Multisensory integration in multiple reference frames in the posterior parietal cortex

Spatial information processing takes place in different brain regions that receive converging inputs from several sensory modalities. Because of our own movements—for example, changes in eye position, head rotations, and so forth—unimodal sensory representations move continuously relative to one another. It is generally assumed that for multisensory integration to be an orderly process, it should take place between stimuli at congruent spatial locations. In the monkey posterior parietal cortex, the ventral intraparietal (VIP) area is specialized for the analysis of movement information using visual, somatosensory, vestibular, and auditory signals. Focusing on the visual and tactile modalities, we found that in area VIP, like in the superior colliculus, multisensory signals interact at the single neuron level, suggesting that this area participates in multisensory integration. Curiously, VIP does not use a single, invariant coordinate system to encode locations within and across sensory modalities. Visual stimuli can be encoded with respect to the eye, the head, or halfway between the two reference frames, whereas tactile stimuli seem to be prevalently encoded relative to the body. Hence, while some multisensory neurons in VIP could encode spatially congruent tactile and visual stimuli independently of current posture, in other neurons this would not be the case. Future work will need to evaluate the implications of these observations for theories of optimal multisensory integration.Edited by: Marie-Hélène Giard and Mark Wallace     

Integrated memory for objects, places, and temporal order: evidence for episodic-like memory in mice

Human episodic memory refers to the recollection of an unique past experience in terms of what happened, and where and when it happened. Factoring out the issue of conscious recollection, episodic memory, even at the behavioral level, has been difficult to demonstrate in non-human mammals. Although, it was previously shown that rodents can associate what and when or what and where information given on unique trials, it proved to be difficult to demonstrate memory for what, where, and when simultaneously in mammals, without using extensive training procedures, which might induce semantic rather than episodic memory recall. Towards the goal of an animal model of human episodic memory we designed an three-trial object exploration task in which different versions of the novelty-preference paradigm were combined to subsume (a) object recognition memory, (b) the memory for locations in which objects were explored, and (c) the temporal order memory for object presented at distinct time points. We found that mice spent more time exploring two "old familiar" objects relative to two "recent familiar" objects, reflecting memory for what and when and concomitantly directed more exploration at a spatially displaced "old familiar" object relative to a stationary "old familiar" object, reflecting memory for what and where. These results suggest that during a single test trial the mice were able to (a) recognize previously explored objects, (b) remember the location in which particular objects were previously encountered, and (c) to discriminate the relative recency in which different objects were presented. According to the currently discussed behavioral criteria for episodic-like memory in animals, our results suggest that mice are capable to form such higher order memories.     

Neurocognitive mechanisms underlying the experience of flow

Recent theoretical and empirical work in cognitive science and neuroscience is brought into contact with the concept of the flow experience. After a brief exposition of brain function, the explicit-implicit distinction is applied to the effortless information processing that is so characteristic of the flow state. The explicit system is associated with the higher cognitive functions of the frontal lobe and medial temporal lobe structures and has evolved to increase cognitive flexibility. In contrast, the implicit system is associated with the skill-based knowledge supported primarily by the basal ganglia and has the advantage of being more efficient. From the analysis of this flexibility/efficiency trade-off emerges a thesis that identifies the flow state as a period during which a highly practiced skill that is represented in the implicit system's knowledge base is implemented without interference from the explicit system. It is proposed that a necessary prerequisite to the experience of flow is a state of transient hypofrontality that enables the temporary suppression of the analytical and meta-conscious capacities of the explicit system. Examining sensory-motor integration skills that seem to typify flow such as athletic performance, writing, and free-jazz improvisation, the new framework clarifies how this concept relates to creativity and opens new avenues of research.     

Multiple memory systems: the power of interactions

Two relatively simple theories of brain function will be used to demonstrate the explanatory power of multiple memory systems in your brain interacting cooperatively or competitively to directly or indirectly influence cognition and behaviour. The view put forth in this mini-review is that interactions between memory systems produce normal and abnormal manifestations of behaviour, and by logical extension, an understanding of these complex interactions holds the key to understanding debilitating brain and psychiatric disorders.     

Bimanual coordination in chronic schizophrenia

Anomalies of movement are observed both clinically and experimentally in schizophrenia. While the basal ganglia have been implicated in its pathogenesis, the nature of such involvement is equivocal. The basal ganglia may be involved in bimanual coordination through their input to the supplementary motor area (SMA). While a neglected area of study in schizophrenia, a bimanual movement task may provide a means of assessing the functional integrity of the motor circuit. Twelve patients with chronic schizophrenia and 12 matched control participants performed a bimanual movement task on a set of vertically mounted cranks at different speeds (1 and 2 Hz) and phase relationships. Participants performed in-phase movements (hands separated by 0 degrees ) and out-of-phase movements (hands separated by 180 degrees ) at both speeds with an external cue on or off. All participants performed the in-phase movements well, irrespective of speed or cueing conditions. Patients with schizophrenia were unable to perform the out-of-phase movements, particularly at the faster speed, reverting instead to the in-phase movement. There was no effect of external cueing on any of the movement conditions. These results suggest a specific problem of bimanual coordination indicative of SMA dysfunction per se and/or faulty callosal integration. A disturbance in the ability to switch attention during the out-of-phase task may also be involved.     

Explaining modulation of reasoning by belief

Although deductive reasoning is a closed system, one's beliefs about the world can influence validity judgements. To understand the associated functional neuroanatomy of this belief-bias we studied 14 volunteers using event-related fMRI, as they performed reasoning tasks under neutral, facilitatory and inhibitory belief conditions. We found evidence for the engagement of a left temporal lobe system during belief-based reasoning and a bilateral parietal lobe system during belief-neutral reasoning. Activation of right lateral prefrontal cortex was evident when subjects inhibited a prepotent response associated with belief-bias and correctly completed a logical task, a finding consistent with its putative role in cognitive monitoring. By contrast, when logical reasoning was overcome by belief-bias, there was engagement of ventral medial prefrontal cortex, a region implicated in affective processing. This latter involvement suggests that belief-bias effects in reasoning may be mediated through an influence of emotional processes on reasoning.     

The awareness of thirst: proposed neural correlates

The neural and endocrine bases of the generation of thirst are reviewed. Based on this review, a hierarchical system of neural structures that regulate water conservation and acquisition is proposed. The system includes primary sensory-receptive areas; secondary sensory structures (circumventricular organs), which detect levels of hormones, including angiotensin II and vasopressin, which are involved in generating thirst; preoptic and hypothalamic structures; and an area within the ventrolateral quadrant of the periaqueductal gray matter. Hodological and other data are used to determine the hierarchical organization of the system. Based on studies of the effects of lesions to various structures within the hierarchy of the system, it is proposed that the awareness of thirst in rodents is either entirely or predominantly due to neuronal activities in a subsection of the ventrolateral periaqueductal gray matter. It is also hypothesized that the awareness of thirst in primates is due to neuronal activities in both the ventrolateral periaqueductal gray and in a region within the medial prefrontal and anterior cingulate cortex.     

EFFECT OF ACADEMIC DEGREE AND DISCIPLINE ON RELIGIOUS BELIEFS AND EVOLUTION ACCEPTANCE: SURVEY AT A CHILEAN UNIVERSITY

Affiliation with a scientific area or degree program could affect one´s religious beliefs and acceptance of evolution; however, this issue has been poorly studied. Moreover, little information is available regarding Chilean university scientists’ views on religion and evolution. This study aims to provide the first documentation of the opinion of scientists at a Chilean University with regard to religion and evolution. This was done by conducting a personal survey of first and last year undergraduate students, graduate students, and faculty. We found that nonreligiosity, as well as acceptance of Darwinian evolution, increased with possession of an advanced degree and this correlation was stronger for individuals who study biology and physics in comparison to those who study chemistry. Although less than 30 percent of undergraduate students are atheists/agnostics, more than 70 percent of faculty members are atheist or agnostic. However, most of the surveyed scientists did not see a conflict between science and religion.     

Line-orientation generalization following signalled-reinforcer training

Three naive and three nonnaive pigeons key pecked for food on a multiple variable-interval 1-minute variable-interval 1-minute schedule with a black zero-degree vertical line on a white surround associated with one component and a black line shifted 30 degrees to the right (+30 degree) associated with the other component. Subsequently, a signalled-reinforcer procedure was introduced in the +30 degree component, i.e., whenever the reinforcer was available for the next response, the key changed to blank white. Following this training, the original unsignalled-reinforcer condition was re-instated. Line orientation generalization tests were given at the end of signalled-reinforcer training and after the second unsignalled-reinforcer condition. The signalled-reinforcer procedure reduced response rate in the +30-degree component in all subjects but facilitated responding during the zero-degree component (behavioral contrast) for two of the naive subjects only. However, average generalization gradients following signalled-reinforcer training indicated peak shift in two subjects and area shift in all five subjects that completed the experiment. There was no apparent relation between contrast and peak shift or degree of area shift. The data were interpreted as supporting the notion that the signalled-reinforcer procedure segments a variable-interval schedule into extinction and fixed ratio 1 segments.     

镜像等效或守恒及其打破：从行为到认知神经机制的研究证据

镜像等效或守恒是动物与人类个体对两侧对称自然物体的一种进化自适应加工。但是, 这种知觉特性会妨碍包含镜像字符的文字阅读学习。阅读者有必要学会利用镜像泛化抑制的“去学习”机制, 打破镜像等效或守恒, 以获得识别镜像字符的能力。这一过程中, 左侧梭状回皮层通过与早期视觉皮层、顶叶皮层和口语脑网络的交互作用, 逐渐发展出一个可以识别镜像字符的视觉词形区(visual word form area, VWFA)。今后的研究需要关注两半球及其连合纤维在镜像等效或守恒加工中的作用、镜像泛化与抑制的详尽加工机制及其对镜像书写的影响、正常汉语儿童的汉字镜像泛化加工等问题。