Partial replication of two rumination-related candidate gene studies

Two recent papers associated candidate genes with brooding rumination, a possible cognitive endophenotype for depression, in children ages 8–14 years. Stone et al. reported that BDNF val66met polymorphism predicted brooding in adolescence. Woody et al. reported that children carrying at least one copy of a CRHR1 TAT haplotype reported less brooding than their peers in the presence of maternal depression. We attempted to replicate and extend these findings in a sample of twins aged 12–16 years. We analyzed the BDNF val66met (rs6265) polymorphism and two (rs242924 and rs7209436) out of three single nucleotide polymorphisms (SNPs) that Woody et al. used to create a CRHR1 haplotype. We controlled for maternal history of depression and clustering within families. Unlike Stone et al., we found higher brooding among BDNF Met carriers. This main effect was qualified by an interaction with pubertal status, with the effect driven by more physically mature participants. Similar to Woody et al., we found an interaction between CRHR1 SNPs and maternal depression, with the homozygous minor genotype acting as a protective factor against brooding in the presence of maternal depression. Findings provide partial support for the influence of candidate genes in two environmentally sensitive systems on brooding.     

Individual differences in cognitive control over emotional material modulate cognitive biases linked to depressive symptoms

Deficient cognitive control over emotional material and cognitive biases are important mechanisms underlying depression, but the interplay between these emotionally distorted cognitive processes in relation to depressive symptoms is not well understood. This study investigated the relations among deficient cognitive control of emotional information (i.e. inhibition, shifting, and updating difficulties), cognitive biases (i.e. negative attention and interpretation biases), and depressive symptoms. Theory-driven indirect effect models were constructed, hypothesising that deficient cognitive control over emotional material predicts depressive symptoms through negative attention and interpretation biases. Bootstrapping analyses demonstrated that deficient inhibitory control over negative material was related to negative attention bias which in turn predicted a congruent bias in interpretation and subsequently depressive symptoms. Both shifting and updating impairments in response to negative material had an indirect effect on depression severity through negative interpretation bias. No evidence was found for direct effects of deficient cognitive control over emotional material on depressive symptoms. These findings may help to formulate an integrated understanding of the cognitive foundations of depressive symptoms.     

‘It was all intertwined’: Illness representations and self-management in patients with cancer and anxiety/depression

Objective: Cancer and anxiety/depression frequently co-occur, leading to poorer outcomes for these illnesses. However, the majority of existing research investigates how participants view single illnesses alone. This study aimed to explore the content of individuals’ multimorbid representations and how these relate to their coping behaviours and self-management strategies for cancer and anxiety/depression.

Design: A semi-structured qualitative research design with theoretical thematic analysis.

Main Outcome Measures: Multimorbid illness representations, coping behaviours, and self-management strategies.

Results: In interviews with 21 participants multimorbid representations varied, three participants viewed cancer and anxiety/depression as unrelated, five participants were uncertain about the relationship between cancer and anxiety/depression, and the majority of participants perceived cancer and anxiety/depression as related. This third group of participants often described relationships as causal, with representations having both positive and negative influences on coping behaviours and self-management strategies. Representations were shown to change over the course of the cancer experience, with fear of cancer recurrence and the influence of participants’ most challenging illness also discussed.

Conclusions: People hold multimorbid illness representations that can influence self-management. An awareness of these representations by researchers, health professionals, and patients is important for the creation of future interventions that aim to improve and maintain patient wellbeing.     

Cognitive and affective predictors of boredom proneness

Boredom proneness has been linked to various forms of cognitive and affective dysregulation including poor self-control and mind-wandering (MW), as well as depression and aggression. As such, understanding boredom and the associated cognitive and affective components of the experience, represents an important first step in combatting the consequences of boredom for psychological well-being. We surveyed 1928 undergraduate students on measures of boredom proneness, self-control, MW, depression and aggression to investigate how these constructs were related. Hierarchical regression analysis indicated that self-control operated as a strong negative predictor of boredom proneness. Finally, when controlling for age and self-control, we observed large decreases in the magnitudes of the relationships between boredom proneness and our other measures of interest. Together, these results imply a strong relationship between boredom proneness and cognitive and affective dysregulation, and show that individual levels of self-control can account for the lion’s share of variance in the relationships between boredom, cognition, and affect.     

母亲抑郁对青少年抑郁的影响:亲子关系的中介作用与青少年消极情绪性的调节作用

对1708名八年级青少年（平均年龄14.30±0.48岁,男生852名）及其母亲（平均年龄39.17±2.47岁）的抑郁症状、母子关系和青少年消极情绪性进行测量,考察了母亲抑郁对青少年抑郁的影响机制。结果发现：（1）母亲抑郁能够正向预测青少年的抑郁;（2）母子关系在母亲抑郁与青少年抑郁之间起中介作用,母亲抑郁既能增加母子冲突的强度,也能降低母子亲合水平,进而导致青少年的抑郁;（3）青少年消极情绪性在母亲抑郁影响青少年抑郁的中介机制中起调节作用,仅在高消极情绪性的青少年中,母子冲突能够显著预测青少年的抑郁;但消极情绪性不能调节母子亲合对青少年抑郁的影响;（4）母亲抑郁影响青少年抑郁的有调节的中介模型不存在性别差异。     

Narcissistic configurations: Violence and its absence in treatment

'On narcissism: An introduction' constitutes a turning point in psychoanalysis. Although narcissism is a concept which has not been explicitly referred to by many important thinkers for decades, it could be said that there is no paper written in psychoanalysis since Freud that does not implicitly take into account the modifi cations in thinking that the work brought about. In this paper, the author contrasts two types of narcissistic confi gurations: in the fi rst, the intolerance of the other is dealt with by expulsion and violence; in the second, by withdrawal. The author contrasts patients who express manifest violent behaviour with patients for whom the violent behaviour is absent but who, nevertheless, present similar background histories, which might have led to a prediction of violence. They are also profoundly different in terms of what they provoke in the countertransference. In addition, this paper argues that the treatment of narcissistic personalities has allowed in recent years the understanding of a modality of depression. Following Green, the author argues that, instead of a fruitless debate that involves evolutionary issues around the concept of narcissism, it is necessary to distinguish the narcissistic aspect in any analytic relationship, to identify the narcissistic transference in different types of psychopathologies.