丙酸睾丸酮对MCF－7荷瘤裸鼠肿瘤生长的影响及临床意义

观察不同剂量丙酸睾丸酮对MCF-7荷瘤裸鼠肿瘤生长的影响,并探讨其可能机制和临床意义。构建MCF-7荷瘤裸鼠,再用不同浓度的丙酸睾丸酮（50mg／kg,400mg／kg）及化疗药物（表阿霉素）进行干预,比较各组实验鼠肿瘤的生长情况,并用微粒子发光法检测裸鼠血清睾丸酮的含量,用流式细胞技术检测肿瘤中雄激素受体的表达。发现...     

杨时易学思想考论

杨时主要继承了二程的易学思想,注重从义理释<易>,同时也认同画前元有易,推崇先天学,融义理、象教为一炉.然而,杨时的易学旨趣却在于用易,不流于空谈易理.他主张反身而诚,学<易>必须心通的为学之方.由于受到当时学术背景和社会政冶的影响,杨时的易学思想理论建构并未超出前人范畴,但其易学思想在易学史上也有着重要地位和影响.     

Prenatal depression effects and interventions: A review

This review covers research on the negative effects of prenatal depression and cortisol on fetal growth, prematurity and low birthweight. Although prenatal depression and cortisol were typically measured at around 20 weeks gestation, other research suggests the stability of depression and cortisol levels across pregnancy. Women with Dysthymia as compared to Major Depression Disorder had higher cortisol levels, and their newborns had lower gestational age and birthweight. The cortisol effects in these studies were unfortunately confounded by low serotonin and low dopamine levels which in themselves could contribute to non-optimal pregnancy outcomes. The negative effects of depression and cortisol were also potentially confounded by comorbid anxiety, by demographic factors including younger age, less education and lower SES of the mothers and by the absence of a partner or a partner who was unhappy about the pregnancy or a partner who was depressed. Substance use (especially caffeine use) was still another risk factor. All of these problems including prenatal depression, elevated cortisol, prematurity and low birthweight and even postpartum depression have been reduced by prenatal massage therapy provided by the women's partners. Massage therapy combined with group interpersonal psychotherapy was also effective for reducing depression and cortisol levels. Several limitations of these studies were noted and suggestions for future research included exploring other predictor variables like progesterone/estriol ratios, immune factors and genetic determinants. Further research is needed both on the potential use of cortisol as a screening measure and the use of other therapies that might reduce prenatal depression and cortisol in the women and prematurity and low birthweight in their infants.     

Prenatal dysthymia versus major depression effects on the neonate

Depressed pregnant women were classified as dysthymic or major depression disorder based on the Structured Clinical Interview for Depression and followed to the newborn period. The newborns of dysthymic versus major depression disorder mothers had a significantly shorter gestational age, a lower birthweight, shorter birth length and less optimal obstetric complications scores. The neonates of dysthymic mothers also had lower orientation and motor scores and more depressive symptoms on the Brazelton Neonatal Behavioral Assessment Scale. These findings were not surprising given the elevated cortisol levels and the inferior fetal measures including lower fetal weight, fetal length, femur length and abdominal circumference noted in our earlier study on fetuses of dysthymic pregnant women.     

Offspring Effects of Prenatal Alcohol Exposure from Birth to 25 Years: The Seattle Prospective Longitudinal Study

Before alcohol was generally known to cause birth defects, NIAAA in 1974 began funding a population-based Seattle study on alcohol use and pregnancy outcome. Women receiving prenatal care by mid-pregnancy were recruited (N = 1,529) and interviewed at home. Approximately 500 offspring exposed to a range of alcohol levels were examined on 11 occasions between day 1 and 25 years. Neuropsychological and neurobehavioral performance measures are correlated with prenatal alcohol dose, without substantial confounding by socio-demographic or rearing conditions, smoking, nutrition, or other drugs. Deficits in attention, arithmetic skill, spatial-visual memory, and IQ, as well as increased alcohol problems and psychiatric disorders are among offspring outcomes correlated at several ages with maternal drinking during and before pregnancy recognition. Findings are not confined to women who believed they had alcohol problems. Not all exposed offspring appear affected.     

Associations of Maternal Prenatal Smoking with Early Childhood Physical Aggression,Hyperactivity-Impulsivity,and Their Co-Occurrence

This study investigated associations between maternal prenatal smoking and physical aggression (PA), hyperactivity-impulsivity (HI) and co-occurring PA and HI between ages 17 and 42 months in a population sample of children born in Québec (Canada) in 1997/1998 (N=1745). Trajectory model estimation showed three distinct developmental patterns for PA and four for HI. Multinomial regression analyses showed that prenatal smoking significantly predicted children’s likelihood to follow different PA trajectories beyond the effects of other perinatal factors, parental psychopathology, family functioning and parenting, and socio-economic factors. However, prenatal smoking was not a significant predictor of HI in a model with the same control variables. Further multinomial regression analyses showed that, together with gender, presence of siblings and maternal hostile reactive parenting, prenatal smoking independently predicted co-occurring high PA and high HI compared to low levels of both behaviors, to high PA alone, and to high HI alone. These results show that maternal prenatal smoking predicts multiple behavior regulation problems in early childhood.     

Foetal testosterone and vocabulary size in 18- and 24-month-old infants

Amniotic fluid, obtained from 87 pregnant women for routine amniocentesis, was analysed for foetal testosterone (FT) level. Their infants (40 girls and 47 boys) were followed up 18 and 24 months after birth and their vocabulary size was assessed. Girls were found to have a significantly larger vocabulary than boys at both ages. This replicates previous findings of a female advantage in language ability, but reveals this sex difference at the earliest point of development. Additionally, FT was an inverse predictor of vocabulary size when data from both sexes was examined together, but not within sex. The lack of a significant correlation between FT and vocabulary within each sex may reflect the relatively small sample size. However, the significant correlation between FT and vocabulary when the sexes were combined suggests FT might be involved in shaping the neural mechanisms underlying communicative development.     

Prenatal testosterone treatment potentiates the aggression‐inhibiting effect of the neurosteroid dehydroepiandrosterone in female mice

The neurosteroid dehydroepiandrosterone (DHEA) is a powerful inhibitor of aggression in murine models when given for 15 days and potentially may be useful in the management of inappropriate human aggression. Although the biosynthesis and metabolism of DHEA have been described, little is known about the potential effect of the steroidal environment during sexual differentiation on the subsequent response to DHEA. Whether prenatal androgen exposure influences the subsequent response to DHEA was assessed by comparing the effect of DHEA (80 μg/d) on aggression in female offspring where dams were treated with 1, 10, or 100 μg of testosterone (T) on days 15 to 18 of gestation (Experiment I) or that developed in different uterine positions (Experiment II). The results showed that DHEA decreased attack behavior in general and that the 100‐μg prenatal T treatments enhanced the antiaggressive effect of this neurosteroid. Neither the lower doses of exogenously administered T nor the uterine position led to an enhanced response to DHEA. In addition, whether DHEA produced changes in social and nonsocial activities was examined. In the 100‐μg T females, DHEA increased the duration of the former and decreased the frequency and duration of the latter, indicating that it was not a general decrement in behavioral expression that mediated the enhanced response to the antiaggressive effect of DHEA. In the second experiment, DHEA treatment led to increased frequencies of social nonaggressive and nonsocial activities. However, the uterine positions × treatment interactions were not significant, demonstrating that contiguity to male fetuses did not differentially affect the response to DHEA. Aggr. Behav. 27:130–138, 2001. © 2001 Wiley‐Liss, Inc.     

睾酮与人类攻击行为

睾酮是一种可以在男性的睾丸间质细胞、女性卵巢和胎盘的皮层细胞中合成并分泌的雄性激素, 它可以调节个体的各种生理、形态和行为过程, 对个体生存和繁殖至关重要。大量研究表明, 睾酮与社会行为的关联存在双向性, 睾酮可以调节社会行为, 社会行为可以反馈并进一步影响睾酮水平。我们将关注点聚焦于睾酮与人类攻击行为之间的关联。早期研究发现, 高睾酮水平个体表现出更高的攻击性; 近期的研究根据挑战假设理论模型和生物社会地位模型得出, 人体内的睾酮水平对竞争性相互作用具有高度反应性。此外, 通过对大量研究的回顾与分析, 我们总结出睾酮水平的变化可以通过增强杏仁核的反应性或减少前额叶皮质-杏仁核功能耦合来影响攻击行为。未来的研究者应考虑其他激素(如皮质醇)和人格特征调节睾酮和人类攻击行为之间关系的潜在作用, 以及相关的生物学机制。     

Maternal distress during pregnancy and language development in preschool age: A population-based cohort study

Recent studies have emphasized the importance of the prenatal period for children's cognitive development. Prenatal exposure to psychological distress has been identified as one potential agent affecting neurodevelopment, although research in this area has been marked by some contradictory findings and methodological limitations. This study aimed to investigate the effect of maternal distress during pregnancy on language development of preschool children. This study was based on the Norwegian Mother and Child Cohort Study conducted at the Norwegian Institute of Public Health. The sample was composed of 34,089 women and their children. We assessed the role of maternal prenatal distress on child language over and above that of premature low birth weight (PLBW) status and postnatal maternal distress. Fear of giving birth had a negative impact on language outcome at age three over and above the effect of PLBW status and postnatal maternal distress. However, this effect was of minimal magnitude. Moreover, when examining whether differences in language skills between siblings were associated with differences in experienced levels of prenatal stress across pregnancies (sibling fixed-effects models), no significant effects were found. Our study suggests that prenatal distress within moderate limits does not seem to have an independent impact on child language performance in the preschool years and emphasizes the importance of considering the contextual role played by more stable maternal and family characteristics.