in functioning between the PAE group and a nonexposed comparison group with and without controlling for child IQ. Results indicated that the PAE group returned significantly poorer scores than the nonexposed group on every construct assessed, including executive functioning, attention, working/visuospatial memory, linguistic abstraction, adaptive behavior, emotional/behavioral functioning, and social cognition. These differences largely maintained after controlling for IQ and were similar regardless of informant, although teachers reported somewhat fewer group differences. Within the PAE group, no differences were found across FASD subtypes. These results provide evidence extending the emerging generalized deficit conceptualization of children with PAE to those higher functioning individuals without global intellectual disability.     

Prenatal SSRI exposure: Effects on later child development

The aim of this review is to integrate research on the pharmacological mechanisms of selective serotonin reuptake inhibitors (SSRIs) and the following effects on fetal brain development and child cognitive function seen in children with prenatal exposure to SSRIs. As antidepressants are transferred from the mother to the fetus through the placenta, the fetus is vulnerable to alterations in neurotransmission and possibly altered neural functioning. Because of this risk, pregnant women suffering from depression are often advised to discontinue their use of antidepressants during pregnancy. Though, maternal untreated depression may also have negative consequences for the fetus and child after birth. In the present review, we find a distinction between studies of early versus late development. Studies on early cognitive development indicate no negative effects, while studies on later development report some cognitive difficulties and behavioral problems, indicating latent effects of exposure. However, the reviewed studies are not all converging, and it is not clear whether and to what extent prenatal SSRI exposure affects cognitive development.     

Improvements in Unmarried African American Parents' Rapport,Communication, and Problem‐Solving Following a Prenatal Coparenting Intervention

This report examines effects of a coparenting intervention designed for and delivered to expectant unmarried African American mothers and fathers on observed interaction dynamics known to predict relationship adjustment. Twenty families took part in the six‐session “Figuring It Out for the Child” (FIOC) dyadic intervention offered in a faith‐based human services agency during the third trimester of the mother's pregnancy, and completed a postpartum booster session 1 month after the baby's arrival. Parent referrals for the FIOC program were received from a county Health Department and from OBGYNs and Pregnancy Centers in the targeted community. All intervention sessions were delivered by a trained male–female paraprofessional team whose fidelity to the FIOC manualized curriculum was independently evaluated by a team of trained analysts. At both the point of intake (“PRE”) and again at an exit evaluation completed 3 months postpartum (“POST”), the mothers and fathers were videotaped as they completed two standardized “revealed differences” conflict discussions. Blinded videotapes of these sessions were evaluated using the System for Coding Interactions in Dyads. Analyses documented statistically significant improvements on 8 of 12 variables examined, with effect sizes ranging from moderate to large . Overall, 14 families demonstrated beneficial outcomes, 3 did not improve, and 3 showed some signs of decline from the point of intake. For most interaction processes, PRE to POST improvements were unrelated to degree of adherence the paraprofessional interventionists showed to the curriculum. However, better interventionist competence was related to decreases in partners' Coerciveness and Negativity and Conflict, and to smaller increases in partner Withdrawal. Implications of the work for development and delivery of community‐based coparenting interventions for unmarried parents are discussed.     

The impact of prenatal serotonin reuptake inhibitor (SRI) antidepressant exposure and maternal mood on mother–infant interactions at 3 months of age

Exposure to maternal depression increases risks for altered mother–infant interactions. Serotonin reuptake inhibitor (SRI) antidepressants are increasingly prescribed to manage antenatal maternal illness. The impact of SRIs on early mother–infant interactions was unknown. Three-month-old infants of 32 depressed mothers treated with SRI medications during pregnancy and 43 non-medicated mothers were studied. Using an established face-to-face mother–infant interaction paradigm, dyad interactions were studied with and without a toy. Videotaped sessions yielded 4 measures: maternal sensitivity, dyadic organization, infant readiness to interact, and maternal interruptive behaviors. Even with prenatal SRI treatment, depressed mothers interrupted their infants more during toy play. In the absence of prenatal SRI treatment, maternal postnatal depression adversely influenced infant behavior. Higher levels of maternal depression symptoms at 3 months predicted poorer infant readiness to interact during the toy session. Conversely, in the SRI-exposed group, higher prenatal depression scores predicted greater infant readiness to interact at 3 months. Increased infant readiness with SRI exposure suggests a “fetal programming effect” whereby prenatal maternal mood disturbances shaped a future response to a postnatal depressed maternal environment.     

Prenatal predictors of maternal and newborn EEG

Ninety-two mothers were recruited at a prenatal ultrasound clinic at which time they were given the CES-D for depression and the State-Trait Anxiety Inventory, and their urines were assayed for cortisol, norepinephrine, epinephrine, dopamine, and serotonin. At the neonatal period the mothers and neonates were assessed on frontal EEG asymmetry. Correlation analyses revealed the following: (1) the mothers’ frontal asymmetry was negatively related to prenatal depression (CES-D) symptoms, negatively related to prenatal norepinephrine levels and positively related to prenatal serotonin levels; (2) the frontal asymmetry of the newborn was positively correlated with the mothers’ frontal asymmetry and negatively correlated with the mothers’ prenatal depression (CES-D) symptoms and negatively correlated with the mothers’ prenatal state anxiety scores. The neonates’ EEG frontal asymmetry was also, like the mother's, negatively related to prenatal maternal norepinephrine and positively related to prenatal maternal serotonin.     

Born gay? The psychobiology of human sexual orientation

Sexual orientation is fundamental to evolution and shifts from the species-typical pattern of heterosexuality may represent biological variations. The growth of scientific knowledge concerning the biology of sexual orientation during the past decade has been considerable. Sexual orientation is characterised by a bipolar distribution and is related to fraternal birth order in males. In females, its distribution is more variable; females being less prone towards exclusive homosexuality. In both sexes homosexuality is strongly associated with childhood gender nonconformity. Genetic evidence suggests a heritable component and putative gene loci on the X chromosome. Homosexuality may have evolved to promote same sex affiliation through a conserved neurodevelopmental mechanism. Recent findings suggest this mechanism involves atypical neurohormonal differentiation of the brain. Key areas for future research include the neurobiological basis of preferred sexual targets and correlates of female homosexuality.